Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
241Fumarateembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
242gamma-Aminobutyric Acidembryo developmentaffectembryo developmentGO:0009790Mus musculusgamma-Aminobutyric Acid affects embryo development32048404
243gamma-Aminobutyric Acidembryo developmentaffectembryo developmentGO:0009790Mus musculus[gamma-Aminobutyric Acid affects embryo development] which results in decreased embryo implantation32048404
244gamma-Aminobutyric Acidembryo developmentdecreaseblastocyst developmentGO:0001824Mus musculusgamma-Aminobutyric Acid results in decreased blastocyst development32048404
245GDPembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
246Genisteinembryo developmentaffectblastocyst developmentGO:0001824Mus musculusGenistein affects blastocyst development22553218
247Genisteinembryo developmentaffectembryonic cleavageGO:0040016Mus musculusGenistein affects embryonic cleavage22553218
248Ginsenoside Rg1embryo developmentaffectinner cell mass cell proliferationGO:0001833Mus musculusGinsenoside Rg1 results in decreased inner cell mass cell proliferation.28371286
249Ginsenoside Rg1embryo developmentincreasenegative regulation of embryonic developmentGO:0045992Mus musculusGinsenoside Rg1 results in increased negative regulation of embryonic development28371286
250Gluconateembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
251Glucoseembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
252Glucoseembryo developmentdecreaseembryo developmentGO:0009790Mus musculusPhysiological concentrations of glucose inhibit the development of the 2-cell embryo in vitro11139555, 2760894, 1786289, 1518005, 8375542, 8868247, 8862777
253Glucoseembryo developmentaffectembryo developmentGO:0009790Mus musculusGlucose is an essential component of the culture medium for development to the blastocyst stage1769345, 1518005
254Glucoseembryo developmentaffectblastocyst developmentGO:0001824Homo sapiensOmitting glucose at early cleavage stages helps to overcome the block to development at the four-eight-cell stage, and significantly increases the number of trophectoderm cells of the resulting blastocysts for the culture media for human embryos, 8283458
255Glucoseembryo developmentdecreaseembryo developmentGO:0009790Homo sapiensPhysiological concentrations of glucose inhibit the development of the 2-cell embryo in vitro11139555, 8283458, 7890083, 7890083

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.