Chemicals with Transgenerational Effects on Disease or Function

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No. Chemical Name GO Biological Process Effect Specific BP GO Species Description PMID
541threonineembryo developmentrelatedblastocyst growthGO:0001832Mus musculusArginine, cystine, histidine, leucine and threonine were needed for outgrowth of the mouse blastocyst in vitro.Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
542Retinoic acidembryo developmentaffectregulation of gastrulationGO:0010470Mus musculusTretinoin affects regulation of gastrulation28184906
543Retinoic acidembryo developmentaffectendodermal cell differentiationGO:0035987Homo sapiensTretinoin affects endodermal cell differentiation31600526
544Retinoic acidembryo developmentincreaseneural plate developmentGO:0001840Homo sapiens[[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] affects cell differentiation] which results in increased neural plate development31711903
545Triacylglycerolembryo developmentrelateembryo developmentGO:0009790Mus musculusTriacylglycerol (TAG) were distributed around the brown adipose tissue and in the liver at embryo day?17.5.19685253
546Tributyltinembryo developmentaffectembryonic placenta developmentGO:0001892Mus musculustributyltin affects embryonic placenta development33720505
547Trichostatin Aembryo developmentincreaseembryo developmentGO:0009790Mus musculusIncomplete and inaccurate genomic reprogramming of somatic cell nuclear transfer (SCNT)-generated embryos was improved by trichostatin A treatment.20505166
548Trichostatin Aembryo developmentincreaseblastocyst developmentGO:0001824Mus musculusTrichostatin A treatments resulted in a blastocyst development rate significantly higher than the obtained in the corresponding control group.20698782
549Trichostatin Aembryo developmentdecreasepositive regulation of convergent extension involved in gastrulationGO:1904105Mus musculusTrichostatin A results in decreased positive regulation of convergent extension involved in gastrulation27693483
550Trimethylamine N-oxideembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
551Trimethyllysineembryo developmentrelatedembryo developmentGO:0009790Mus musculusHigher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography34650276
552Tri-o-cresyl phosphateembryo developmentdecreaselabyrinthine layer developmentGO:0060711Mus musculustri-o-cresyl phosphate results in decreased labyrinthine layer development31566301
553Tri-o-cresyl phosphateembryo developmentdecreasespongiotrophoblast layer developmentGO:0060712Mus musculustri-o-cresyl phosphate results in decreased spongiotrophoblast layer development31566301
554Tryptophaneembryo developmentrelatedembryo developmentGO:0009790Mus musculusOmission of tryptophane from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely.Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343.
555TSP (sodium 3-(trimethyl-2,2,3,3)-1-propionic acid-d4)embryo developmentrelateembryo developmentGO:0009790Homo sapiensThe IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization).18842260

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.