Chemicals with Transgenerational Effects on Disease or Function

Show
entries
No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
196Dorsomorphinembryo developmentincreasegrowth involved in heart morphogenesisGO:0003241Mus musculusDorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.18682835
197Dronabinolembryo developmentdecreasesyncytiotrophoblast cell differentiation involved in labyrinthine layer developmentGO:0060715Homo sapiensDronabinol results in decreased syncytiotrophoblast cell differentiation involved in labyrinthine layer development26070387
198Dronedaroneembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculusDronedarone results in decreased embryonic morphogenesis26385866
199dTMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
200dTTPembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
201Dynorphin B?embryo developmentincreasegrowth involved in heart morphogenesisGO:0003241Mus musculusDynorphin B induces cardiomyogenesis in P19 cells.15023550?
202Elvitegravirembryo developmentdecreaseembryonic morphogenesisGO:0048598Mus musculuselvitegravir results in decreased embryonic morphogenesis34515794
203Enniatin B1 (ENN B1)embryo developmentaffectembryo developmentGO:0009790Mus musculusEnniatin B1 (ENN B1) exerts cytotoxic effects on mouse blastocyst-stage embryos and induces intracellular oxidative stress and immunotoxicity in mouse fetuses. 30259633
204Enniatin B1 (ENN B1)embryo developmentaffectembryo developmentGO:0009790Mus musculusEnniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development.33106064
205Enniatinsembryo developmentdecreaseembryonic limb morphogenesisGO:0030326Mus musculusEntinostat results in decreased embryonic limb morphogenesis26251326
206Enniatinsembryo developmentdecreaseblastocyst growthGO:0001832Mus musculusEnniatins results in decreased blastocyst growth.30259633
207Enniatinsembryo developmentdecreaseinner cell mass cell proliferationGO:0001833Mus musculusEnniatins results in decreased inner cell mass cell proliferation.30259633
208Epinephrineembryo developmentdecreaseembryo developmentGO:0009790Mus musculus[Epinephrine affects embryo implantation] which results in decreased embryo development31520687
209Epoxiconazoleembryo developmentdecreaseembryo developmentGO:0009790Mus musculusEpoxiconazole has been shown to be weakly embryotoxic in the mouse embryonic stem cell test (mEST)23861077
210Epoxiconazoleembryo developmentdecreaseembryo developmentGO:0009790Homo sapiensEpoxiconazole showed cytotoxicity from 50 ?M and upward in human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB)32700165

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.