Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
901Oxamate?female gamete generationdecreaseoocyte maturationGO:0001556Mus musculusPercentages of MII oocytes decreased significantly with increasing concentrations of oxamte.26857840
902Taxolfemale gamete generationdecreasepreantral ovarian follicle growthGO:0001546Mus musculusPaclitaxel (Taxol) results in decreased preantral ovarian follicle growth35584731
903Palmitic acidfemale gamete generationrelateoocyte developmentGO:0048599Homo sapiensMetabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence23886995
904Palmitoleic acid (C16:1)female gamete generationnotoocyte developmentGO:0048599Homo sapiensMetabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence23886995
905Pantothenolfemale gamete generationrelatedoogenesisGO:0048477Mus musculusSignificantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
906Patulinfemale gamete generationdecreaseoocyte maturationGO:0001556Mus musculusPatulin results in decreased oocyte maturation34718031
907PD 0166285female gamete generationdecreasemeiotic cell cycle process involved in oocyte maturationGO:1903537Mus musculusPD 0166285 inhibits the reaction [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation]35504548
908Pentachlorophenolfemale gamete generationincreaseovulation from ovarian follicleGO:0001542Homo sapiensPentachlorophenol inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle]19368227
909Pentadecanoic acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
910perfluorodecanoic acidfemale gamete generationincreasenegative regulation of meiotic cell cycle process involved in oocyte maturationGO:1904145Mus musculusperfluorodecanoic acid results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation34358620
911Petroselinic acidfemale gamete generationNotoogenesisGO:0048477Mus musculusNot significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))33068521
912Phosphocholinefemale gamete generationrelateoogenesisGO:0009790Homo sapiensOocytes which failed to cleave as an embryo had lower follicular fluid levels of phosphocholine than embryos that implanted. 22365382
913procyanidin B2female gamete generationaffectoogenesisGO:0048477Mus musculusAntioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension35971139, 35399525
914Progesteronefemale gamete generationdecreaseinitiation of primordial ovarian follicle growthGO:0001544Mus musculusProgesterone inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo.17446182
915L-Prolinefemale gamete generationrelateoogenesisGO:0009790Homo sapiensPatients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of proline.22365382

For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.

Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.