Proteins with Transgenerational Effects on Disease or Function

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No. Entry Entry Name Protein Names Gene Names Organism GO Biological Process Structure PDB ID for Docking Interaction Molecules
616P29121PCSK4_MOUSEProprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (KEX2-like endoprotease 3) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3)Pcsk4 Nec-3 Nec3Mus musculus (Mouse)Male gamete generationP29121Cyclophosphamide
617P28047WNT7B_MOUSEProtein Wnt-7bWnt7b Wnt-7bMus musculus (Mouse)embryo developmentP28047Cyclophosphamide
618Q80ZE4PAQR7_MOUSEMembrane progestin receptor alpha (mPR alpha) (Membrane progesterone P4 receptor alpha) (Membrane progesterone receptor alpha) (PPAR-gamma-induced liver protein) (Progesterone and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII)Paqr7 Mpra PglpMus musculus (Mouse)Female gamete generationQ80ZE4Cyclophosphamide
619Q96MU7YTDC1_HUMANYTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)YTHDC1 KIAA1966 YT521Homo sapiens (Human)Female gamete generation; Male gamete generation; embryo development6SZXCyclophosphamide
620A6ND01JUNO_HUMANSperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO)IZUMO1R FOLR4 JUNOHomo sapiens (Human)Fertilization5F4QCyclophosphamide
621P84244H33_MOUSEHistone H3.3H3-3a H3.3a H3f3a; H3-3b H3.3b H3f3bMus musculus (Mouse)Female gamete generation; Male gamete generation; Fertilization5XM1Cyclophosphamide
622P50990TCPQ_HUMANT-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)CCT8 C21orf112 CCTQ KIAA0002Homo sapiens (Human)Fertilization7NVL_P50990Cyclophosphamide
623P41439FOLR3_HUMANFolate receptor gamma (FR-gamma) (Folate receptor 3)FOLR3Homo sapiens (Human)FertilizationP41439Cyclophosphamide
624O88508DNM3A_MOUSEDNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA)Dnmt3aMus musculus (Mouse)Male gamete generation3SWCCyclophosphamide
625P56726SMO_MOUSESmoothened homolog (SMO)Smo SmohMus musculus (Mouse)Embryo development6O3CCyclophosphamide
626Q99832TCPH_HUMANT-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]CCT7 CCTH NIP7-1Homo sapiens (Human)Fertilization7NVLCyclophosphamide
627Q9JK91MLH1_MOUSEDNA mismatch repair protein Mlh1 (MutL protein homolog 1)Mlh1Mus musculus (Mouse)Female gamete generationQ9JK91Cyclophosphamide
628E9Q9F6CTSRD_MOUSECation channel sperm-associated auxiliary subunit delta (CatSper-delta) (CatSperdelta) (Transmembrane protein 146)Catsperd Tmem146Mus musculus (Mouse)Male gamete generation7EEBE9Q9F6Deferoxamine
629P0DP43CTSRE_MOUSECation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon) (C1orf101-like protein)Catspere Catspere1 Gm7068Mus musculus (Mouse)Male gamete generation7EEBP0DP43Deferoxamine
630P05132KAPCA_MOUSEcAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)Prkaca PkacaMus musculus (Mouse)Male gamete generation; Embryo development7V0GDeferoxamine

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Copyright © Haifeng Chen Lab, Shanghai Jiao Tong University.