Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1662'-Deoxyadenosineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
167Deoxycorticosteroneembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
168Deoxyriboseembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
169Dexamethasoneembryo developmentdecreaseembryo developmentGO:0009790Homo sapiensUsing human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB) as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds. The results showed that the compounds differentially repressed cell growth, compromised morphology, and triggered apoptosis in the EBs.34742744
170Diallyl trisulfideembryo developmentincreasenegative regulation of heterotypic cell-cell adhesionGO:0034115Homo sapiensdiallyl trisulfide results in increased negative regulation of heterotypic cell-cell adhesion28574600
171Dibutyl Phthalateembryo developmentdecreaseembryo developmentGO:0009790Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased embryo development33711355
172Dibutyl Phthalateembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of Dibutyl Phthalate] which results in decreased embryonic hindlimb morphogenesis24503621
173Dietary fatsembryo developmentaffectembryo developmentGO:0009790Mus musculusThe first is oocyte meiotic aneuploidy that then leads to early embryonic loss. The second is an abnormal process distinct from meiotic aneuploidy that also leads to early embryonic loss. The third is fetal growth retardation and brain developmental abnormalities,23152876
174Dietary fatsembryo developmentdecreaseembryo developmentGO:0009790Mus musculusThe first is oocyte meiotic aneuploidy that then leads to early embryonic loss. The second is an abnormal process distinct from meiotic aneuploidy that also leads to early embryonic loss. The third is fetal growth retardation and brain developmental abnormalities,23152876
175Diethyl phthalateembryo developmentdecreaseembryo developmentGO:0009790Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased embryo development33711355
176Diethyl phthalateembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of diethyl phthalate] which results in decreased embryonic hindlimb morphogenesis24503621
177Diethylhexyl phthalateembryo developmentdecreaseneural tube closureGO:0001843Mus musculusDiethylhexyl Phthalate results in decreased neural tube closure28123099
178Diethylhexyl phthalateembryo developmentdecreaseembryonic cleavageGO:0040016Mus musculusDiethylhexyl Phthalate results in decreased embryonic cleavage28286118
179Diethylhexyl phthalateembryo developmentdecreaseembryo developmentGO:0009790Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased embryo development33711355
180Diethylhexyl phthalateembryo developmentdecreaseembryonic hindlimb morphogenesisGO:0035116Homo sapiens[Phthalic Acids results in increased abundance of Diethylhexyl Phthalate] which results in decreased embryonic hindlimb morphogenesis24503621

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.