Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
871
Mycotoxin citrinin
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
The mycotoxin citrinin (CTN), a natural contaminant in foodstuffs and animal feeds, exerts cytotoxic and genotoxic effects on various mammalian cells and embryos. A previous investigation by our group revealed potentially hazardous effects of CTN on mouse oocyte maturation and pre- and post-implantation embryo development via the induction of apoptosis.
29186930
872
Myristic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
873
Myristic acid
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
874
n-3 PUFA
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
exposure of the oocyte during maturation in the ovary to an environment high in n-3 PUFA resulted in altered mitochondrial distribution and calcium levels and increased production of reactive oxygen species.
18073322
875
n-3 PUFA
female gamete generation
relate
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
876
n-6 PUFA
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
877
N6-(R-phenylisopropyl)-adenosine (R-PIA)
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
A dose-response experiment was conducted to assess
the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. A high-inhibition group, composed of
adenosine, 2-Cl-Ado, and R-PIA, in which a low percentage of oocytes resumed maturation (0
10331459
878
N6-cyclopentyladenosine (CPA)
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
A dose-response experiment was conducted to assess
the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. An intermediate-inhibition group, composed of APNEA and CPA, in which a modest inhibitory action was observed (30
10331459
879
N-Acetyl-L-Cysteine
female gamete generation
increase
oogenesis
GO:0048477
Mus musculus
The addition of NAC after vitrification improves the quality of vitrified mature murine oocytes while its addition prior to vitrification is advised against.
30654800
880
N-Acetylethylenediamine
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
881
N-Acetylglutamic acid
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
882
N-acetyl-L-cysteine?
female gamete generation
affect
oogenesis
GO:0009790
Mus musculus
the frequency of spindle defects decreased in NAC-treated oocytes compared to those without NAC treatment.
30978175
883
N-Acetyl-L-methionine
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
884
N-Acetylneuraminic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
885
NAD+
female gamete generation
affect
Zygotic H3K27ac
N/A
Mus musculus
NAD+-mediated erasure of zygotic H3K27ac is required for the exit of minor ZGA. NAD+ could cooperate with Sirt1 to remove zyH3K27ac.
36167681
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
