Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
706
Cholesterol
female gamete generation
increase
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the Cholest-5-ene-3
7700384, 11988327
707
Cholesterol
female gamete generation
affect
meiotic cell cycle process involved in oocyte maturation
GO:1903537
Mus musculus
Cholesterol can activate WT mouse eggs to escape from MII arrest.
25368174
708
Cholesterol
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
709
Cholic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
710
Choline
female gamete generation
relate
oogenesis
GO:0009790
Homo sapiens
Oocytes which failed to cleave as an embryo had lower follicular fluid levels of choline than embryos that implanted.
22365382
711
Chorionic Gonadotropin
female gamete generation
increase
positive regulation of ovulation
GO:0060279
Homo sapiens
Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased positive regulation of ovulation]
26923738
712
Chorionic Gonadotropin
female gamete generation
increase
positive regulation of ovulation
GO:0060279
Homo sapiens
Chorionic Gonadotropin results in increased positive regulation of ovulation
26923738
713
cis-11-Eicosanoic acid (C20:1)
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
714
Aconitic acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
715
cis-Eicosadienoic acid (C20:2)
female gamete generation
not
oocyte development
GO:0048599
Homo sapiens
Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence
23886995
716
Citric acid
female gamete generation
related
oogenesis
GO:0048477
Mus musculus
Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
717
Cortisol
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
718
Cortisone
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
719
Cyclic AMP
female gamete generation
Not
oogenesis
GO:0048477
Mus musculus
Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))
33068521
720
Cyclophosphamide
female gamete generation
decrease
follicle loss
N/A
Mus musculus
There was a gradual process of follicle loss and low estradiol in Busulfan/cyclophosphamide (Bu/Cy) -treated mice; this is a profile similar to what is found in women with premature ovarian failure (POF).
23549849, 27806317
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