Chemicals with Transgenerational Effects on Disease or Function
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entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
856
Lysophosphatidic acid
female gamete generation
increase
oogenesis
GO:0009790
Homo sapiens
Lysophosphatidic Acid is abundant in seminal plasma and follicular fluid. It enhances follicle stimulation.
35903269?
857
Lysophosphatidylcholine
female gamete generation
relate
follicle development
N/A
Homo sapiens
Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development
35906399
858
Malathion
female gamete generation
increase
oocyte maturation
GO:0001556
Homo sapiens
Malathion inhibits the reaction [CGA protein results in increased oocyte maturation]
30266436
859
Melatonin
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
860
Melatonin
female gamete generation
increase
negative regulation of oocyte maturation
GO:1900194
Mus musculus
Melatonin inhibits the reaction [Dimethylformamide results in increased negative regulation of oocyte maturation]
35238128
861
Melatonin
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
melatonin comprehensively protected oocyte against the defects induced by nivalenol exposure and improved the oocyte quality during mouse oocyte maturation.
Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage?
862
Melatonin
female gamete generation
increase
oocyte maturation
GO:0001556
Homo sapiens
Melatonin promotes human oocyte maturation.
31361919
863
Methylmercaptopurine riboside
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
MMPR stimulated a significant increase
in oocyte maturation.
10331459
864
MG-132
female gamete generation
affect
oocyte maturation
GO:0001556
Mus musculus
MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes
12437781
865
MG-132
female gamete generation
affect
oocyte aneuploidy
N/A
Mus musculus
The transient inhibition of proteasome-mediated proteolysis during oocyte maturation (OM) by MG-132 resulted in dose-response delays during OM and elevated levels of aneuploid MII oocytes.
12437781
866
Mono(2-ethyl-6-hydroxyhexyl) phthalate
female gamete generation
decrease
oocyte maturation
GO:0001556
Homo sapiens
mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased oocyte maturation
26545148
867
Mono(2-ethyl-6-oxohexyl)phthalate
female gamete generation
decrease
oocyte maturation
GO:0001556
Homo sapiens
mono(2-ethyl-5-oxohexyl)phthalate results in decreased oocyte maturation
26545148
868
Mono-(2-ethylhexyl)phthalate
female gamete generation
decrease
oocyte maturation
GO:0001556
Homo sapiens
mono-(2-ethylhexyl)phthalate results in decreased oocyte maturation
26545148
869
Mycophenolic acid
female gamete generation
decrease
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Homo sapiens
in vitro in the cumulus-enclosed oocytes treated with IMPDH inhibitor mycophenolic acid (MPA). Inhibition of IMPDH activity in oocytes and preimplantation embryos compromises oocyte meiotic.
34124077
870
Mycotoxin
female gamete generation
increase
DNA methylation involved in gamete generation
GO:0043046
Mus musculus
The fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.?Mycotoxin-contaminated maize (deoxynivalenol (DON) at 3,875
24288346, 24810297
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