Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1231Diethyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis30802670
1232Diethyl phthalatemale gamete generationdecreasespermatid developmentGO:0007286Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development30802670
1233Diethyl phthalatemale gamete generationdecreasesperm capacitationGO:0048240Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1234Diethyl phthalatemale gamete generationdecreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1235Diethyl phthalatemale gamete generationincreasesperm capacitationGO:0048240Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation33711355
1236Diethyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[diethyl phthalate results in increased abundance of monoethyl phthalate] which results in decreased spermatogenesis18570050
1237Diethylhexyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis29029336
1238Diethylhexyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis30802670
1239Diethylhexyl phthalatemale gamete generationdecreasespermatid developmentGO:0007286Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development30802670
1240Diethylhexyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusicariin inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis]31175881
1241Diethylhexyl phthalatemale gamete generationaffectacrosome assemblyGO:0001675Mus musculusDiethylhexyl Phthalate affects acrosome assembly32619501
1242Diethylhexyl phthalatemale gamete generationaffectspermatogenesisGO:0007283Mus musculusDiethylhexyl Phthalate results in decreased spermatogenesis32619501
1243Diethylhexyl phthalatemale gamete generationincreasesperm capacitationGO:0048240Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation33711355
1244Diethylhexyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusGallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis]35196152
1245Diethylhexyl phthalatemale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased spermatogenesis18570050

Showing 1231 to 1245 of 1481 entries

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.