Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
211Erlotinib Hydrochlorideembryo developmentdecreaseclearance of cells from fusion plateGO:0060884Homo sapiensErlotinib Hydrochloride results in decreased clearance of cells from fusion plate28898253
212Estradiolembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
213Ethanolembryo developmentaffectembryo developmentGO:0009790Mus musculusEthanol affects embryo development19091803
214Ethanolembryo developmentdecreaseDNA methylation involved in embryo developmentGO:0043045Mus musculusEthanol results in decreased DNA methylation involved in embryo development23544149
215Ethanolembryo developmentdecreaseembryonic body morphogenesisGO:0010172Mus musculusEthanol results in decreased embryonic body morphogenesis26074427
216Ethanolembryo developmentdecreasesomite developmentGO:0061053Mus musculusEthanol results in decreased somite development26074427
217Ethanolembryo developmentaffectneural tube developmentGO:0021915Mus musculusEthanol affects neural tube development19091803|34492310
218Ethanolembryo developmentaffectembryo developmentGO:0009790Mus musculusEthanol-treated embryos had significantly lower scores for 12 scoring items of morphological features compared with the control group. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation
219Ethanolembryo developmentdecreaseembryonic body morphogenesisGO:0010172Homo sapiensEthanol results in decreased embryonic body morphogenesis.26074427
220Ethanolembryo developmentdecreaseanterior neuropore closureGO:0021506Homo sapiensEthanol results in decreased anterior neuropore closure.26074427
221Ethanolembryo developmentincreasesomite developmentGO:0061053Homo sapiensEthanol results in decreased somite development.26074427
222Ethanolamine phosphateembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
223FADembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
224Fatty acidembryo developmentaffectembryo developmentGO:0009790Homo sapiensPreimplantation human embryos actively take up individual fatty acids at different rates at different stages of development. The high unsaturated concentration at the later stages of development may be explained by preferential uptake of linoleic acid.16311299
225Fenvalerateembryo developmentaffectlabyrinthine layer blood vessel developmentGO:0060716Mus musculusFenvalerate affects labyrinthine layer blood vessel development28369636

Showing 211 to 225 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.