Chemicals with Transgenerational Effects on Disease or Function
Show
entries
No.
Chemical Name
GO Biological Process
Effect
Specific BP
GO
Species
Description
PMID
1471
Vitamin D
male gamete generation
increase
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Vitamin D enhances sperm vitality and the acrosome reaction and reduces the content of triglyceride in spermatozoa, which effectively increases their fertilization ability in the female reproductive tract.
30618415, 21270327, 27496946
1472
Vitamin D
male gamete generation
relate
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
Significant correlation between vitamin D levels and sperm parameters, with a particular emphasis on sperm motility, and partially suggest a relationship between higher serum testosterone and vitamin D levels.
36672602, 31561004, 31190482, 36014783, 27496946
1473
Vitamins
male gamete generation
affect
positive regulation of flagellated sperm motility involved in capacitation
GO:0060474
Homo sapiens
There was a significant correlation between using vitamins and improved spermatozoa quality; the sperm motility and viability were improved and DNA fragmentation was reduced after thawing by vitamins.?
1474
Zearalenone
male gamete generation
decrease
acrosome assembly
GO:0001675
Mus musculus
Zearalenone results in decreased acrosome assembly
31419471
1475
Zearalenone
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Zearalenone results in decreased spermatogenesis
31419471
1476
Zearalenone
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
Low dose (lower than no-observed effect level, NOEL) of ZEA impaired mouse spermatogenesis and decreased mouse semen quality.?
28837831
1477
Zinc
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis]
34508822
1478
Zinc Acetate
male gamete generation
decrease
spermatogenesis
GO:0007283
Mus musculus
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis]
34508822
1479
Metformin
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
metformin treatment of oocytes from aged mice can apparently improve in vitro maturation (IVM) rates.
36393869
1480
quercetin
female gamete generation
increase
oocyte maturation
GO:0001556
Mus musculus
Treating oocytes from aged mice with quercetin improves oocyte maturation.
33177495
For any questions on the database, please send E-mail to caoyuedi@sjtu.edu.cn.
