Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1246
Diethylhexyl phthalate
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
[Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in decreased spermatogenesis
18570050
1247
Diisobutyl phthalate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis
30802670
1248
Diisobutyl phthalate
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development
30802670
1249
Diisobutyl phthalate
male gamete generation
decrease
sperm capacitation
GO:0048240
Mus musculus
An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.
33711355
1250
Diisobutyl phthalate
male gamete generation
increase
sperm capacitation
GO:0048240
Mus musculus
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation
33711355
1251
Diisodecyl phthalate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis
30802670
1252
Diisodecyl phthalate
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development
30802670
1253
Diisodecyl phthalate
male gamete generation
decrease
sperm capacitation
GO:0048240
Mus musculus
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation
33711355
1254
Diisodecyl phthalate
male gamete generation
decrease
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Mus musculus
An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.
33711355
1255
Dimethoate
male gamete generation
decrease
spermatid development
GO:0007286
Mus musculus
Dimethoate results in decreased spermatid development
26482405
1256
Dimethyl phosphate
male gamete generation
decrease
spermatid development
GO:0007286
Homo sapiens
Dimethyl phosphate results in decreased spermatid development
20850521
1257
Dioxins
male gamete generation
decrease
spermatogenesis
GO:0007283
Homo sapiens
Dioxins results in decreased spermatogenesis
21262597
1258
Docosahexaenoic acid
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Docosahexaenoic acid was effective at stimulating ROS generation by human spermatozoa.
16895947
1259
Doxorubicin
male gamete generation
affect
male germ-line mutations
N/A
Mus musculus
Low levels of chromosomal mutations in germ cells derived from doxorubicin-treated stem spermatogonia in the mouse
2295076
1260
Emodin
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Emodin results in decreased spermatogenesis
21319176
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
