Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
1216Dextran Sulfatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusSulfasalazine inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis]28421826
1217Diethylhexyl phthalatemale gamete generationdecreasesperm capacitationGO:0048240Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1218Diethylhexyl phthalatemale gamete generationdecreasepositive regulation of flagellated sperm motility involved in capacitationGO:0060474Mus musculusAn environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development.33711355
1219Dibutyl Phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis29029336
1220Dibutyl Phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis30802670
1221Dibutyl Phthalatemale gamete generationdecreasespermatid developmentGO:0007286Mus musculus[Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development30802670
1222Dibutyl Phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusDibutyl Phthalate results in decreased spermatogenesis33331133
1223Dibutyl Phthalatemale gamete generationdecreasespermatogenesisGO:0007283Mus musculusginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased spermatogenesis]33331133
1224Dibutyl Phthalatemale gamete generationincreasesperm capacitationGO:0048240Mus musculus[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation33711355
1225Dibutyl Phthalatemale gamete generationaffectspermatid developmentGO:0007286Mus musculusDibutyl Phthalate affects spermatid development34280466
1226Dibutyl Phthalatemale gamete generationdecreasespermatogenesisGO:0007283Homo sapiens[Dibutyl Phthalate results in increased abundance of monobutyl phthalate] which results in decreased spermatogenesis17003688
1227Dichlorodiphenyl Dichloroethylenemale gamete generationaffectmale meiosis chromosome separationGO:0051308Homo sapiensDichlorodiphenyl Dichloroethylene affects male meiosis chromosome separation26535963
1228Dichlorodiphenyl Dichloroethylenemale gamete generationaffectspermatogenesisGO:0007283Homo sapiensDichlorodiphenyl Dichloroethylene affects spermatogenesis15687046
1229Dietary arachidonic acid (AA)male gamete generationaffectspermatogenesisGO:0007283Mus musculusThe effects of dietary AA and DHA on the fertility and spermatogenesis of the D6D-null males. Supplementing 0.2% DHA alone was able to fully restore male fertility, spermiogenesis, sperm morphology, and sperm count in -/- males. This restoration occurred despite very low AA and near depletion of DPAn6, the major HUFA present in +/+ males.19690334
1230Dietary docosahexaenoic acid (DHA)male gamete generationaffectspermatogenesisGO:0007283Mus musculusSupplementing 0.2% DHA alone was able to fully restore male fertility, spermiogenesis, sperm morphology, and sperm count in -/- males.19690334

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.