Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
151Creatineembryo developmentaffectembryo implantationGO:0007566Mus musculusPreimplantation embryos need the arginine metabolite, creatine, and they express creatine kinase6402403, 12801981
152Creatinineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
153Cycloheximideembryo developmentaffecttrophectodermal cell differentiationGO:0001829Mus musculusTo test whether translation is required for the amino acid effect on trophectoderm differentiation, we inhibited translation in a general way, by treating blastocysts with cycloheximide during the 8-h exposure to amino acids at 120 h posthCG. This treatment inhibited subse quent outgrowth, demonstrating that protein translation is required during this period for the later onset of motility.11784055
154Cycloleucineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
155Cyclophosphamideembryo developmentdecreaseembryo developmentGO:0009790Mus musculusCyclophosphamide results in decreased embryo development31557371
156Cyclosporineembryo developmentincreaseembryo developmentGO:0009790Mus musculusAn inhibitor of the protein phosphatase 2B, cyclosporin, have the most striking pro-cardiomyogenic effects in mouse ES cells. 17979183?
157Cystathionineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
158Cysteineembryo developmentrelatedembryo developmentGO:0009790Mus musculusMetabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC36167681
159L-Cystineembryo developmentaffectembryo developmentGO:0009790Mus musculusArginine, cystine, histidine, leucine and threonine were needed for outgrowth of the mouse blastocyst in vitro.Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
160Cytidineembryo developmentrelatedembryo developmentGO:0009790Mus musculusSignificantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography34428399
161Cytochalasin Bembryo developmentincreaseembryo developmentGO:0009790Mus musculusSix-hour treatment with 10 mmol/L strontium chloride (SrCl2) in Ca2+ alone or in combination with cytochalasin B can well activate nuclear transfer embryos in mice.23297500
162dAMPembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
163D-cysteineembryo developmentnotembryo developmentGO:0009790Mus musculus L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. 25715791
164DDTembryo developmentincreasechanges to DNA methylation involved in embryo developmentGO:1901538Homo sapiens[[[Environmental Pollutants results in increased abundance of DDT] which affects changes to DNA methylation involved in embryo development] which affects genomic imprinting] which results in increased methylation of IGF2 gene30005188
165Dehydroepiandrosteroneembryo developmentdecreaseblastocyst growthGO:0001832Mus musculusDuring maturation of cumulus-oocyte-complexes (COCs) with glucose, the presence of PPP inhibitor, DHEA or glycolysis inhibitor, iodoacetate significantly decreased blastocyst rates, intraoocyte glutathione and ATP. 26857840

Showing 151 to 165 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.