Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
256Glucoseembryo developmentrelateembryo developmentGO:0009790Homo sapiensGlucose uptakes on day 4 were significantly higher by embryos that went on to form blastocysts than by embryos that failed to develop to the blastocyst stage.11730746
257Glucoseembryo developmentrelateembryo developmentGO:0009790Homo sapiensNon-invasive microanalytical methods have been devised to study the energy metabolism of single human preimplantation embryos. Pyruvate, which is added routinely to all media used to culture human embryos, is consumed throughout the preimplantation period, with glucose assuming an increasing role at embryo compaction and blastocyst formation. 8517855
258Glutamateembryo developmentrelateembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
259Glutamateembryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260
260Glutamateembryo developmentaffectembryo developmentGO:0009790Mus musculusGlutamate appeared to be the key amino acids sought by embryos and embryos grown in amino-acid-containing media appeared morphologically normal and their volume increased compared with embryos cultured in the absence of amino acids.7799310
261Glutamateembryo developmentaffectembryo developmentGO:0009790Mus musculusglutamic acid can act as a signaling molecule in preimplantation embryos, exerting its effects through the activation of cell membrane receptors.35746896
262Glutamineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
263Glycerateembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
264Glycerol 3-phosphateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
265Glycerophosphorylcholineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
266Glycerophosphorylcholineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
267Glycine?embryo developmentaffectembryo developmentGO:0009790Mus musculusGlycine protects preimplantation mouse conceptuses from a detrimental effect on development of the inorganic ions in oviductal fluid2313249
268Glycine?embryo developmentaffectembryo developmentGO:0009790Mus musculusRegulation of intracellular glycine as an organic osmolyte in early preimplantation mouse embryos15672418
269Glycine?embryo developmentaffectblastocyst developmentGO:0001824Mus musculusThe presence of 1 mM glycine in vitrification solutions protects oocyte mitochondrial homeostasis and improves blastocyst development23248076
270Glycine?embryo developmentnotembryo developmentGO:0009790Mus musculusSupplement of 50 29379082

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.