Chemical_Name Biological process Effect_on_Biological process Biological process to be more specific GO ID Species_Evidence Description PMID Indolactam V embryo development affect ESC differentiation N/A Mus musculus the effects of (-) Indolactam V on a population of mouse ESCs (mESCs) that had been induced to form definitive endoderm (DE) "19287398, 19896224" Indolactam V embryo development affect ESC differentiation N/A Homo sapiens "High-content chemical screening identified a small molecule, (?)-indolactam V, that induces differentiation of a substantial number of Pdx1-expressing cells from human ESCs" "19287398, 19896224" 13-cis-retinoic acid embryo development decrease mesoderm formation GO:0001707 Homo sapiens Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid 30154523 1-Methyladenosine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 1-Methylhistidine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 1-Methylnicotinamide embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 "2,2',4,4'-tetrabromodiphenyl ether" embryo development increase DNA methylation involved in embryo development GO:0043045 Homo sapiens "[[Environmental Pollutants results in increased abundance of Halogenated Diphenyl Ethers] which results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which affects DNA methylation involved in embryo development" 32653021 "2,4-diaminobuturic acid" embryo development decrease embryo development GO:0009790 Mus musculus "2,4-diaminobuturic acid at a low concentration irreversibly damaged the trophoblast cells and prevented outgrowth, probably due to nonsaturation kinetics resulting in a high intracellular accumulation." 525368 "2,6DQT" embryo development increase blastocyst development GO:0001824 Mus musculus "In vitro fertilization (IVF) experiments using Swiss albino mice revealed that spermatozoa processed with 2,6DQT resulted in significantly lower blastocyst rate (P < 0.05) compared to control. (2,6DQT ((4-((2,6-Dichloroquinolin-3-yl)methyl)- 2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one)) " 33237520 2-Aminoadipate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 2-chloro-5-nitrobenzanilide embryo development decrease cell differentiation involved in embryonic placenta development GO:0060706 Homo sapiens 2-chloro-5-nitrobenzanilide results in decreased cell differentiation involved in embryonic placenta development 30810372 2'-Deoxyadenosine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 2'-Deoxyadenosine embryo development decrease embryo development GO:0009790 Mus musculus "If sperm were treated by both pentoxifylline and 2-deoxyadenosine before insemination of postovulatory mouse oocytes, two-cell embryo formation was found to be reduced even if both agents were eluted from the sperm before insemination. " 8062965 2'-Deoxycytidine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 2'-Deoxycytidine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 2-deoxy-glucose embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 2-deoxyinosine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 2-Deoxy-ribose-5-phosphate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 2-Hydroxyglutarate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 2-Hydroxyisocaproate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 "3,4-dihydropyrimido[4,5-d]pyrimidines" embryo development affect ESC differentiation N/A Mus musculus "A class of 3,4-dihydropyrimido[4,5-d]pyrimidines was characterized that maintain the undifferentiated phenotype of mES cells in a dose-dependent manner" 17088537 3-Methylhistidine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 3-Phenyllactate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 3-Phenyllactic acid embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 SB431542 embryo development increase neural plate development GO:0001840 Homo sapiens "[[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] affects cell differentiation] which results in increased neural plate development" 31711903 4-Hydroxybenzoate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 4-Hydroxybenzoic acid embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 5-aza-2∩-deoxycytidine (5-aza-dC) embryo development increase embryo development GO:0009790 Homo sapiens the cardiomyocyte differentiation of human ES cells is enhanced by treatment of 5-aza-2∩-deoxycytidine (5-aza-dC) 17979183? 5-Azacytidine embryo development increase embryo development GO:0009790 Homo sapiens It is a potent inducer of cardiomyogenic differentiation in bone marrow-derived mesenchymal stem cells "15023550, 17979183 " 5-Azacytidine embryo development increase embryo development GO:0009790 Homo sapiens ?It is a potent inducer of cardiomyogenic differentiation in both embryonic cells. 17979183? 5-Azacytidine embryo development increase embryo development GO:0009790 Homo sapiens It is a potent inducer of cardiomyogenic differentiation in adult stem cells. 17979183? 5-Methylcytosine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 "6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox)" embryo development affect embryo development GO:0009790 Mus musculus "Co-treatment with noncytotoxic concentrations of AgNPs (10 米M) and MeHg (0.1 米M) triggered apoptotic processes and embryotoxicity in mouse blastocysts and evoked intracellular reactive oxygen species (ROS) generation, which was effectively blocked by preincubation with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox), a classic antioxidant. " 35782646 6MQT embryo development not blastocyst development GO:0001824 Mus musculus "In vitro fertilization (IVF) experiments using Swiss albino mice revealed that spermatozoa processed with 6MQT had non-significantly higher blastocyst rate and a superior blastocyst quality. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))" 33237520 7-Methylguanosine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 9-cis RA (9c-RA) embryo development increase embryo development GO:0009790 Mus musculus increase the number of cardiomyocytes during mouse ES cell differentiation 17979183? Acetyl phosphate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Acetylcarnitine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Acetylcarnitine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Acetylcarnitine embryo development increase embryo development GO:0009790 Mus musculus "the antioxidant combination Acetyl-L-Carnitine, N-Acetyl-L-Cysteine and 汐-Lipoic Acid in embryo culture media was shown to significantly improve mouse embryo development and viability" "29136144, 27165621" Aconitic acid embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Actinomycin D embryo development decrease embryo development GO:0009790 Mus musculus Mouse embryo is very sensitive to actinomycin D: at low concentrations the antibiotic blocks the development of the embryo in culture at early stages. The development of the embryos in culture was markedly depressed after continuous incubation with 0.01 and 0.1 米g/ml of actinomycin D. "563792, 5461023" Adenosine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 ADP embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 ADP embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 ADP-ribose embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 ADP-ribose embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 AICAR embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Air Pollutants embryo development decrease neural tube development GO:0021915 Homo sapiens Coal results in increased abundance of Smoke which results in increased abundance of Air Pollutants which results in decreased neural tube development] 24307569 Alanine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Alanine embryo development relate embryo development GO:0009790 Homo sapiens The IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization). 18842260 All- trans retinoic acid (ATRA) embryo development increase embryo development GO:0009790 Mus musculus increase the number of cardiomyocytes during mouse ES cell differentiation 17979183? All- trans retinoic acid (ATRA) embryo development decrease embryo development GO:0009790 Homo sapiens "Using human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB) as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds. The results showed that the compounds differentially repressed cell growth, compromised morphology, and triggered apoptosis in the EBs." 34742744 Allura Red AC Dye embryo development decrease embryonic morphogenesis GO:0048598 Mus musculus Allura Red AC Dye results in decreased embryonic morphogenesis 28927898 Alpha lipoic Acid embryo development increase embryo development GO:0009790 Mus musculus "the antioxidant combination Acetyl-L-Carnitine, N-Acetyl-L-Cysteine and 汐-Lipoic Acid in embryo culture media was shown to significantly improve mouse embryo development and viability" "29136144, 27165621" Alpha-aminoisobuturic acid embryo development not embryo development GO:0009790 Mus musculus "Alpha-aminoisobuturic acid, which displays saturation kinetics, was harmless to the blastocysts even at a high concentration." 525368 Alpha-cyano-4-hydroxy cinnamate (4-CIN) embryo development decrease blastocyst growth GO:0001832 Mus musculus "During maturation of cumulus-oocyte-complexes (COCs) with pyruvate, electron transport inhibitor, rotenone or monocarboxylate transfer inhibitor, 4-CIN significantly decreased blastocyst rates. " 26857840 Alpha-Galactose embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Alpha-Glucose embryo development relate embryo development GO:0009790 Homo sapiens The IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization). 18842260 Alpha-ketoglutarate embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus " A decrease of L-2-HG facilitates global erasure of histone methylation during early embryo development. 汐-KG also rescued the L-2-HG effects on blastocyst formation rate, but could not fully rescue the morphological abnormalities, suggesting these two metabolites have certain opposing effects, but may also have other non-antagonizing effects" 34650276 Alpha-ketoglutarate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Alpha-ketoglutarate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Alpha-ketoisovaleric acid embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Alternariol (AOH) embryo development affect embryo development GO:0009790 Mus musculus "Alternariol (AOH) and ochratoxin A (OTA), two mycotoxins found in many foods worldwide, exhibit cytotoxicity and embryotoxicity, triggering apoptosis and cell cycle arrest in several mammalian cells and mouse embryos. " 34956623 Amino Acids embryo development affect embryo development GO:0009790 Mus musculus Amino Acids and Ammonium Regulate Mouse Embryo Development in Culture 8439627 Amino acids embryo development affect trophectodermal cell differentiation GO:0001829 Mus musculus "Exogenous Amino Acids Regulate Trophectoderm Differentiation in the Mouse Blastocyst through an mTOR-Dependent Pathway" 11784055 Amino acids embryo development affect embryo implantation GO:0007566 Mus musculus Amino Acid transport regulates blastocyst implantation 12801981 Amino-oxyacetate embryo development decrease embryo development GO:0009790 Mus musculus "Amino-oxyacetate (AOA), which inhibits the transamination of glutamate to a-ketoglutarate and therefore the metabolism of a substantial number of amino acids, was found to reduce the rates of blastocyst formation at concentrations above 0.5 mM." 8868245 Amitriptyline embryo development affect embryo development GO:0009790 Mus musculus Exposure of mouse embryos in whole embryo culture to amitriptyline caused craniofacial malformations. 1412065 Ammonium embryo development affect embryo development GO:0009790 Mus musculus Ammonium regulate mouse embryo development in culture 8439627 Ammonium embryo development decrease blastocyst development GO:0001824 Homo sapiens Increased ammonium in culture medium may promote cellular apoptosis and negatively affect pluripotency of human blastocysts. 36394664 "Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate" embryo development decrease embryonic placenta development GO:0001892 Mus musculus "Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate affects embryonic placenta development" 32074459 Ammonium chloride embryo development decrease embryo development GO:0009790 Mus musculus "Ammonium has been shown to decrease embryo cleavage and blastocyst development, decrease blastocyst cell number, alter metabolism, and increase apoptosis" 16221986 Ammonium chloride embryo development decrease embryo development GO:0009790 Mus musculus "Exposure to ammonium during the entire preimplantation stage, from the zygote to the blastocyst, also decreases implantation rates and fetal development as well as increasing the incidence of fetal abnormalities" 16221986 AMP embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 AMP embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Aphidicolin embryo development decrease embryonic morphogenesis GO:0048598 Mus musculus Aphidicolin results in decreased embryonic morphogenesis 29990529 Arachidonoylglycerol embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Arginine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Arginine embryo development affect chorionic trophoblast cell proliferation GO:0097360 Mus musculus Arginine is necessary and sufficient for trophoblast outgrowth. "22056783, 36430764, 442281" Arginine embryo development affect embryo development GO:0009790 Mus musculus Arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. "22056783, 442281" Arginine embryo development affect embryo development GO:0009790 Mus musculus Arginine was needed for outgrowth of the mouse blastocyst in vitro. "7799310, Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343." Arsenic embryo development affect DNA methylation involved in embryo development GO:0043045 Homo sapiens Arsenic affects DNA methylation involved in embryo development 24525453 Aspartate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Aspartate embryo development affect embryo development GO:0009790 Mus musculus Aspartate appeared to be the key amino acids sought by embryos and embryos grown in amino-acid-containing media appeared morphologically normal and their volume increased compared with embryos cultured in the absence of amino acids. 7799310 Atrazine embryo development decrease ectodermal cell fate commitment GO:0001712 Homo sapiens Atrazine results in decreased ectodermal cell fate commitment 34146662 Beta-alanine embryo development affect embryo development GO:0009790 Mus musculus Beta-alanine but not taurine can function as an organic osmolyte in preimplantation mouse embryos cultured from fertilized eggs 12950102 Beta-Glucose embryo development relate embryo development GO:0009790 Homo sapiens The IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization). 18842260 Betaine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Betaine embryo development affect embryo development GO:0009790 Mus musculus "betaine can effectively rescue development of embryos harmed by ethanol, and possibly by restoring global level of genome DNA methylation in blastocysts." 29379082 Betaine embryo development affect DNA methylation involved in embryo development GO:0043045 Mus musculus "betaine can effectively rescue development of embryos harmed by ethanol, and possibly by restoring global level of genome DNA methylation in blastocysts." 29379082 Betaine embryo development affect embryo development GO:0009790 Mus musculus "Betaine (N,N,N-trimethylglycine) has previously been shown to function in cell volume homeostasis in early mouse embryos and also to be a key donor to the methyl pool in the blastocyst. " "24599290, 11984829" Betaine aldehyde embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Bexarotene embryo development decrease embryonic morphogenesis GO:0048598 Mus musculus Bexarotene results in decreased embryonic morphogenesis 26385866 Bictegravir embryo development decrease embryonic morphogenesis GO:0048598 Mus musculus bictegravir results in decreased embryonic morphogenesis 34515794 Biotin embryo development increase embryo development GO:0009790 Mus musculus Significantly higher percentage of zygotes progressed to two-cell stage in both biotin (P?80% of hES cells under adherent culture conditions. " "19252484, 19896224" SDMA-ADMA embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 SDMA-ADMA embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Sedoheptulose 7-phosphate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Serine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Serotonin? embryo development affect heart morphogenesis GO:0003007 Mus musculus Serotonin?(5-HT) may play a role in cardiac morphogenesis during endocardial cushion formation. "8367830, 3209688" Sertraline embryo development affect embryo development GO:0009790 Mus musculus Exposure of mouse embryos in whole embryo culture to sertraline caused craniofacial malformations. 1412065 Silver nanoparticles (AgNPs) embryo development affect embryo development GO:0009790 Mus musculus "Co-treatment with noncytotoxic concentrations of AgNPs (10 米M) and MeHg (0.1 米M) triggered apoptotic processes and embryotoxicity in mouse blastocysts and evoked intracellular reactive oxygen species (ROS) generation, which was effectively blocked by preincubation with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox), a classic antioxidant. " 35782646 Sirtinol embryo development decrease embryonic limb morphogenesis GO:0030326 Mus musculus sirtinol results in decreased embryonic limb morphogenesis 26251326 5'-Methylthioadenosine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 5'-Methylthioadenosine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 S-Methylmethionine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 S-methy-thioadenosine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Smoke embryo development increase neural tube development GO:0021915 Homo sapiens Coal results in increased abundance of Smoke which results in increased abundance of Air Pollutants which results in decreased neural tube development 24307569 Sodium arsenate embryo development decrease neural crest cell fate specification GO:0014036 Mus musculus sodium arsenite results in decreased neural crest cell fate specification 26024302 Sodium butyrate embryo development increase embryo development GO:0009790 Mus musculus NaBu will promote the development of embryos in vitro. 31356635 Sodium fluoride embryo development decrease blastocyst formation GO:0001825 Mus musculus Sodium fluoride significantly reduced blastocyst formation during early embryonic development. 25854509 Sodium nitrite embryo development decrease embryonic cleavage GO:0040016 Mus musculus Sodium Nitrite results in decreased embryonic cleavage 31476334 Sodium nitroprusside embryo development decrease embryo development GO:0009790 Mus musculus sodium nitroprusside significantly decreased blastocyst formation during embryo development. 25180787 Spermidine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Spermidine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Sphingomyelin embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Sphingosine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Sphingosine-1-Phosphate embryo development affect embryo development GO:0009790 Mus musculus Sphingosine-1-Phosphate partly inhibits the effects of ceramide during preimplantation development of murine embryos. 23731666 Sphingosine-1-Phosphate embryo development affect embryo development GO:0009790 Homo sapiens Addition of S1P to human oocyte culture medium significantly reduced fertilization rate although such treatment decreased embryo fragmentation. 20093086 Sphingosyphosphocholine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Stauprimide embryo development affect ESC differentiation N/A Mus musculus "Stauprimide increases the efficiency of definitive endoderm differentiation. They identified a small molecule, named stauprimide, that increases the efficiency of the directed differentiation of mouse and human ESCs in synergy with defined extracellular signaling cues. " "19427291, 19896224" Stauprimide embryo development affect ESC differentiation N/A Mus musculus Stauprimide promotes neural progenitor differentiation from mouse ESCs "19427291, 19896224" Stauprimide embryo development increase ESC differentiation N/A Homo sapiens "Stauprimide increases the efficiency of definitive endoderm differentiation. They identified a small molecule, named stauprimide, that increases the efficiency of the directed differentiation of mouse and human ESCs in synergy with defined extracellular signaling cues. " "19427291, 19896224" Stavudine embryo development affect embryo development GO:0009790 Mus musculus Stavudine affects embryo development 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased forelimb morphogenesis 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased heart morphogenesis 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased hindbrain morphogenesis 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased hindlimb morphogenesis 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased midbrain morphogenesis 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased neural tube development 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased pharyngeal system development 32278789 Stavudine embryo development affect embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased somite development 32278789 Stavudine embryo development affect neural tube development GO:0021915 Mus musculus [Stavudine affects embryo development] which results in decreased neural tube development 32278789 Stavudine embryo development affect pharyngeal system development GO:0060037 Mus musculus [Stavudine affects embryo development] which results in decreased pharyngeal system development 32278789 Stavudine embryo development affect somite development GO:0061053 Mus musculus [Stavudine affects embryo development] which results in decreased somite development 32278789 Stavudine embryo development decrease embryo development GO:0009790 Mus musculus [Stavudine affects embryo development] which results in decreased forebrain morphogenesis 32278789 Strontium chloride embryo development increase embryo development GO:0009790 Mus musculus Six-hour treatment with 10 mmol/L strontium chloride (SrCl2) in Ca2+ alone or in combination with cytochalasin B can well activate nuclear transfer embryos in mice. 23297500 Succinate embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Succinylcholine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Taurine embryo development not embryo development GO:0009790 Mus musculus Beta-alanine but not taurine can function as an organic osmolyte in preimplantation mouse embryos cultured from fertilized eggs 12950102 Tauroursodeoxycholic acid embryo development increase embryo development GO:0009790 Mus musculus Tauroursodeoxycholic acid (TUDCA) improved the developmental competence of mouse embryos by attenuating endoplasmic reticulum (ER) stress-induced apoptosis during preimplantation development 31802346 Tauroursodeoxycholic acid embryo development increase embryo development GO:0009790 Mus musculus Tauroursodeoxycholic acid improves the implantation and live-birth rates of mouse embryos. "26051458, 31802346 " Taxol embryo development affect embryo development GO:0009790 Mus musculus "Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes." 10029682 Tetrachlorodibenzodioxin embryo development decrease prostatic bud formation GO:0060513 Mus musculus Tetrachlorodibenzodioxin results in decreased prostatic bud formation 24928892 Thalidomide embryo development not embryo development GO:0009790 Homo sapiens Thalidomide did not reduce viability in any of the concentrations tested in human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB) 32700165 Thiacloprid embryo development decrease blastocyst development GO:0001824 Mus musculus thiacloprid results in decreased blastocyst development 29061322 Thiacloprid embryo development decrease embryonic cleavage GO:0040016 Mus musculus thiacloprid results in decreased embryonic cleavage 29061322 Thiamethoxam embryo development decrease blastocyst development GO:0001824 Mus musculus Thiamethoxam results in decreased blastocyst development 29061322 Thiamethoxam embryo development decrease embryonic cleavage GO:0040016 Mus musculus Thiamethoxam results in decreased embryonic cleavage 29061322 Thiamine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Thiamine pyrophosphate embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 threonine embryo development related blastocyst growth GO:0001832 Mus musculus "Arginine, cystine, histidine, leucine and threonine were needed for outgrowth of the mouse blastocyst in vitro." "Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343." Retinoic acid embryo development affect regulation of gastrulation GO:0010470 Mus musculus Tretinoin affects regulation of gastrulation 28184906 Retinoic acid embryo development affect endodermal cell differentiation GO:0035987 Homo sapiens Tretinoin affects endodermal cell differentiation 31600526 Retinoic acid embryo development increase neural plate development GO:0001840 Homo sapiens "[[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] affects cell differentiation] which results in increased neural plate development" 31711903 Triacylglycerol embryo development relate embryo development GO:0009790 Mus musculus Triacylglycerol (TAG) were distributed around the brown adipose tissue and in the liver at embryo day?17.5. 19685253 Tributyltin embryo development affect embryonic placenta development GO:0001892 Mus musculus tributyltin affects embryonic placenta development 33720505 Trichostatin A embryo development increase embryo development GO:0009790 Mus musculus Incomplete and inaccurate genomic reprogramming of somatic cell nuclear transfer (SCNT)-generated embryos was improved by trichostatin A treatment. 20505166 Trichostatin A embryo development increase blastocyst development GO:0001824 Mus musculus Trichostatin A treatments resulted in a blastocyst development rate significantly higher than the obtained in the corresponding control group. 20698782 Trichostatin A embryo development decrease positive regulation of convergent extension involved in gastrulation GO:1904105 Mus musculus Trichostatin A results in decreased positive regulation of convergent extension involved in gastrulation 27693483 Trimethylamine N-oxide embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Trimethyllysine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Tri-o-cresyl phosphate embryo development decrease labyrinthine layer development GO:0060711 Mus musculus tri-o-cresyl phosphate results in decreased labyrinthine layer development 31566301 Tri-o-cresyl phosphate embryo development decrease spongiotrophoblast layer development GO:0060712 Mus musculus tri-o-cresyl phosphate results in decreased spongiotrophoblast layer development 31566301 Tryptophane embryo development related embryo development GO:0009790 Mus musculus "Omission of tryptophane from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely." "Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343." "TSP (sodium 3-(trimethyl-2,2,3,3)-1-propionic acid-d4)" embryo development relate embryo development GO:0009790 Homo sapiens The IVF culture media biomarker chemical shifts in 1H NMR spectrum. (Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization). 18842260 Tyrosine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Tyrosine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Tyrosine embryo development related embryo development GO:0009790 Mus musculus "Omission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. " "7799310, Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343." UDP-galactose embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 UDP-N-acetylglucosamine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 UDP-N-acetylglucosamine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 UMP embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 UMP embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Uracil embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Uracil embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Urea embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Uridine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Uridine 2'-phosphate embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Uridine diphosphate glucose embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Valine embryo development related embryo development GO:0009790 Mus musculus "Metabolite dynamics during mouse embryo development (Zygote, 2-cell, 4-cell, 8-cell, Morula, Blastocyst) (Metabolomics data: ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC每Q-TOF-MS))." 36167681 Valine embryo development related embryo development GO:0009790 Mus musculus "Omission of lysine, methionine, phenylalanine, tryptophane and tyrosine from the culture medium markedly reduced blastocyst outgrowth, but did not inhibit it completely; while omission of isolecine and valine reduced the extent of outgrowth only slightly. " "Gwatkin, R. B. L. (1966). Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro.?Journal of Cellular Physiology,?68(3), 335-343." Valine-Norvaline embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Valine-Norvaline embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Valproic acid embryo development decrease positive regulation of convergent extension involved in gastrulation GO:1904105 Mus musculus Valproic Acid results in decreased positive regulation of convergent extension involved in gastrulation 27693483 Valproic acid embryo development decrease embryo development GO:0009790 Homo sapiens Valproic acid reduced viability in human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB). 34742744 Valproic acid embryo development increase blastocyst development GO:0001824 Mus musculus Both the 2?mM VPA (38.3%) and the 100?nM TSA (34.5%) treatments resulted in a blastocyst development rate significantly higher than the obtained in the corresponding control group. 20698782 Verapamil embryo development increase embryo development GO:0009790 Mus musculus "L-type of Ca2+ channel blocker, verapamil have the most striking pro-cardiomyogenic effects in mouse ES cells. " 17979183? Vitamin A embryo development relate embryo development GO:0009790 Homo sapiens "Vitamin A is essential for normal diaphragm development, and it has been hypothesized that disruption of retinoid signaling may contribute to the etiology of the human disorder." 12621107 Vitamin B12 embryo development affect embryo development GO:0009790 Homo sapiens "Micronutrient (folate, B12, B6) deficiencies or insufficiency could influence fetal growth by their effect on folate/methionine metabolism in the mother and the fetus.?" 22418620 Pyridoxine embryo development affect embryo development GO:0009790 Homo sapiens "Micronutrient (folate, B12, B6) deficiencies or insufficiency could influence fetal growth by their effect on folate/methionine metabolism in the mother and the fetus.?" 22418620 Ascorbic acid embryo development increase embryo development GO:0009790 Homo sapiens Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes "12668514, 17979183 " Xanthine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Xanthohumol embryo development affect negative regulation of heterotypic cell-cell adhesion GO:0034115 Homo sapiens xanthohumol affects negative regulation of heterotypic cell-cell adhesion 23503627 Xanthosine embryo development related embryo development GO:0009790 Mus musculus Significantly changed metabolites in the two-cell-like cell (2CLC) compared with ES cells (ESCs) samples (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34428399 Xanthosine embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 XMP embryo development related embryo development GO:0009790 Mus musculus Higher in the blastocyst-stage embryos compared with two-cell embryos (Metabolomics data: liquid chromatography每tandem mass spectrometry (LC每MS/MS)) 34650276 Y 27632 embryo development decrease positive regulation of convergent extension involved in gastrulation GO:1904105 Mus musculus Y 27632 results in decreased positive regulation of convergent extension involved in gastrulation 27693483 Y 27633 embryo development affect embryo development GO:0009790 Homo sapiens Y27632 is one of optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells 21266967 Y 27634 embryo development increase positive regulation of endodermal cell differentiation GO:1903226 Homo sapiens Y 27632 co-treated with BMP4 protein results in increased positive regulation of endodermal cell differentiation 29143419 Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K28 were elevated 31058416 Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K28 were elevated 31058416 Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus "Histone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic" "25155023, 24810297" Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus "Histone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic" "25155023, 24810297" Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus "Histone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic" "25155023, 24810297" Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus "Histone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic" "25155023, 24810297" Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus "Histone methylations were also altered after ZEA treatment: H3K4me2 as well as H3K9me3 and H4K20me1, me2, me3 levels decreased in eggs that were cultured in high-dose ZEA medium. Thus, our results indicated that ZEA decreased egg developmental competence by affecting the epigenetic" "25155023, 24810297" Zearalenone embryo development increase DNA methylation involved in embryo development GO:0043045 Mus musculus "The fluorescence intensity analysis showed that 5-methyl cytosine level increased after ZEA treatment, indicating that the general DNA methylation level increased in the treated eggs. " "25155023, 24810297" Zearalenone embryo development affect changes to DNA methylation involved in embryo development GO:1901538 Mus musculus Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K27 were elevated "31058416, 31419471" Zearalenone embryo development related DNA methylation involved in embryo development GO:0043045 Mus musculus Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The DNA methylation marker 5hmC was decreased. "31058416, 31419471" asparagine embryo development related embryo development GO:0009790 Mus musculus "On day 5 of embryo culture in vitro, asparagine was depleted at significant rates." 7799310 phenylalanine embryo development related embryo development GO:0009790 Mus musculus "On day 5 of embryo culture in vitro, phenylalanine was depleted at significant rates." 7799310 (-)-Matairesinol female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone" female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "[1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects germinal vesicle" 35760214 "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone" female gamete generation decrease oocyte maturation GO:0001556 Mus musculus "[1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone affects meiotic cell cycle process] which results in decreased oocyte maturation" 35760214 "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone" female gamete generation decrease oocyte maturation GO:0001556 Mus musculus "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased oocyte maturation" 35760214 "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone" female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone results in decreased meiotic cell cycle process involved in oocyte maturation" 35760214 1-Palmitoyl-Palmitoyl female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 "2,3',4,4',5-pentachlorobiphenyl" female gamete generation affect oocyte maturation GO:0001556 Mus musculus "Prenatal exposure to 2,3',4,4',5-pentachlorobiphenyl disturbed the maturation process of progeny mouse oocytes in a dose-dependent manner." 31388691 "2,3',4,4',5-pentachlorobiphenyl" female gamete generation affect oocyte DNA methylation N/A Mus musculus "Prenatal exposure to 2,3',4,4',5-pentachlorobiphenyl altered the DNA methylation status of differentially methylated regions in some imprinted genes." 31388691 2-[p-carbonyl-ethyl)-phenylethylamino]-5＆-N-ethylcarboxamidoadenosine (CGS21680) female gamete generation not meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "A dose-response experiment was conducted to assess the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. A noinhibition group, composed of NECA and CGS21680, in which no augmentation of meiotic arrest was observed." 10331459 2-chloro-adenosine female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "a high-inhibition group, composed of adenosine, 2-Cl-Ado, and R-PIA, in which a low percentage of oocytes resumed maturation (0每17% at 750 ?M)" 10331459 2-Furoic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 2-Hydroxypalmitic Acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 "3,4,5-Trimethoxycinnamic acid" female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 3'-AMP female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 3-Methylxanthine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 3-Phenylbutyric Acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 "4,4,14汐-trimethyl-5汐-cholesta-8,24-diene-3汕-ol (lanosterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "7700384, 11988327" Bisphenol F female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus "4,4'-bisphenol F results in increased negative regulation of oocyte maturation" 33476676 "4,4-dimethyl-5汐-22-oxacholesta-8,14,24-trien-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period 11988327 "4,4-dimethyl-5汐-23-oxacholesta-8,14,25-trien-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period 11988327 "4,4-dimethyl-5汐-cholesta-8,14,24-trien-3汕-ol (FF-MAS)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "7700384, 11988327" "4,4-dimethyl-5汐-cholesta-8,14-dien-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "4,4-dimethyl-5汐-cholesta-8,24-dien-3汕-ol (T-MAS)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "7700384, 11988327" "4,4-dimethylcholest-5-en-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "4,4-dimethylcholest-8-en-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "7700384, 11988327" "4,4-dimethylcholesta-5,7-dien-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "4,4-dimethylcholesta-8,14-dien-3汕-ol" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "7700384, 11988327" "4,4'-hexafluorisopropylidene diphenol" female gamete generation decrease primary ovarian follicle growth involved in double layer follicle stage GO:0043929 Mus musculus "4,4'-hexafluorisopropylidene diphenol results in decreased primary ovarian follicle growth involved in double layer follicle stage" 30675821 4-Methylcatechol female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 5-Aminolevulinic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 5-Hydroxylysine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 5-Hydroxymethyl-2-Deoxyuridine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 5'-Methylthioadenosine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 5'-N-ethylcarboxamidoadenosine (NECA) female gamete generation not meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "A dose-response experiment was conducted to assess the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. A noinhibition group, composed of NECA and CGS21680, in which no augmentation of meiotic arrest was observed." 10331459 "6-formylindolo(3,2-b)carbazole" female gamete generation increase preantral ovarian follicle growth GO:0001546 Homo sapiens "6-formylindolo(3,2-b)carbazole results in increased preantral ovarian follicle growth" 29146461 Acetyl-aspartyl-glutamyl-valyl-aspartal female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of oocyte maturation] 29964317 Acyano-4-hydroxy cinnamate (4-CIN) female gamete generation decrease oocyte maturation GO:0001556 Mus musculus Percentages of MII oocytes decreased significantly with increasing concentrations of 4-CIN. 26857840 Adenine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Adenosine female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Uptake and metabolism of adenosine mediate a meiosis-arresting action on mouse oocytes 10331459 Adenosine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Aflatoxin (AF) female gamete generation increase DNA methylation involved in gamete generation GO:0043046 Mus musculus "The fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.?Mycotoxin-contaminated maize (deoxynivalenol (DON) at 3,875 米g/kg, zearalenone (ZEA) at 1,897 米g/kg, and aflatoxin (AF) at 806 米g/kg) was included in diets." "24288346, 24810297" Agmatine Sulfate female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Allantoin female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Alpha-ketoglutarate female gamete generation affect oogenesis GO:0009790 Mus musculus 汐-KG increases the quality and quantity of oocytes in advanced age mice 汐-ketoglutarate delays age-related fertility decline in mammals Alpha-ketoglutarate female gamete generation affect oogenesis GO:0009790 Mus musculus 汐-KG reduces the decline of primary and growing follicles in advanced age mice 汐-ketoglutarate delays age-related fertility decline in mammals Aminocaproic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Amphotericin B female gamete generation increase oocyte maturation GO:0001556 Mus musculus "Amphotericin B induce resumption of meiosis and indicate that they are likely to cause an accumulation of meiosis activating sterols in the cell-enclosed oocytes (CEO), but ketoconazole blocks the production of Meiosis-activating sterol (MAS). " 11026570 Arachidic acid (C20:0) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Arachidonic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Arachidonic acid female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "GV oocytes cultured in medium supplemented with one of PUFAs, arachidonic acid (ARA), resulted in the meiotic defects and decreased accumulation of NFKB activating protein (NKAP). " 35086109 Arachidonic acid (C20:4n6) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Argininosuccinic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Ascorbic acid female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Atrazine female gamete generation affect ovulation from ovarian follicle GO:0001542 Homo sapiens Atrazine affects the reaction [CGB3 protein results in increased ovulation from ovarian follicle] 19368227 Atrazine female gamete generation increase positive regulation of ovulation GO:0060279 Homo sapiens Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased positive regulation of ovulation] 26923738 AY9944-A-7 female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "AY9944-A-7 induced a dose dependent resumption of oocyte meiosis in CEO in the presence of HX, but had no effect on NO." "11133661, 11988327, 10793639" Behenic acid (C22:0) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Beta-Alanine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Betaine female gamete generation affect oocyte maturation. GO:0001556 Mus musculus Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation. 28663368? Biotin female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 bisphenol S female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus bis(4-hydroxyphenyl)sulfone results in increased negative regulation of oocyte maturation 33476676 Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] female gamete generation increase follicle development N/A Mus musculus Activation of the PI3K-Akt-Foxo3 pathway in oocytes and increased follicle development after treatment with bpV(pic) and 740Y-P. 20479243 Bisperoxovanadium (pyridine-2-carboxyl) [bpV(pic)] female gamete generation increase follicle development N/A Mus musculus Activation of dormant primordial follicles after in vitro treatment with bpV(pic) and 740Y-P. 20479243 Bisphenol A female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus bisphenol A results in decreased meiotic cell cycle process involved in oocyte maturation 28178360 Bisphenol A female gamete generation decrease ovarian cumulus expansion GO:0001550 Mus musculus bisphenol A results in decreased ovarian cumulus expansion 29458137 Bisphenol A female gamete generation decrease regulation of oocyte maturation GO:1900193 Mus musculus bisphenol A affects regulation of oocyte maturation 29458137 Bisphenol A female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus bisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] 29458137 Bisphenol A female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus bisphenol A inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II] 29458137 Bisphenol A female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [bisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic anaphase I 29458137 Bisphenol A female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [bisphenol A inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic telophase I 29458137 Bisphenol A female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus bisphenol A results in increased negative regulation of oocyte maturation 29958887 Bisphenol A female gamete generation decrease primary ovarian follicle growth involved in double layer follicle stage GO:0043929 Mus musculus bisphenol A results in decreased primary ovarian follicle growth involved in double layer follicle stage 30675821 Bisphenol A female gamete generation decrease preantral ovarian follicle growth GO:0001546 Mus musculus bisphenol A results in decreased preantral ovarian follicle growth 33718757 Bisphenol A female gamete generation affect oocyte development GO:0048599 Mus musculus "Estrogens can affect neonatal oocyte development. Exposure of neonates to estrogenic compounds such as estradiol (E2), phytoestrogens like genistein?or with synthetic estrogens including diethylstilbestrol (DES)?or bisphenol-A (BPA)?significantly increases the number of multiple oocyte follicles (MOFs) in ovaries of exposed animals when they are examined as adults.?The oocytes in a MOF are believed to be remnants of a germ cell cyst that did not properly separate and instead the oocytes became enclosed together in one follicle. " "11955941, 22406039" Bisphenol F female gamete generation decrease oocyte maturation GO:0001556 Mus musculus bisphenol F results in decreased oocyte maturation 29102535 Bisphenol F female gamete generation decrease oocyte maturation GO:0001556 Mus musculus [bisphenol F results in decreased oocyte maturation] which results in decreased polar body extrusion after meiotic divisions 29102535 BpV(pic) female gamete generation increase follicle development N/A Homo sapiens "In the bpV(pic)-treated group, 4-fold increases in the number of secondary and antral follicles were found. " 20479243 BpV(pic) female gamete generation increase oocyte maturation GO:0001556 Homo sapiens 4- and 27-fold increases in the number of antral follicles and mature (MI and MII) oocytes were found after bpV(pic) treatment. 20479243 Busulfan female gamete generation decrease follicle loss N/A Mus musculus "Treatment with busulfan for 30 days can accelerate the senescence of female mice, down-regulating the expression of estrogen in ovary, decreasing the number of all kinds of follicles." "27806317, 23549849" Butadiene diepoxide female gamete generation affect oocyte chromosome aberrations N/A Mus musculus Induction and transmission of chromosome aberrations in mouse oocytes after treatment with butadiene diepoxide 9435881 Butylbenzyl phthalate female gamete generation increase oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Cadmium female gamete generation increase negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145 Mus musculus Cadmium results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation 29684212 Cadmium Chloride female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Cadmium Chloride results in decreased meiotic cell cycle process involved in oocyte maturation 29287790 Capric acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Carbenoxolone female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Carbenoxolone inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] 29458137 Carbenoxolone female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Carbenoxolone inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II] 29458137 Carbenoxolone female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [Carbenoxolone inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic prophase I 29458137 Carbofuran female gamete generation decrease oocyte microtubule cytoskeleton organization GO:0016325 Mus musculus Carbofuran results in decreased oocyte microtubule cytoskeleton organization 25564422 CEP 33779 female gamete generation decrease oocyte maturation GO:0001556 Mus musculus CEP 33779 results in decreased oocyte maturation 28615348 Chlordecone female gamete generation affect oogenesis GO:0009790 Mus musculus "Increase in 8-oxo-G in embryonic oocytes after CD exposure ( the levels of 8-oxo-G, which is one of the most common lesions produced in DNA)" 31084621 Chlordecone female gamete generation affect oogenesis GO:0009790 Mus musculus Gestational exposure to CD reduces H3K4me3 and H4ac marks in adult oocytes 31084621 Chlordecone female gamete generation affect oogenesis GO:0009790 Mus musculus "To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H7 acetylation after chlordecone exposure." 31084621 Chlordecone female gamete generation decrease oogenesis GO:0009790 Mus musculus "To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H6 acetylation after chlordecone exposure." 31084621 Chlordecone female gamete generation increase oogenesis GO:0009790 Mus musculus "To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H4 acetylation after chlordecone exposure." 31084621 Chlordecone female gamete generation increase oogenesis GO:0009790 Mus musculus "To reveal whether gestational exposure to Chlordecone affects H2Aub, which is also associated with damaged and unsynapsed chromosomes in the meiotic cells, we immunostained the surface spreads for H2Aub and SYCP3 in E15.5 oocytes and observed increase in H2Aub and H3K27me3 and a decrease in H3K4me3 and H5 acetylation after chlordecone exposure." 31084621 Chlorpropham female gamete generation increase ovulation from ovarian follicle GO:0001542 Homo sapiens Chlorpropham inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle] 19368227 "Cholest-5,24-diene-3汕-ol (zymosterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period 11988327 "Cholest-5-ene-3汕,16-diol (16-OH-Cholesterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9603267, 11988327" "Cholest-5-ene-3汕,20,22-trienol (20R,22R)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "Cholest-5-ene-3汕,20,22-trienol (20S,22S)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "Cholest-5-ene-3汕,22-diol (22R-OH-Cholesterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 11988327" "Cholest-5-ene-3汕,22-diol (22S-OH-Cholesterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9788247, 9603267, 11988327" "Cholest-5-ene-3汕,25-diol (25-OH-Cholesterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9603267, 11988327" "Cholest-5-ene-3汕,27-diol (27-OH-Cholesterol)" female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the compound during a 24-h culture period "9603267, 11988327" Cholesterol female gamete generation increase meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Activity of sterols to significantly induce resumption of meiosis in naked mouse oocytes compared with that of a control without the Cholest-5-ene-3汕-ol (cholesterol) during a 24-h culture period "7700384, 11988327" Cholesterol female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Cholesterol can activate WT mouse eggs to escape from MII arrest. 25368174 Cholesterol female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cholic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Choline female gamete generation relate oogenesis GO:0009790 Homo sapiens Oocytes which failed to cleave as an embryo had lower follicular fluid levels of choline than embryos that implanted. 22365382 Chorionic Gonadotropin female gamete generation increase positive regulation of ovulation GO:0060279 Homo sapiens Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased positive regulation of ovulation] 26923738 Chorionic Gonadotropin female gamete generation increase positive regulation of ovulation GO:0060279 Homo sapiens Chorionic Gonadotropin results in increased positive regulation of ovulation 26923738 cis-11-Eicosanoic acid (C20:1) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Aconitic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 cis-Eicosadienoic acid (C20:2) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Citric acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cortisol female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cortisone female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cyclic AMP female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cyclophosphamide female gamete generation decrease follicle loss N/A Mus musculus There was a gradual process of follicle loss and low estradiol in Busulfan/cyclophosphamide (Bu/Cy) -treated mice; this is a profile similar to what is found in women with premature ovarian failure (POF). "23549849, 27806317" Cytidine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Cytosine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Dehydroepiandrosterone female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Dehydroepiandrosterone female gamete generation decrease oocyte maturation GO:0001556 Mus musculus The DHEA-induced impairment of oocyte cytoplasmic maturation was not due to drug toxicity. 26857840 Deoxycholic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Deoxycholic acid glycine conjugate female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Deoxycoformycin female gamete generation affect oocyte maturation GO:0001556 Mus musculus The adenosine deaminase inhibitor deoxycoformycin had opposite effects on oocyte maturation depending on the presence or absence of adenosine 10331459 2'-Deoxycytidine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Deoxynivalenol (DON) female gamete generation increase oocyte DNA methylation N/A Mus musculus General DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.? "24288346, 24810297" DGLA (C20:3n6) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 D-Glucaric acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 D-Glucuronic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 "D-Glucurono-6,3-lactone" female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 D-Glutamic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 DHA (C22:6n3) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Diazooxonorleucine female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] 29458137 Diazooxonorleucine female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Diazooxonorleucine inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II] 29458137 Diazooxonorleucine female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic prophase I 29458137 Diazooxonorleucine female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic metaphase I 29458137 Diazooxonorleucine female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [Diazooxonorleucine inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic telophase I 29458137 Dibutyl Phthalate female gamete generation decrease oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Dibutyryl cAMP female gamete generation increase oocyte maturation GO:0001556 Mus musculus Dibutyryl cAMP stimulated an increase in oocyte maturation. 10331459 Dietary fats female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "The first is oocyte meiotic aneuploidy that then leads to early embryonic loss. The second is an abnormal process distinct from meiotic aneuploidy that also leads to early embryonic loss. The third is fetal growth retardation and brain developmental abnormalities," 23152876 Dietary fats female gamete generation affect oocyte development GO:0048599 Homo sapiens "High fat diet induced metabolic abnormalities, resulting in developmental defects in human oocytes." Diethyl phthalate female gamete generation decrease oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Diethylhexyl phthalate female gamete generation decrease oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Diethylhexyl phthalate female gamete generation increase preantral ovarian follicle growth GO:0001546 Mus musculus Diethylhexyl Phthalate results in increased preantral ovarian follicle growth 28286118 Diethylhexyl phthalate female gamete generation decrease oocyte maturation GO:0001556 Homo sapiens Diethylhexyl Phthalate results in decreased oocyte maturation 26545148 Diethylstilbestrol female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Diethylstilbestrol inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] 29458137 Diethylstilbestrol female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus Diethylstilbestrol inhibits the reaction [[EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation] which results in increased meiotic metaphase II] 29458137 Diethylstilbestrol female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Mus musculus [Diethylstilbestrol inhibits the reaction [EGF protein results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation]] which results in increased meiotic anaphase I 29458137 Diethylstilbestrol female gamete generation affect oocyte development GO:0048599 Mus musculus "Estrogens can affect neonatal oocyte development. Exposure of neonates to estrogenic compounds such as estradiol (E2), phytoestrogens like genistein?or with synthetic estrogens including diethylstilbestrol (DES)?or bisphenol-A (BPA)?significantly increases the number of multiple oocyte follicles (MOFs) in ovaries of exposed animals when they are examined as adults.?The oocytes in a MOF are believed to be remnants of a germ cell cyst that did not properly separate and instead the oocytes became enclosed together in one follicle. " "3764775, 2271729, 22406039" Dihydrotestosterone female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Dihydroxyacetone phosphate female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Diisobutyl phthalate female gamete generation decrease oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Diisodecyl phthalate female gamete generation decrease oocyte development GO:0048599 Mus musculus [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased oocyte development 28013214 Diisodecyl phthalate female gamete generation decrease oocyte maturation GO:0001556 Homo sapiens Diisodecyl phthalate results in decreased oocyte maturation 26545148 Dimethylformamide female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus Dimethylformamide results in increased negative regulation of oocyte maturation 35238128 Dimethylformamide female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus Melatonin inhibits the reaction [Dimethylformamide results in increased negative regulation of oocyte maturation] 35238128 Diuron female gamete generation increase ovulation from ovarian follicle GO:0001542 Homo sapiens Diuron inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle] 19368227 Docosahexaenoic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Dodecanedioic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Dodecanoic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Doxorubicin female gamete generation affect oogenesis GO:0009790 Mus musculus "Oocytes exposed to doxorubicin (DXR), a widely used chemotherapeutic agent, rapidly undergo morphological and biochemical changes via discrete effector signaling pathways consistent with the occurrence of apoptosis" 16439991 Doxorubicin female gamete generation increase negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145 Mus musculus Doxorubicin results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation 28329872 Doxorubicin female gamete generation increase negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145 Mus musculus Doxorubicin results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation 31368505 Eicosapentaenoic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Elaidic acid (C18:1n9t) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Endosulfan female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Endosulfan inhibits the reaction [CGA protein results in increased oocyte maturation] 30266436 EPA (C20:5n3) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Epitalon female gamete generation affect oogenesis GO:0009790 Mus musculus Epitalon decreases the frequency of fragmentation in the post-ovulatory aged oocytes and during parthenogenetic activation Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro Erucic acid (C22:1n9) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Estradiol female gamete generation decrease initiation of primordial ovarian follicle growth GO:0001544 Mus musculus Estradiol inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. 17446182 Estriol female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 estrogens female gamete generation affect oocyte development GO:0048599 Mus musculus "Exposure of female mice to environmental estrogens can alter oocyte development, limiting the number of primordial follicles that can be used for reproduction. " 22406039 Estrone female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Etoposide female gamete generation affect oocyte aneuploidy N/A Mus musculus Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse 10029682 Etoposide female gamete generation affect oocyte chromosomal aberrations N/A Mus musculus Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse 10029682 Etoposide female gamete generation affect male germ cell chromosomal mutation N/A Mus musculus Numerical and structural chromosome aberrations induced by etoposide (VP16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes. 8671760 Fatty acid female gamete generation affect oocyte maturation GO:0001556 Mus musculus "The mouse cumulus-oocyte complexes (COCs) exposed to lipid-rich follicular fluid during their maturation had increased oocyte lipid content, induction of endoplasmic reticulum stress markers, and impaired oocyte nuclear maturation." 22440252 Folic Acid female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Fructose-6-phosphate female gamete generation affect oocyte maturation GO:0001556 Mus musculus Fructose-6-phosphate (F-6-P) can overcome the inhibitory effect of DHEA on ooplasmic maturation 26857840 Fumaric acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Gefitinib female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Gefitinib affects meiotic cell cycle process involved in oocyte maturation 33548356 Gefitinib female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Gefitinib affects meiotic cell cycle process involved in oocyte maturation] which results in decreased meiotic prophase I 33548356 Genistein female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Genistein inhibits the reaction [CGA protein results in increased oocyte maturation] 30266436 Genistein female gamete generation decrease initiation of primordial ovarian follicle growth GO:0001544 Mus musculus Genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. 17446182 Gluconolactone female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glucose female gamete generation affect oocyte maturation GO:0001556 Mus musculus By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation without glucose. 26857840 Glucose female gamete generation relate oogenesis GO:0009790 Homo sapiens Oocytes which failed to cleave as an embryo had higher follicular fluid levels of glucose. 22365382 Glucose female gamete generation relate oogenesis GO:0009790 Homo sapiens Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have lower follicular fluid levels of glucose. 22365382 Glucose 6-phosphate female gamete generation relate oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glutamine female gamete generation increase oocyte maturation GO:0001556 Mus musculus glutamine supports oocyte viability but is not an adequate energy source for the completion of spontaneous meiotic maturation and may be detrimental. 11108555 Glutathione female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glutathione female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Glyceraldehyde female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glycerophosphorylcholine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glycine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glycocholic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Glycolic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 glyphosate female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus glyphosate results in increased negative regulation of oocyte maturation 31352102 glyphosate female gamete generation increase oocyte maturation GO:0001556 Homo sapiens glyphosate inhibits the reaction [CGA protein results in increased oocyte maturation] 30266436 Gossypol female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Gossypol affects meiotic cell cycle process involved in oocyte maturation 34509492 Gossypol female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased polar body extrusion after meiotic divisions 34509492 Gossypol female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased meiotic spindle organization 34509492 Gossypol female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Gossypol affects meiotic cell cycle process involved in oocyte maturation] which results in decreased chromosome organization involved in meiotic cell cycle 34509492 Guanine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Heparin female gamete generation affect oogenesis GO:0009790 Mus musculus Heparin interrupts energy metabolism and meiotic progression and adversely affects subsequent development of oocytes under conditions of elevated cAMP levels in cumulus-oocyte complexes (COCs) after pre-IVM treatment with forskolin. 23559189 Heparin female gamete generation affect oogenesis GO:0009790 Mus musculus Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence 23559189 Heparin female gamete generation affect oogenesis GO:0009790 Homo sapiens Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence 23559189 Hexadecanedioic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 High Fat Diet female gamete generation affect chromosome alignment abnormalities N/A Mus musculus "Mice maintained on a high-fat diet produce oocytes with meiotic spindle and chromosome alignment abnormalities, which will lead to aneuploidy embryos. " 23152876 Histamine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Hyodeoxycholic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Hypotaurine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Hypoxanthine female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs). 10331459 Hypoxanthine female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs). 10331459 Hypoxanthine l-1 female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "AY9944-A-7 stimulated dose dependently (5-25 mumol l-1) COC to resume meiosis when cultured for 22 h in alpha minimal essential medium (alpha-MEM) containing 4 mmol hypoxanthine l-1, a natural inhibitor of meiotic maturation." 10793639 inosine female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Uptake and metabolism of adenosine mediate a meiosis-arresting action on mouse oocytes and inosine mimic the synergistic interaction of adenosine with hypoxanthine. 10331459 Inosinic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Inositol female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Iodoacetate female gamete generation decrease oocyte maturation GO:0001556 Mus musculus The iodoacetate-induced impairment of oocyte cytoplasmic maturation was not due to drug toxicity 26857840 Iprodione female gamete generation increase oocyte maturation GO:0001556 Homo sapiens iprodione promotes the reaction [CGA protein results in increased oocyte maturation] 30266436 isobutylmethylxanthine (IBMX) female gamete generation increase oocyte maturation GO:0001556 Mus musculus "Isobutylmethylxanthine stimulated an increase in oocyte maturation." 10331459 Isocitric acid female gamete generation not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Isoleucine female gamete generation relate oogenesis GO:0009790 Homo sapiens "Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of proline, lactate, leucine and isoleucine, and lower levels of glucose." 22365382 Isoniazid female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Isoniazid results in decreased meiotic cell cycle process involved in oocyte maturation 33771660 Isoproturon female gamete generation increase ovulation from ovarian follicle GO:0001542 Homo sapiens isoproturon inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle] 19368227 Ketoconazole female gamete generation increase oocyte maturation GO:0001556 Mus musculus "Amphotericin B induce resumption of meiosis and indicate that they are likely to cause an accumulation of meiosis activating sterols in the cell-enclosed oocytes (CEO), but ketoconazole blocks the production of Meiosis-activating sterol (MAS). " 11026570 L-3-Phenyllactic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Lactate female gamete generation affect oogenesis GO:0009790 Homo sapiens "While animal studies revealed that, compared with glucose and pyruvate, follicular cells did not particularly rely on lactate for their energy requirements, lactate may, however, have additional, non-metabolic roles in the acidification of the local environment." "34944731, 2081802" Lactate female gamete generation relate oogenesis GO:0009790 Homo sapiens Oocytes which failed to cleave as an embryo had lower follicular fluid levels of lactate than embryos that implanted. 22365382 Lactate female gamete generation relate oogenesis GO:0009790 Homo sapiens Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of lactate. 22365382 L-Aspartyl-L-phenylalanine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Carnitine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Carnitine female gamete generation increase oocyte maturation GO:0001556 Mus musculus "oocytes isolated from the follicles treated with l-carnitine had greater rates of maturity (metaphase II/MII), higher fertilization rates and improved blastocyst development" "22917873, 21613630" Cysteine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Cystine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Dihydroorotic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Dopa female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Leucine female gamete generation relate oogenesis GO:0009790 Homo sapiens Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of leucine. 22365382 Levulinic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Histidine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Lignoceric acid (C24:0) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Linoleic acid (C18:2n6) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Linolenic acid (C18:3n3) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Lipid female gamete generation related oocyte development GO:0048599 Mus musculus There is strong evidence for the utilization of endogenous lipid as an energy substrate by oocytes and early embryos. 19660080 leucine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Lysine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Malic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 L-Palmitoylcarnitine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 phenylalanine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Serine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Tryptophane female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Lutein female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Lysophosphatidic acid female gamete generation increase oogenesis GO:0009790 Homo sapiens Lysophosphatidic Acid is abundant in seminal plasma and follicular fluid. It enhances follicle stimulation. 35903269? Lysophosphatidylcholine female gamete generation relate follicle development N/A Homo sapiens Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development 35906399 Malathion female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Malathion inhibits the reaction [CGA protein results in increased oocyte maturation] 30266436 Melatonin female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Melatonin female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus Melatonin inhibits the reaction [Dimethylformamide results in increased negative regulation of oocyte maturation] 35238128 Melatonin female gamete generation increase oocyte maturation GO:0001556 Mus musculus melatonin comprehensively protected oocyte against the defects induced by nivalenol exposure and improved the oocyte quality during mouse oocyte maturation. Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage? Melatonin female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Melatonin promotes human oocyte maturation. 31361919 Methylmercaptopurine riboside female gamete generation increase oocyte maturation GO:0001556 Mus musculus "MMPR stimulated a significant increase in oocyte maturation." 10331459 MG-132 female gamete generation affect oocyte maturation GO:0001556 Mus musculus "MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes" 12437781 MG-132 female gamete generation affect oocyte aneuploidy N/A Mus musculus The transient inhibition of proteasome-mediated proteolysis during oocyte maturation (OM) by MG-132 resulted in dose-response delays during OM and elevated levels of aneuploid MII oocytes. 12437781 Mono(2-ethyl-6-hydroxyhexyl) phthalate female gamete generation decrease oocyte maturation GO:0001556 Homo sapiens mono(2-ethyl-5-hydroxyhexyl) phthalate results in decreased oocyte maturation 26545148 Mono(2-ethyl-6-oxohexyl)phthalate female gamete generation decrease oocyte maturation GO:0001556 Homo sapiens mono(2-ethyl-5-oxohexyl)phthalate results in decreased oocyte maturation 26545148 Mono-(2-ethylhexyl)phthalate female gamete generation decrease oocyte maturation GO:0001556 Homo sapiens mono-(2-ethylhexyl)phthalate results in decreased oocyte maturation 26545148 Mycophenolic acid female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Homo sapiens in vitro in the cumulus-enclosed oocytes treated with IMPDH inhibitor mycophenolic acid (MPA). Inhibition of IMPDH activity in oocytes and preimplantation embryos compromises oocyte meiotic. 34124077 Mycotoxin female gamete generation increase DNA methylation involved in gamete generation GO:0043046 Mus musculus "The fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.?Mycotoxin-contaminated maize (deoxynivalenol (DON) at 3,875 米g/kg, zearalenone (ZEA) at 1,897 米g/kg, and aflatoxin (AF) at 806 米g/kg) was included in diets." "24288346, 24810297" Mycotoxin citrinin female gamete generation affect oocyte maturation GO:0001556 Mus musculus "The mycotoxin citrinin (CTN), a natural contaminant in foodstuffs and animal feeds, exerts cytotoxic and genotoxic effects on various mammalian cells and embryos. A previous investigation by our group revealed potentially hazardous effects of CTN on mouse oocyte maturation and pre- and post-implantation embryo development via the induction of apoptosis." 29186930 Myristic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Myristic acid female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 n-3 PUFA female gamete generation affect oocyte maturation GO:0001556 Mus musculus exposure of the oocyte during maturation in the ovary to an environment high in n-3 PUFA resulted in altered mitochondrial distribution and calcium levels and increased production of reactive oxygen species. 18073322 n-3 PUFA female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 n-6 PUFA female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 N6-(R-phenylisopropyl)-adenosine (R-PIA) female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "A dose-response experiment was conducted to assess the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. A high-inhibition group, composed of adenosine, 2-Cl-Ado, and R-PIA, in which a low percentage of oocytes resumed maturation (0每17% at 750 ?M)" 10331459 N6-cyclopentyladenosine (CPA) female gamete generation affect meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus "A dose-response experiment was conducted to assess the action of six different adenosine analogs on hypoxanthine-maintained meiotic arrest. An intermediate-inhibition group, composed of APNEA and CPA, in which a modest inhibitory action was observed (30每41% GVB at 750 ?M)." 10331459 N-Acetyl-L-Cysteine female gamete generation increase oogenesis GO:0048477 Mus musculus The addition of NAC after vitrification improves the quality of vitrified mature murine oocytes while its addition prior to vitrification is advised against. 30654800 N-Acetylethylenediamine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 N-Acetylglutamic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 N-acetyl-L-cysteine? female gamete generation affect oogenesis GO:0009790 Mus musculus the frequency of spindle defects decreased in NAC-treated oocytes compared to those without NAC treatment. 30978175 N-Acetyl-L-methionine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 N-Acetylneuraminic acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 NAD+ female gamete generation affect Zygotic H3K27ac N/A Mus musculus NAD+-mediated erasure of zygotic H3K27ac is required for the exit of minor ZGA. NAD+ could cooperate with Sirt1 to remove zyH3K27ac. 36167681 N-Alpha-acetyllysine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Neopterin female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Nervonic acid (C24:1) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 N-Formyl-L-methionine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Nicotinamide female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Nivalenol female gamete generation affect oocyte maturation GO:0001556 Mus musculus nivalenol affects oocyte maturation 35016910 Nivalenol female gamete generation decrease oocyte maturation GO:0001556 Mus musculus [nivalenol affects oocyte maturation] which results in decreased spindle assembly involved in female meiosis 35016910 Nivalenol female gamete generation decrease oocyte maturation GO:0001556 Mus musculus [nivalenol affects oocyte maturation] which results in decreased chromosome localization 35016910 Nivalenol female gamete generation affect oogenesis GO:0009790 Mus musculus Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage? Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage? nonylphenol female gamete generation affect oocyte development GO:0048599 Mus musculus Nonylphenol affects oocyte development 32645552 Norvaline female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Octadecanamide female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Okadaic acid female gamete generation affect oocyte aneuploidy N/A Mus musculus "Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro." 14516070 Oleic acid (C18:1n9c) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Orotic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Oxamate? female gamete generation decrease oocyte maturation GO:0001556 Mus musculus Percentages of MII oocytes decreased significantly with increasing concentrations of oxamte. 26857840 Taxol female gamete generation decrease preantral ovarian follicle growth GO:0001546 Mus musculus Paclitaxel (Taxol) results in decreased preantral ovarian follicle growth 35584731 Palmitic acid female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Palmitoleic acid (C16:1) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Pantothenol female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Patulin female gamete generation decrease oocyte maturation GO:0001556 Mus musculus Patulin results in decreased oocyte maturation 34718031 PD 0166285 female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus PD 0166285 inhibits the reaction [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] 35504548 Pentachlorophenol female gamete generation increase ovulation from ovarian follicle GO:0001542 Homo sapiens Pentachlorophenol inhibits the reaction [CGB3 protein results in increased ovulation from ovarian follicle] 19368227 Pentadecanoic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 perfluorodecanoic acid female gamete generation increase negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145 Mus musculus perfluorodecanoic acid results in increased negative regulation of meiotic cell cycle process involved in oocyte maturation 34358620 Petroselinic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Phosphocholine female gamete generation relate oogenesis GO:0009790 Homo sapiens Oocytes which failed to cleave as an embryo had lower follicular fluid levels of phosphocholine than embryos that implanted. 22365382 procyanidin B2 female gamete generation affect oogenesis GO:0048477 Mus musculus Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension "35971139, 35399525" Progesterone female gamete generation decrease initiation of primordial ovarian follicle growth GO:0001544 Mus musculus Progesterone inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. 17446182 L-Proline female gamete generation relate oogenesis GO:0009790 Homo sapiens Patients (women undergoing IVF treatment) who had a positive pregnancy test were found to have higher follicular fluid levels of proline. 22365382 Prostaglandin E2 female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Prostaglandin F2a female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Putrescine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Pyridoxal 5'-phosphate female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Pyroglutamate female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 pyruvate female gamete generation affect oocyte maturation GO:0001556 Mus musculus pyruvate sustains oocyte cytoplasmic maturation 26857840 quercetin female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Quercetin improves human oocyte in vitro maturation. 33177495 Quinic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Repaglinide female gamete generation affect oocyte maturation GO:0001556 Mus musculus Repaglinide can be considered as an effective agent for in vitro oocyte maturation. 28432599 Resveratrol female gamete generation increase oocyte maturation GO:0001556 Mus musculus Resveratrol induced oocyte maturation in aged mice. 29778389 Resveratrol female gamete generation increase preantral ovarian follicle growth GO:0001546 Homo sapiens Resveratrol results in increased preantral ovarian follicle growth 29146461 Resveratrol female gamete generation increase oocyte maturation GO:0001556 Homo sapiens Resveratrol improved oocyte maturation and quality was examined in aged humans. 29778389 Retinal female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Rhamnose female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Riboflavin female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Guanosine female gamete generation affect oogenesis GO:0048477 Mus musculus Guanosine metabolism by mouse oocytes: metabolic cooperativity between the fully grown oocyte and cumulus cells 7276886 Rotenone female gamete generation decrease oocyte maturation GO:0001556 Mus musculus Percentages of MII oocytes decreased significantly with increasing concentrations of rotenone. 26857840 S-adenosylmethionine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Selenium female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Silver Compounds female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus Silver Compounds results in increased negative regulation of oocyte maturation 29964317 Silver Compounds female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of oocyte maturation] 29964317 Small molecular compound 28 (C28) female gamete generation decrease oogenesis GO:0048477 Mus musculus "The number, viability, and proliferation of FGSCs were significantly reduced in C89-treated groups." 31216656 Small molecular compound 28 (C28) female gamete generation decrease oogenesis GO:0048477 Mus musculus C28 can inhibit the proliferation and reduce?cell viability?of?FGSCs?in vitro by autophagy. 32949695 Small molecular compound 28 (C28) female gamete generation decrease oogenesis GO:0048477 Mus musculus "The expression of genes (Trib3,?DDIT3, and?ATF4) related to endoplasmic reticulum (ER) stress was enhanced by C28." 32949695 Small molecular compound 28 (C28) female gamete generation decrease FGSCs autophagy N/A Mus musculus C28 induced autophagy of FGSCs in vitro. 32949695 Small molecular compound 28 (C28) female gamete generation decrease H3K27 acetylation N/A Mus musculus The changes of histone H3K27 acetylation involves in C28 induced FGSCs autophagy. 31216656 Sodium butyrate female gamete generation decrease oocyte maturation GO:0001556 Mus musculus A high concentration Sodium butyrate will impede the meiosis of oocytes 31356635 Sodium glutamate female gamete generation decrease oocyte maturation GO:0001556 Mus musculus Sodium Glutamate results in decreased oocyte maturation 30733785 Sodium nitrite female gamete generation affect egg coat formation GO:0035803 Mus musculus Sodium Nitrite affects egg coat formation 31476334 Sodium nitrite female gamete generation increase negative regulation of oocyte maturation GO:1900194 Mus musculus Sodium Nitrite results in increased negative regulation of oocyte maturation 31476334 Sorbitol female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Spermidine female gamete generation decrease oogenesis GO:0048477 Mus musculus SPD induces cytoprotective autophagy in FGSCs in vitro. 34099041 Spermine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Sphingosine-1-Phosphate female gamete generation increase oocyte maturation GO:0001556 Mus musculus "Considering the blastulation rate together with the apoptotic event in the blastocysts, adding 100 and 500 nM S1P within oocyte maturation medium could be beneficial in the development of immature mouse oocytes." 21160167 Sphingosine-1-Phosphate female gamete generation increase oogenesis GO:0009790 Mus musculus "Considering the blastulation rate together with the apoptotic event in the blastocysts, adding 100 and 500 nM S1P within oocyte maturation medium could be beneficial in the development of immature mouse oocytes." 21160167 Sphingosine-1-Phosphate female gamete generation affect oogenesis GO:0009790 Mus musculus Local application of sphingosine-1-phosphate protected ovarian follicles from chemotherapy-induced cell death. "16439991, 24336672" Stearic acid female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 "Sterol 14汐-ethyl-5汐-cholest-7-ene-3汕,15汐-diol (ethyldiol)" female gamete generation not oogenesis GO:0048477 Mus musculus "Sterol 14汐-ethyl-5汐-cholest-7-ene-3汕,15汐-diol (ethyldiol), which also inhibits P450-DM, had no effect on GVBD in dbcAMP-arrested mouse oocytes with and without FSH-stimulation." "11133661, 11988327" Succinic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Syringic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 T-2 Toxin female gamete generation decrease oocyte maturation GO:0001556 Mus musculus T-2 Toxin results in decreased oocyte maturation 26138683 Taurine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Taurocholic Acid female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Taxol female gamete generation affect oogenesis GO:0009790 Mus musculus "Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes." 10029682 Testosterone female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Testosterone female gamete generation relate oogenesis GO:0048477 Homo sapiens "Elevated follicular fluid androgen levels (testosterone) were associated with lower quality oocytes, and in particular with oocytes showing a trend toward lower cleavage rates after fertilization" 4011065 Tetrachloroisophthalonitrile female gamete generation increase primary follicle stage GO:0048160 Mus musculus tetrachloroisophthalonitrile results in increased primary follicle stage 30586609 Tetradecanedioic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Thyroxine female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Tricosanoic acid (C23:0) female gamete generation relate oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 Triglyceride female gamete generation affect oocyte maturation GO:0001556 Mus musculus "The mouse cumulus-oocyte complexes (COCs) exposed to lipid-rich follicular fluid during their maturation had increased oocyte lipid content, induction of endoplasmic reticulum stress markers, and impaired oocyte nuclear maturation." 22440252 Trizma acetate female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Tryptophanol female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Uridine female gamete generation affect oogenesis GO:0048477 Mus musculus Uridine blocked 3H-adenosine uptake by oocyte-cumulus cell complexes (OCCs) and cumulus cell-enclosed oocytes (CEOs) by 82-85% 10331459 Uridine female gamete generation not germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) N/A Mus musculus Uridine had no effect on germinal vesicle breakdown (GVB) in cell-enclosed oocytes (CEOs) when meiotic arrest was maintained with hypoxanthine or hypoxanthine plus adenosine but reversed the combined inhibitory action of these purines in denuded oocytes (DOs). 10331459 Uridine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Vitamin E female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 Xanthosine female gamete generation related oogenesis GO:0048477 Mus musculus "Significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Xanthurenic acid female gamete generation Not oogenesis GO:0048477 Mus musculus "Not significantly changed metabolites during meiotic maturation (GV, GVBD, MII) (Metabolomics data: ultra-high-performance liquid chromatography-tandem high-resolution mass spectrometry (UHPLC-HRMS))" 33068521 Zearalenone female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation 35504548 Zearalenone female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus PD 0166285 inhibits the reaction [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] 35504548 Zearalenone female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects Golgi organization 35504548 Zearalenone female gamete generation decrease meiotic cell cycle process involved in oocyte maturation GO:1903537 Mus musculus [Zearalenone results in decreased meiotic cell cycle process involved in oocyte maturation] which affects endoplasmic reticulum organization 35504548 Zearalenone female gamete generation increase DNA methylation involved in gamete generation GO:0043046 Mus musculus "The fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice.?Mycotoxin-contaminated maize (deoxynivalenol (DON) at 3,875 米g/kg, zearalenone (ZEA) at 1,897 米g/kg, and aflatoxin (AF) at 806 米g/kg) was included in diets." "24288346, 24810297" Zearalenone female gamete generation increase oocyte maturation GO:0001556 Mus musculus "The activation rate of maturated oocytes was affected in mice byzearalenone (ZEA) treatment, indicating that ZEA affects egg developmental competence.?" "25155023, 24810297" Zinc female gamete generation increase positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146 Homo sapiens [Inositol co-treated with Folic Acid co-treated with Glutathione co-treated with Selenium co-treated with Ascorbic Acid co-treated with Vitamin E co-treated with Zinc co-treated with Lutein] results in increased positive regulation of meiotic cell cycle process involved in oocyte maturation 26545973 污-Linolenic acid (C18:3n6) female gamete generation not oocyte development GO:0048599 Homo sapiens Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence 23886995 "1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid" fertilization increase acrosome reaction GO:0007340 Mus musculus "1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog affects the reaction [NAADP results in increased acrosome reaction]" 24451262 "1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid" fertilization increase acrosome reaction GO:0007340 Mus musculus "1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog results in increased acrosome reaction" 24451262 "2,3',4,4',5-pentachlorobiphenyl" fertilization increase fertilization GO:0009566 Mus musculus "2,3',4,4',5-pentachlorobiphenyl results in decreased fertilization" 31388691 2-aminoethoxydiphenyl borate fertilization increase acrosome reaction GO:0007340 Mus musculus 2-aminoethoxydiphenyl borate inhibits the reaction [NAADP results in increased acrosome reaction] 24451262 "4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester" fertilization decrease sperm DNA decondensation GO:0035041 Mus musculus "4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester results in decreased sperm DNA decondensation" 29355596 "4,4'-hexafluorisopropylidene diphenol" fertilization increase acrosome reaction GO:0007340 Homo sapiens "4,4'-hexafluorisopropylidene diphenol results in increased acrosome reaction" 32508751 "4,4'-hexafluorisopropylidene diphenol" fertilization increase sperm entry GO:0035037 Homo sapiens "[4,4'-hexafluorisopropylidene diphenol results in increased sperm motility] which results in increased sperm entry" 32508751 4-phenylenediamine fertilization increase negative regulation of fertilization GO:0060467 Mus musculus 4-phenylenediamine results in increased negative regulation of fertilization 35363429 Acetyl-aspartyl-glutamyl-valyl-aspartal fertilization increase negative regulation of fertilization GO:0060467 Mus musculus acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of fertilization] 29964317 Adjudin fertilization affect fertilization GO:0009566 Homo sapiens Adjudin is a potent blocker of Cl? channels: disrupting Cl? ion transport function results in a decline in fertilizing ability in humans in vitro 23117128 Alprostadil fertilization increase sperm entry GO:0035037 Homo sapiens [Alprostadil results in increased sperm motility] which results in increased sperm entry 32508751 Butylbenzyl phthalate fertilization decrease acrosome reaction GO:0007340 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Biotin fertilization increase fertilization GO:0009566 Mus musculus Biotin group had significantly higher fertilization rate compared to control. 30284103 Bisphenol A fertilization decrease acrosome reaction GO:0007340 Mus musculus bisphenol A results in decreased acrosome reaction 27125968 Bisphenol A fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus bisphenol A results in decreased binding of sperm to zona pellucida 28178360 Bisphenol A fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [bisphenol A results in decreased binding of sperm to zona pellucida] 28178360 Bisphenol A fertilization decrease fertilization GO:0009566 Mus musculus Melatonin inhibits the reaction [bisphenol A results in decreased fertilization] 28178360 Bisphenol A fertilization decrease fertilization GO:0009566 Mus musculus bisphenol A results in decreased fertilization 25772901|28178360 Butylbenzyl phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Calcimycin fertilization increase positive regulation of acrosome reaction GO:2000344 Homo sapiens Calcimycin results in increased positive regulation of acrosome reaction 30009954 Cholesterol fertilization increase egg activation GO:0007343 Mus musculus Excess cholesterol induces mouse egg activation and may cause female infertility 25368174 Coenzyme Q11 fertilization decrease fertilization GO:0009566 Mus musculus coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased fertilization] 31557371 Coenzyme Q12 fertilization increase fertilization GO:0009566 Mus musculus coenzyme Q10 results in increased fertilization 31557371 Cyclophosphamide fertilization decrease fertilization GO:0009566 Mus musculus Cyclophosphamide results in decreased fertilization 31557371 Cyclophosphamide fertilization decrease fertilization GO:0009566 Mus musculus coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased fertilization] 31557371 D-cysteine fertilization increase fertilization GO:0009566 Mus musculus " L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. " 25715791 Diethylhexyl phthalate fertilization decrease acrosome reaction GO:0007340 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Dibutyl Phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Dibutyl phthalate fertilization decrease acrosome reaction GO:0007340 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diethyl phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Diethyl phthalate fertilization decrease acrosome reaction GO:0007340 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diethylhexyl phthalate fertilization increase negative regulation of fertilization GO:0060467 Mus musculus Diethylhexyl Phthalate results in increased negative regulation of fertilization 30649530 Diethylhexyl phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Diisobutyl phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Diisodecyl phthalate fertilization increase negative regulation of fertilization GO:0060467 Mus musculus diisononyl phthalate results in increased negative regulation of fertilization 30649530 Diisodecyl phthalate fertilization decrease fertilization GO:0009566 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in decreased fertilization 33711355 Diisodecyl phthalate fertilization decrease fertilization GO:0009566 Homo sapiens Diisodecyl phthalate results in decreased fertilization 26545148 Diisodecyl phthalate fertilization decrease fertilization GO:0009566 Homo sapiens Diisononyl phthalate results in decreased fertilization 26545148 Dimethylformamide fertilization decrease female pronucleus assembly GO:0035038 Mus musculus Dimethylformamide results in decreased female pronucleus assembly 35238128 Dimethylformamide fertilization decrease male pronucleus assembly GO:0035039 Mus musculus Dimethylformamide results in decreased male pronucleus assembly 35238128 Dimethylformamide fertilization increase negative regulation of fertilization GO:0060467 Mus musculus Dimethylformamide results in increased negative regulation of fertilization 35238128 "Enkephalin, D-Penicillamine (2,5)-" fertilization decrease fertilization GO:0009566 Mus musculus "Enkephalin, D-Penicillamine (2,5)- results in decreased fertilization" 32145291 "Enkephalin, D-Penicillamine (2,5)-" fertilization decrease fertilization GO:0009566 Mus musculus "[Enkephalin, D-Penicillamine (2,5)- results in decreased sperm capacitation] which results in decreased fertilization" 32145291 "Enkephalin, D-Penicillamine (2,5)-" fertilization decrease fertilization GO:0009566 Mus musculus "[[Enkephalin, D-Penicillamine (2,5)- results in decreased sperm capacitation] which results in decreased fertilization] which results in decreased cytogamy" 32145291 Ethinyl Estradiol fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Ethinyl Estradiol results in decreased binding of sperm to zona pellucida 31931096 Ethinyl Estradiol fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased binding of sperm to zona pellucida] 31931096 Ethinyl Estradiol fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus [Ethinyl Estradiol results in increased cleavage of ZP2 protein] which results in decreased binding of sperm to zona pellucida 31931096 Ethinyl Estradiol fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [[Ethinyl Estradiol results in increased cleavage of ZP2 protein] which results in decreased binding of sperm to zona pellucida] 31931096 Ethinyl Estradiol fertilization decrease fertilization GO:0009566 Mus musculus Ethinyl Estradiol results in decreased fertilization 31931096 Ethinyl Estradiol fertilization decrease fertilization GO:0009566 Mus musculus Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased fertilization] 31931096 Fenoxaprop ethyl fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [fenoxaprop ethyl results in decreased binding of sperm to zona pellucida] 31265864 Fenoxaprop ethyl fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Fenoxaprop ethyl results in decreased binding of sperm to zona pellucida 31265864 Fipronil fertilization decrease fertilization GO:0009566 Mus musculus Fipronil results in decreased fertilization 32294523 gamma-aminobutyric acid fertilization affect acrosome reaction GO:0007340 Mus musculus "GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation. GABA also promoted the acrosome reaction, which was suppressed by a selective GABA A receptor antagonist." 31178551 Glutathione fertilization increase fertilization GO:0009566 Mus musculus Exposure of oocytes to reduced glutathione (GSH) greatly improves the fertilization rate of frozen-thawed mouse sperm "25715791, 23916252" Isoniazid fertilization decrease fertilization GO:0009566 Mus musculus Isoniazid results in decreased fertilization 33771660 Lavender oil fertilization increase sperm DNA decondensation GO:0035041 Mus musculus lavender oil inhibits the reaction [Malathion results in increased sperm DNA decondensation] 30409133 L-Carnitine fertilization increase fertilization GO:0009566 Homo sapiens "L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis" "29136144, 480318, 15193480, 16152768" Cysteine fertilization increase fertilization GO:0009566 Mus musculus " L-cysteine (L-Cys), D-cysteine (D-Cys) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. " 25715791 Lysophosphatidic acid fertilization increase fertilization GO:0009566 Homo sapiens Lysophosphatidic Acid is abundant in seminal plasma and follicular fluid. It improves oocyte fertilization. 35903269? Malathion fertilization increase sperm DNA decondensation GO:0035041 Mus musculus lavender oil inhibits the reaction [Malathion results in increased sperm DNA decondensation] 30409133 Malathion fertilization increase sperm DNA decondensation GO:0035041 Mus musculus Malathion results in increased sperm DNA decondensation 30409133 Matrines fertilization increase positive regulation of acrosome reaction GO:2000344 Mus musculus Matrines inhibits the reaction [Progesterone results in increased positive regulation of acrosome reaction] 26867864 Melatonin fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [bisphenol A results in decreased binding of sperm to zona pellucida] 28178360 Melatonin fertilization decrease fertilization GO:0009566 Mus musculus Melatonin inhibits the reaction [bisphenol A results in decreased fertilization] 28178360 Melatonin fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [fenoxaprop ethyl results in decreased binding of sperm to zona pellucida] 31265864 Melatonin fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased binding of sperm to zona pellucida] 31931096 Melatonin fertilization decrease binding of sperm to zona pellucida GO:0007339 Mus musculus Melatonin inhibits the reaction [[Ethinyl Estradiol results in increased cleavage of ZP2 protein] which results in decreased binding of sperm to zona pellucida] 31931096 Melatonin fertilization decrease fertilization GO:0009566 Mus musculus Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased fertilization] 31931096 Metformin fertilization not fertilization GO:0009566 Mus musculus no significant differences in the rate of fertilization between the two groups with or without 10 米M metformin. 36393869 NAADP fertilization increase acrosome reaction GO:0007340 Mus musculus NAADP results in increased acrosome reaction 24451262 NAADP fertilization increase acrosome reaction GO:0007340 Mus musculus "1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid analog affects the reaction [NAADP results in increased acrosome reaction]" 24451262 NAADP fertilization increase acrosome reaction GO:0007340 Mus musculus TPCN1 protein affects the reaction [NAADP results in increased acrosome reaction] 24451262 NAADP fertilization increase acrosome reaction GO:0007340 Mus musculus 2-aminoethoxydiphenyl borate inhibits the reaction [NAADP results in increased acrosome reaction] 24451262 NAADP fertilization increase acrosomal vesicle exocytosis GO:0060478 Mus musculus NAADP results in increased acrosomal vesicle exocytosis 24451262 N-Acetyl-L-Cysteine fertilization increase fertilization GO:0009566 Mus musculus "N-Acetyl-L-Cysteine (NAC), results in increased fertilization rates of mouse oocytes. The enhanced fertilization efficiency may be mediated by cysteine reducing disulphide bonds and inducing expansion in the zona pellucida (ZP) of mouse oocytes, with the morphological changes allowing for greater fertilizing ability/activity" "29136144, 25715791" oleic acid fertilization decrease fertilization GO:0009566 Mus musculus Exogenous oleic acids inhibited fertilization of mouse embryos Effect of Fatty Acids on Fertilization and Development of Mouse Embryos In Vitro palmitic acids fertilization decrease fertilization GO:0009566 Mus musculus Exogenous palmitic acids inhibited fertilization of mouse embryos Effect of Fatty Acids on Fertilization and Development of Mouse Embryos?In Vitro pentoxifylline fertilization decrease fertilization GO:0009566 Mus musculus "If PTX was not washed out, fertilization was reduced significantly, yet development of fertilized oocytes was unaffected. If insemination was performed in the presence of PTX both fertilization and development were impaired. " 7844224 perfluorodecanoic acid fertilization increase female pronucleus assembly GO:0035038 Mus musculus perfluorodecanoic acid inhibits the reaction [strontium chloride results in increased female pronucleus assembly] 34358620 phenylhydrazine fertilization decrease fertilization GO:0009566 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased fertilization] 35099105 phenylhydrazine fertilization decrease fertilization GO:0009566 Mus musculus phenylhydrazine results in decreased fertilization 35099105 Phthalic Acids fertilization decrease acrosome reaction GO:0007340 Mus musculus "Phthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development. " 33711355 Polychlorinated Biphenyls fertilization increase negative regulation of fertilization GO:0060467 Homo sapiens Polychlorinated Biphenyls results in increased negative regulation of fertilization 27576526 Progesterone fertilization increase positive regulation of acrosome reaction GO:2000344 Mus musculus Matrines inhibits the reaction [Progesterone results in increased positive regulation of acrosome reaction] 26867864 Progesterone fertilization increase positive regulation of acrosome reaction GO:2000344 Mus musculus Progesterone results in increased positive regulation of acrosome reaction 26867864 Progesterone fertilization increase acrosome reaction GO:0007340 Homo sapiens Progesterone results in increased acrosome reaction 32508751 Progesterone fertilization increase sperm entry GO:0035037 Homo sapiens [Progesterone results in increased sperm motility] which results in increased sperm entry 32508751 Rosmarinic acid fertilization increase negative regulation of acrosome reaction GO:1902225 Homo sapiens rosmarinic acid results in increased negative regulation of acrosome reaction 30009954 Royal jelly fertilization decrease fertilization GO:0009566 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased fertilization] 35099105 Silver Compounds fertilization increase negative regulation of fertilization GO:0060467 Mus musculus Silver Compounds results in increased negative regulation of fertilization 29964317 Silver Compounds fertilization increase negative regulation of fertilization GO:0060467 Mus musculus acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Silver Compounds results in increased negative regulation of fertilization] 29964317 Sodium fluoride fertilization affect acrosome reaction GO:0007340 Mus musculus "Sodium fluoride adversely affects sperm motility, morphology, capacitation, and the acrosome reaction. " 25854509 Sodium fluoride fertilization decrease fertilization GO:0009566 Mus musculus Sodium fluoride significantly reduced the fertilization during early embryonic development. 25854509 Sodium nitrite fertilization increase negative regulation of fertilization GO:0060467 Mus musculus Sodium Nitrite results in increased negative regulation of fertilization 31476334 Sodium nitroprusside fertilization decrease fertilization GO:0009566 Mus musculus sodium nitroprusside significantly decreased the rates of fertilization during embryo development. 25180787 Sphingosine-1-Phosphate fertilization decrease fertilization GO:0009566 Homo sapiens Addition of S1P to human oocyte culture medium significantly reduced fertilization rate although such treatment decreased embryo fragmentation. 20093086 Strontium chloride fertilization increase female pronucleus assembly GO:0035038 Mus musculus strontium chloride results in increased female pronucleus assembly 34358620 Strontium chloride fertilization increase female pronucleus assembly GO:0035038 Mus musculus perfluorodecanoic acid inhibits the reaction [strontium chloride results in increased female pronucleus assembly] 34358620 Tobacco Smoke Pollution fertilization decrease fertilization GO:0009566 Mus musculus Tobacco Smoke Pollution results in decreased fertilization 27589885 Tobacco Smoke Pollution fertilization decrease positive regulation of acrosome reaction GO:2000344 Mus musculus Tobacco Smoke Pollution results in decreased positive regulation of acrosome reaction 27589885 Vitamin D fertilization increase acrosome reaction GO:0007340 Homo sapiens "Vitamin D enhances sperm vitality and the acrosome reaction and reduces the content of triglyceride in spermatozoa, which effectively increases their fertilization ability in the female reproductive tract." "30618415, 19014363" Butadiene diepoxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus "Dose-dependent reductions of tetraploid cells, round spermatids, and elongated spermatids were detected at 7, 21, and 28 d, respectively, reflecting cytotoxic damage on the differentiating spermatogonia compartment." 8614013 "1,25(OH)2D" male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "1,25(OH)2D may enhance sperm motility by promoting the synthesis of ATP both through the cAMP/PKA pathway and the increase in intracellular calcium ions." 30618415 "1,3-butadiene" male gamete generation decrease spermatogenesis GO:0007283 Mus musculus "Butadiene-induced cytotoxic effects on differentiating spermatogonia were shown by a concentration-dependent decrease of round spermatids occurring 21 days after chemical exposure, confirmed by a similar decrease of elongated spermatids measured in testes sampled 7 days later." "9463552, 7556116, 8901893 " 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which results in decreased spermatogenesis 30521419 "1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3)" male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. 1,25(OH)2D3 effects on sperm motility and acrosin activity are VDR-mediated." 19948036 1-naphthol male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens 1-naphthol results in decreased spermatogenesis 15579410 "2,4,5,2',4',5'-hexachlorobiphenyl" male gamete generation affect spermatogenesis GO:0007283 Homo sapiens "2,4,5,2',4',5'-hexachlorobiphenyl affects spermatogenesis" 15687046 "2,6DQT" male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "2 compounds (6MQT and 2,6DQT) exhibited significant beneficial effect on sperm motility enhancement. Both the compounds improved the sperm motility, and enhanced kinetic parameters. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one, 2,6DQT ((4-((2,6-Dichloroquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))" 33237520 25-hydroxyvitamin D male gamete generation decrease spermatogenesis GO:0007283 Mus musculus 25-hydroxyvitamin D deficiency results in decreased spermatogenesis 28655646 2'-Deoxyadenosine male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement." "33237520, 7890078, 9513852" "3,5,6-trichloro-2-pyridinol" male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens "3,5,6-trichloro-2-pyridinol results in decreased spermatogenesis" 15579410 "4-((2-(oTolyloxy)quinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2OQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-(oTolyloxy)quinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2OQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2-(pTolyloxy)quinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2PQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-(pTolyloxy)quinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2PQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2,6-Dichloroquinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2,6CQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2,6-Dichloroquinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2,6CQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (2,6MQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (2,6MQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2-Chloroquinolin-3yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2CQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-Chloroquinolin-3yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2CQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2-Hydroxy-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (2,6HQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-Hydroxy-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (2,6HQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 "4-((2-Hydroxyquinolin-3-yl)methyl)-2-phenyl-2H- 1,2,4-triazol-3(4H)-one (2HQT)" male gamete generation not positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "4-((2-Hydroxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (2HQT) exhibited no significant enhancement in sperm progressive motility and survival." 33237520 4-hydroxybenzophenone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens 4-hydroxybenzophenone results in decreased spermatogenesis 30245359 4-nonylphenol male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis 29029336 4-tert-octylphenol male gamete generation decrease spermatogenesis GO:0007283 Mus musculus 4-tert-octylphenol results in decreased spermatogenesis 29029336 4-tert-octylphenol male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis 29029336 6MQT male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "Quinoline derivative 6MQT has significant sperm motility enhancement property under in vitro conditions. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))" 33237520 6MQT male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "2 compounds (6MQT and 2,6DQT) exhibited significant beneficial effect on sperm motility enhancement. Both the compounds improved the sperm motility, and enhanced kinetic parameters. (6MQT ((4-((2-Chloro-6-methoxyquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one, 2,6DQT ((4-((2,6-Dichloroquinolin-3-yl)methyl)-2-(4-methoxyphenyl)-2H-1,2,4-triazol-3(4H)-one))" 33237520 Acephate? male gamete generation affect sperm DNA aberrations N/A Homo sapiens Extensive use of organophosphorus pesticides (OPs) could alter semen quality and sperm DNA at different stages of spermatogenesis. 28392800 Acetamiprid male gamete generation affect spermatogenesis GO:0007283 Mus musculus acetamiprid affects spermatogenesis 30103633 Adjudin male gamete generation affect sperm capacitation GO:0048240 Homo sapiens Adjudin is a potent blocker of Cl? channels: disrupting Cl? ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro 23117128 Aflatoxin B1 male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Aflatoxin B1 results in decreased spermatogenesis 29274131 Aflatoxin B1 male gamete generation decrease spermatid development GO:0007286 Mus musculus Aflatoxin B1 results in decreased spermatid development 30126036 Alpha lipoic acid male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus Mouse sperm incubation with different doses of Alpha lipoic acid affect motility. 36640903 Vitamin E male gamete generation decrease spermatid development GO:0007286 Mus musculus alpha-Tocopherol (Vitamin E) inhibits the reaction [Methyl Parathion results in decreased spermatid development] 32294493 Ammonium nitrate male gamete generation affect sperm capacitation GO:0048240 Mus musculus ammonium nitrate induce detrimental effects on capacitation status. 32866586 Ammonium nitrate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus ammonium nitrate adversely affects sperm motility and motion kinematics. 32866586 Ammonium sulfate male gamete generation affect sperm capacitation GO:0048240 Mus musculus ammonium sulfate induce detrimental effects on capacitation status. 32866586 Ammonium sulfate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus ammonium sulfate adversely affects sperm motility and motion kinematics. 32866586 Arachidonic acid male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Arachidonic acid (AA) induced a time- and dose-dependent increase in ROS generation by human spermatozoa that led to the promotion of peroxidative damage and a loss of sperm motility. 16895947 Arsenic male gamete generation affect spermatogenesis GO:0007283 Homo sapiens Arsenic affects spermatogenesis 22776062 Arsenic Trioxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Arsenic Trioxide results in decreased spermatogenesis 28956719 Arsenic Trioxide male gamete generation affect spermatid development GO:0007286 Mus musculus Arsenic Trioxide affects spermatid development 32112876 Arsenic Trioxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Arsenic Trioxide results in decreased spermatogenesis 18630931|32112876 Ascorbic Acid male gamete generation decrease spermatid development GO:0007286 Mus musculus Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased spermatid development] 30140404 Ascorbic Acid male gamete generation decrease sperm DNA condensation GO:0035092 Mus musculus Ascorbic Acid inhibits the reaction [phenylhydrazine results in increased sperm DNA condensation] 30140404 Ascorbic Acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ascorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis] 30526067 Ascorbic Acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ascorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis] 30526067 Aspartame male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Aspartame results in decreased spermatogenesis 32951320 Astaxanthine male gamete generation decrease spermatogenesis GO:0007283 Mus musculus astaxanthine results in increased spermatogenesis 33132140 Atrazine male gamete generation decrease spermatocyte division GO:0048137 Mus musculus Atrazine results in decreased spermatocyte division 26518232 Atrazine male gamete generation affect spermatid development GO:0007286 Mus musculus Atrazine affects spermatid development 27655631 Atrazine male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Atrazine results in decreased spermatogenesis 27655631 Benzene male gamete generation affect sperm chromosomal aberrations N/A Homo sapiens "Men exposed to high levels of benzene are more likely to have an abnormal amount of chromosome in their sperm, which impacts fertility and fetal development." 24416599 Butylbenzyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Butylbenzyl phthalate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Bifenthrin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus bifenthrin results in decreased spermatogenesis 32408700 Biotin male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Supplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa 22527895 Biotin male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Biotin can enhance the sperm motility and prolong the survival of frozen-thawed semen samples which may have potential benefit in assisted reproductive technology field. 22527895 bisphenol S male gamete generation decrease spermatogenesis GO:0007283 Mus musculus bis(4-hydroxyphenyl)sulfone results in decreased spermatogenesis 29741722 Bisphenol A male gamete generation decrease spermatogenesis GO:0007283 Mus musculus bisphenol A results in decreased spermatogenesis 22951085 Bisphenol A male gamete generation decrease spermatogenesis GO:0007283 Mus musculus bisphenol A results in decreased spermatogenesis 29741722 Bisphenol A male gamete generation decrease spermatid development GO:0007286 Mus musculus [bisphenol A co-treated with Stigmasterol] results in decreased spermatid development 30245210 Bisphenol A male gamete generation decrease spermatid development GO:0007286 Mus musculus NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatid development] 30245210 Bisphenol A male gamete generation decrease spermatocyte division GO:0048137 Mus musculus [bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division 30245210 Bisphenol A male gamete generation decrease spermatocyte division GO:0048137 Mus musculus NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division] 30245210 Bisphenol A male gamete generation decrease spermatogenesis GO:0007283 Mus musculus bisphenol A results in decreased spermatogenesis 32956838 Bisphenol A male gamete generation affect DNA methylation involved in gamete generation GO:0043046 Homo sapiens Bisphenol A affects DNA methylation involved in gamete generation 28582417 Bisphenol A male gamete generation affect sperm capacitation GO:0048240 Homo sapiens Bisphenol A impairs mature sperm functions by a catSper-relevant mechanism. 27125968 Bisphenol A diglycidyl ether (BADGE) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." 32508751 Bisphenol AF (BPAF) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." "32508751, 32954995" Bisphenol B(BPB) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." "32508751, 32954995" Bisphenol BP (BPBP) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." "32508751, 32954995" Bisphenol C (BPC) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." "32508751, 32954995" Bisphenol G (BPG) male gamete generation affect sperm capacitation GO:0048240 Homo sapiens "BADGE and the five bisphenol analogs BPG, BPAF, BPC, BPB, and BPBP can affect Ca2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function." "32508751, 32954995" Bumetanide male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "bumetanide and furosemide, two blockers of Na(+)/K(+)/Cl(-) cotransporters (NKCC), inhibited all capacitation-associated events, suggesting that these transporters may mediate Cl(-) movements in sperm. " 18957426 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus Busulfan affects spermatogenesis 32416107 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus ferrostatin-1 inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus Deferoxamine inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus sulforaphane inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus Busulfan affects spermatogenesis 35533795 Busulfan male gamete generation affect spermatogenesis GO:0007283 Mus musculus Busulfan affects spermatogenesis 35533795 Busulfan male gamete generation decreae spermatogenesis GO:0007283 Mus musculus "In 1994, Brinster etc. firstly established the azoospermia mice model by busulfan injection, which laid a foundation for the further study in spermatogenesis" "27806317, 7972054, 7972053" Busulfan male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Busulfan results in decreased spermatogenesis 1058559 Butylated hydroxyanisole male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Protective effect of butylated hydroxytoluene on sperm function in human spermatozoa cryopreserved by vitrification technique 24612426 Butylbenzyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis 29029336 Butylbenzyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Butylbenzyl phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Butylbenzyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Cadmium male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Cadmium affects spermatogenesis 31491373 Cadmium male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased spermatogenesis 32199951 Cadmium male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Cadmium results in decreased spermatogenesis 32976933 Cadmium Chloride male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased spermatogenesis 32199951 Caffeine male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement." "33237520, 7890078, 9513849" Calcimycin male gamete generation increase positive regulation of sperm capacitation GO:1902492 Homo sapiens Calcimycin results in increased positive regulation of sperm capacitation 30009954 Cannabidiol male gamete generation affect spermatogenesis GO:0007283 Mus musculus Cannabidiol affects spermatogenesis 34774840 Cannabidiol male gamete generation increase acrosome assembly GO:0001675 Mus musculus Cannabidiol results in increased acrosome assembly 34774840 Cannabinoids male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which results in decreased spermatogenesis 30521419 Catechol male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Exposure of human sperm in vitro to varied concentrations of catechol caused only insignificant changes in sperm motility and viability as compared to those observed on exposure to phenol-hydroquinone. Hence, exposure to catechol appeared to have less toxic effects than those of phenol-hydroquinone." 24416599 Cetrorelix male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [cetrorelix co-treated with testosterone enanthate] results in decreased spermatogenesis 18160741 Cetrorelix male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased spermatogenesis 18160741 Chlorambucil male gamete generation affect male germ-line mutations N/A Mus musculus Chlorambucil effectively induces deletion mutations in male mouse germ cells. "2726748, 2304907, 8552138" Chlorambucil male gamete generation affect male germ-line mutations N/A Mus musculus High-frequency induction of chromosomal rearrangements in mouse germ cells by the chemotherapeutic agent chlorambucil. 8141802? Chlordecone male gamete generation affect spermatogenesis GO:0007283 Mus musculus Chlordecone affects spermatogenesis 29980752 Chlordecone male gamete generation affect spermatogenesis GO:0007283 Mus musculus Chlordecone affects spermatogenesis 29980752 Chloride male gamete generation affect sperm capacitation GO:0048240 Mus musculus Chloride is essential for capacitation and for the capacitation-associated increase in tyrosine phosphorylation 18957426 Chlorodibromomethane male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Trihalomethanes results in increased abundance of chlorodibromomethane] which results in decreased spermatogenesis 31783240 Chloroform male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Trihalomethanes results in increased abundance of Chloroform] which results in decreased spermatogenesis 31783240 Chlorogenic Acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased spermatogenesis] 33242462 Choline male gamete generation affect spermatogenesis GO:0007283 Mus musculus [Choline deficiency co-treated with Methionine deficiency] affects spermatogenesis 33940107 Cisplatin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Cisplatin results in decreased spermatogenesis 31493026 Crocin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus crocin inhibits the reaction [Paraquat results in decreased spermatogenesis] 31911963 Curcumin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Curcumin inhibits the reaction [Cyclophosphamide results in decreased spermatogenesis] 34715073 Curcumin male gamete generation decrease sperm DNA condensation GO:0035092 Mus musculus Curcumin inhibits the reaction [Cyclophosphamide results in decreased sperm DNA condensation] 34715073 Cyclophosphamide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Curcumin inhibits the reaction [Cyclophosphamide results in decreased spermatogenesis] 34715073 Cyclophosphamide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Cyclophosphamide results in decreased spermatogenesis 34715073 Cyclophosphamide male gamete generation decrease sperm DNA condensation GO:0035092 Mus musculus Curcumin inhibits the reaction [Cyclophosphamide results in decreased sperm DNA condensation] 34715073 Cyclophosphamide male gamete generation decrease sperm DNA condensation GO:0035092 Mus musculus Cyclophosphamide results in decreased sperm DNA condensation 34715073 Cyclophosphamide male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Cyclophosphamide results in decreased spermatogenesis 6788612 Cyclopiazonic acid male gamete generation affect spermatogenesis GO:0007283 Mus musculus cyclopiazonic acid affects spermatogenesis 33400354 Cyproterone Acetate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Cyproterone Acetate results in decreased spermatogenesis 6205409 Decabromobiphenyl ether male gamete generation decrease spermatogenesis GO:0007283 Mus musculus decabromobiphenyl ether results in decreased spermatogenesis 25479311 Decabromobiphenyl ether male gamete generation decrease spermatogenesis GO:0007283 Mus musculus decabromobiphenyl ether results in decreased spermatogenesis 31039416 Decabromobiphenyl ether male gamete generation decrease spermatogenesis GO:0007283 Mus musculus decabromobiphenyl ether results in decreased spermatogenesis 34936917 Decabromobiphenyl ether male gamete generation decrease spermatid development GO:0007286 Mus musculus decabromobiphenyl ether results in decreased spermatid development 34936917 Deferoxamine male gamete generation affect spermatogenesis GO:0007283 Mus musculus Deferoxamine inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Desogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Desogestrel co-treated with testosterone enanthate] results in decreased spermatogenesis 11020511 Desogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased spermatogenesis 18160741 Desogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Desogestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Dexamethasone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Dexamethasone results in decreased spermatogenesis 30526067 Dexamethasone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Dexamethasone results in decreased spermatogenesis 30526067 Dexamethasone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ascorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis] 30526067 Dexamethasone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ascorbic Acid inhibits the reaction [Dexamethasone results in decreased spermatogenesis] 30526067 Dextran Sulfate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Dextran Sulfate results in decreased spermatogenesis 28421826 Dextran Sulfate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus gingerol inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis] 28421826 Dextran Sulfate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis] 28421826 Diethylhexyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diethylhexyl phthalate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Dibutyl Phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis 29029336 Dibutyl Phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Dibutyl Phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Dibutyl Phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Dibutyl Phthalate results in decreased spermatogenesis 33331133 Dibutyl Phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased spermatogenesis] 33331133 Dibutyl Phthalate male gamete generation increase sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Dibutyl Phthalate male gamete generation affect spermatid development GO:0007286 Mus musculus Dibutyl Phthalate affects spermatid development 34280466 Dibutyl Phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Dibutyl Phthalate results in increased abundance of monobutyl phthalate] which results in decreased spermatogenesis 17003688 Dichlorodiphenyl Dichloroethylene male gamete generation affect male meiosis chromosome separation GO:0051308 Homo sapiens Dichlorodiphenyl Dichloroethylene affects male meiosis chromosome separation 26535963 Dichlorodiphenyl Dichloroethylene male gamete generation affect spermatogenesis GO:0007283 Homo sapiens Dichlorodiphenyl Dichloroethylene affects spermatogenesis 15687046 Dietary arachidonic acid (AA) male gamete generation affect spermatogenesis GO:0007283 Mus musculus "The effects of dietary AA and DHA on the fertility and spermatogenesis of the D6D-null males. Supplementing 0.2% DHA alone was able to fully restore male fertility, spermiogenesis, sperm morphology, and sperm count in -/- males. This restoration occurred despite very low AA and near depletion of DPAn6, the major HUFA present in +/+ males." 19690334 Dietary docosahexaenoic acid (DHA) male gamete generation affect spermatogenesis GO:0007283 Mus musculus "Supplementing 0.2% DHA alone was able to fully restore male fertility, spermiogenesis, sperm morphology, and sperm count in -/- males." 19690334 Diethyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Diethyl phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Diethyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diethyl phthalate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diethyl phthalate male gamete generation increase sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Diethyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [diethyl phthalate results in increased abundance of monoethyl phthalate] which results in decreased spermatogenesis 18570050 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased spermatogenesis 29029336 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Diethylhexyl phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis] 31175881 Diethylhexyl phthalate male gamete generation affect acrosome assembly GO:0001675 Mus musculus Diethylhexyl Phthalate affects acrosome assembly 32619501 Diethylhexyl phthalate male gamete generation affect spermatogenesis GO:0007283 Mus musculus Diethylhexyl Phthalate results in decreased spermatogenesis 32619501 Diethylhexyl phthalate male gamete generation increase sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis] 35196152 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased spermatogenesis 18570050 Diethylhexyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in decreased spermatogenesis 18570050 Diisobutyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Diisobutyl phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Diisobutyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Diisobutyl phthalate male gamete generation increase sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Diisodecyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatogenesis 30802670 Diisodecyl phthalate male gamete generation decrease spermatid development GO:0007286 Mus musculus [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in decreased spermatid development 30802670 Diisodecyl phthalate male gamete generation decrease sperm capacitation GO:0048240 Mus musculus [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with Dibutyl Phthalate co-treated with diethyl phthalate co-treated with butylbenzyl phthalate] results in increased sperm capacitation 33711355 Diisodecyl phthalate male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "An environmental-related phthalate combination composed of 21 % di(2-ethylhexyl) phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, 15 % dibutyl phthalate, 35 % diethyl phthalate, and 5% benzylbutyl phthalate adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development." 33711355 Dimethoate male gamete generation decrease spermatid development GO:0007286 Mus musculus Dimethoate results in decreased spermatid development 26482405 Dimethyl phosphate male gamete generation decrease spermatid development GO:0007286 Homo sapiens Dimethyl phosphate results in decreased spermatid development 20850521 Dioxins male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Dioxins results in decreased spermatogenesis 21262597 Docosahexaenoic acid male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Docosahexaenoic acid was effective at stimulating ROS generation by human spermatozoa. 16895947 Doxorubicin male gamete generation affect male germ-line mutations N/A Mus musculus Low levels of chromosomal mutations in germ cells derived from doxorubicin-treated stem spermatogonia in the mouse 2295076 Emodin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Emodin results in decreased spermatogenesis 21319176 Endocrine Disruptors male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Endocrine Disruptors results in decreased spermatogenesis 29029336 Enilconazole male gamete generation decrease spermatogenesis GO:0007283 Mus musculus enilconazole results in decreased spermatogenesis 30853599 "Enkephalin, D-Penicillamine (2,5)-" male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "Enkephalin, D-Penicillamine (2,5)- results in decreased sperm capacitation" 32145291 "Enkephalin, D-Penicillamine (2,5)-" male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "[Enkephalin, D-Penicillamine (2,5)- results in decreased sperm capacitation] which results in decreased fertilization" 32145291 "Enkephalin, D-Penicillamine (2,5)-" male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "[[Enkephalin, D-Penicillamine (2,5)- results in decreased sperm capacitation] which results in decreased fertilization] which results in decreased cytogamy" 32145291 Epigallocatechin gallate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Epigallocatechin gallate inhibits the reaction [sodium arsenate results in decreased spermatogenesis] 29040955 Ethylene dichloride male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ethylene dichloride results in decreased spermatogenesis 28973639 Etonogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone decanoate co-treated with etonogestrel] results in decreased spermatogenesis 18438174 Etonogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone undecanoate co-treated with etonogestrel] results in decreased spermatogenesis 20839093 Etonogestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [etonogestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Etoposide male gamete generation affect male germ-line mutations N/A Mus musculus Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. "16311288, 15744785" Ferrostatin-1 male gamete generation affect spermatogenesis GO:0007283 Mus musculus Ferrostatin-1 inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Fipronil male gamete generation decrease sperm capacitation GO:0048240 Mus musculus Fipronil results in decreased sperm capacitation 32294523 Fipronil male gamete generation increase acrosome assembly GO:0001675 Mus musculus Fipronil results in increased acrosome assembly 32294523 Fish Oils male gamete generation increase spermatid development GO:0007286 Homo sapiens Fish Oils results in increased spermatid development 31951274 Flutamide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Flutamide results in decreased spermatogenesis 14585929 fumonisin B1 male gamete generation affect spermatogenesis GO:0007283 Mus musculus fumonisin B1 affects spermatogenesis 35697133 furosemide male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "bumetanide and furosemide, two blockers of Na(+)/K(+)/Cl(-) cotransporters (NKCC), inhibited all capacitation-associated events, suggesting that these transporters may mediate Cl(-) movements in sperm. " 18957426 Gallic Acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis] 35196152 gamma-aminobutyric acid male gamete generation affect sperm capacitation GO:0048240 Mus musculus "Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration. GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation. " 31178551 genistein male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP)? disrupt the eicosanoid pathway in Spermatogonial Stem Cells. 34942354 genistein male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP) increase Spermatogonial Stem Cell differentiation markers. 34942354 genistein male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP) may affect Spermatogonial Stem Cell differentiation by altering eicosanoids. 34942354 Gingerol male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Gingerol inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis] 28421826 Ginsenoside Rg1 male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in decreased spermatogenesis] 33331133 glycidamide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus glycidamide results in decreased spermatogenesis 35032568 glyphosate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus glyphosate results in decreased spermatogenesis 29908847 glyphosate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus glyphosate results in decreased spermatogenesis 30785197 Hydrogen Sulfide male gamete generation affect spermatogenesis GO:0007283 Mus musculus "Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which affects spermatogenesis]" 33068716 Hydrogen Sulfide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased spermatogenesis 33068716 Hypotaurine? male gamete generation increase sperm DNA condensation GO:0035092 Homo sapiens "Hypotaurine supplementation limited cryo-capacitation, increased the proportion of live and progressively motile spermatozoa and reduces the percentage of spermatozoa showing chromatin decondensation, DNA fragmentation and nuclear vacuolation." "34732137, 23760160 " Icariin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased spermatogenesis] 31175881 Lanthanum oxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus lanthanum oxide results in decreased spermatogenesis 32741894 Lavender oil male gamete generation decrease spermatogenesis GO:0007283 Mus musculus lavender oil inhibits the reaction [Malathion results in decreased spermatogenesis] 30409133 Lavender oil male gamete generation decrease spermatid development GO:0007286 Mus musculus lavender oil inhibits the reaction [Malathion results in decreased spermatid development] 30409133 L-Carnitine male gamete generation increase sperm capacitation GO:0048240 Homo sapiens "L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis" "29136144, 480318, 15193480, 16152768" L-Carnitine male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "L-Carnitine (LC), present in the epididymal fluid, support sperm motility, maturation and fertilization, and protect against oxidative damage by reducing apoptosis" "29136144, 480318, 15193480, 16152768" Lead male gamete generation affect spermatogenesis GO:0007283 Mus musculus [lead chloride results in increased abundance of Lead] which affects spermatogenesis 31647946 Lead male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 32142724 Lead male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 32142724 Lead male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 34508822 Lead male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis] 34508822 Lead male gamete generation affect DNA methylation involved in gamete generation GO:0043046 Homo sapiens Lead affects DNA methylation involved in gamete generation 26417717 Lead male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Lead results in decreased spermatogenesis 32976933 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus lead acetate results in decreased spermatogenesis 22806249 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus lead acetate results in decreased spermatogenesis 22806249 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 32142724 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 32142724 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis 34508822 lead acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis] 34508822 lead chloride male gamete generation affect spermatogenesis GO:0007283 Mus musculus [lead chloride results in increased abundance of Lead] which affects spermatogenesis 31647946 Levonorgestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Levonorgestrel co-treated with testosterone enanthate] results in decreased spermatogenesis 11020511 Levonorgestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone undecanoate co-treated with Levonorgestrel] results in decreased spermatogenesis 10931079|17504903 Levonorgestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone enanthate co-treated with Levonorgestrel] results in decreased spermatogenesis 15867009 Levonorgestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Levonorgestrel promotes the reaction [testosterone enanthate results in decreased spermatogenesis] 10386821 Levonorgestrel male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Levonorgestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Linoleic acid male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Linoleic acid was effective at stimulating ROS generation by human spermatozoa. This effect was observed in the absence of any significant impact on sperm viability, with the exception of the highest dose tested" 16895947 Lysophosphatidic acid male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens LPA significantly improved the motility parameters of human sperm hyperactivation in a dose-dependent manner. The LPA-induced elevation of sperm motility is dependent on bovine serum albumin (BSA) but independent of the classical BSA-induced sAC/cAMP/PKA signaling pathway.? 35903269? Lysophosphatidylcholine (LPC 16:0) male gamete generation relate spermatogenesis GO:0007283 Homo sapiens Ratio of LPC 16:0 to PC 16:0/22:6 Increased in sperm with damaged membrane structure. "34445473, 12472619" Lysophosphatidylcholine (LPC 22:6) male gamete generation relate spermatogenesis GO:0007283 Homo sapiens Ratio of LPC 22:6 to PC 16:0/22:6 increased in sperm with damaged membrane structure. "34445473, 12472619" Lysophosphatidylcholine (PC 16:0/22:6) male gamete generation relate spermatogenesis GO:0007283 Homo sapiens Ratio of LPC 16:0 to PC 16:0/22:6 and ratio of LPC 22:6 to PC 16:0/22:6 Increased in sperm with damaged membrane structure. "34445473, 12472619" Malathion male gamete generation decrease spermatogenesis GO:0007283 Mus musculus lavender oil inhibits the reaction [Malathion results in decreased spermatogenesis] 30409133 Malathion male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Malathion results in decreased spermatogenesis 30409133 Malathion male gamete generation decrease spermatid development GO:0007286 Mus musculus lavender oil inhibits the reaction [Malathion results in decreased spermatid development] 30409133 Malathion male gamete generation decrease spermatid development GO:0007286 Mus musculus Malathion results in decreased spermatid development 30409133 Mancozeb male gamete generation decrease spermatogenesis GO:0007283 Mus musculus mancozeb results in decreased spermatogenesis 30037311 Manganese male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [manganese chloride results in increased abundance of Manganese] which results in decreased spermatogenesis 32445656 Manganese male gamete generation affect spermatogenesis GO:0007283 Mus musculus [manganese chloride results in increased abundance of Manganese] which affects spermatogenesis 34822792 Manganese male gamete generation affect spermatogenesis GO:0007283 Mus musculus YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis] 34822792 Manganese chloride male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [manganese chloride results in increased abundance of Manganese] which results in decreased spermatogenesis 32445656 Manganese chloride male gamete generation affect spermatogenesis GO:0007283 Mus musculus [manganese chloride results in increased abundance of Manganese] which affects spermatogenesis 34822792 Manganese chloride male gamete generation affect spermatogenesis GO:0007283 Mus musculus YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which affects spermatogenesis] 34822792 Matrine male gamete generation affect positive regulation of sperm capacitation GO:1902492 Mus musculus matrine results in decreased positive regulation of sperm capacitation 26867864 Medroxyprogesterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Medroxyprogesterone co-treated with Testosterone] results in decreased spermatogenesis 15535423 Medroxyprogesterone Acetate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Testosterone co-treated with Medroxyprogesterone Acetate] results in decreased spermatogenesis 18438174 Melphalan male gamete generation decrease spermatogenesis GO:0007283 Mus musculus "Melphalan, alone or conjugated to an FSH-汕 peptide, kills murine testicular cells in vitro and transiently suppresses murine spermatogenesis in vivo." 24746827 Melphalan male gamete generation affect male germ-line mutations N/A Mus musculus "Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids." "1378547, 8552138" Methionine male gamete generation affect spermatogenesis GO:0007283 Mus musculus [Choline deficiency co-treated with Methionine deficiency] affects spermatogenesis 33940107 Methyl Parathion male gamete generation decrease spermatid development GO:0007286 Mus musculus alpha-Tocopherol inhibits the reaction [Methyl Parathion results in decreased spermatid development] 32294493 Methyl Parathion male gamete generation decrease spermatid development GO:0007286 Mus musculus Methyl Parathion results in decreased spermatid development 32294493 Miglustat male gamete generation affect spermatogenesis GO:0007283 Mus musculus Miglustat affects spermatogenesis. 17067996 Mitoquinone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Mitoquinone inhibits the reaction [triptolide results in decreased spermatogenesis] 30836114 Mono(2-ethyl-5-hydroxyhexyl) phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate] which results in decreased spermatogenesis 18570050 Mono(2-ethyl-5-oxohexyl)phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased spermatogenesis 18570050 Mono(2-ethylhexyl) phthalate (MEHP) male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP)? disrupt the eicosanoid pathway in Spermatogonial Stem Cells. 34942354 Mono(2-ethylhexyl) phthalate (MEHP) male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP) increase Spermatogonial Stem Cell differentiation markers. 34942354 Mono(2-ethylhexyl) phthalate (MEHP) male gamete generation affect spermatogenesis GO:0007283 Mus musculus Genistein and mono(2-ethylhexyl) phthalate (MEHP) may affect Spermatogonial Stem Cell differentiation by altering eicosanoids. 34942354 Monobutyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus monobutyl phthalate results in decreased spermatogenesis 28496037 Monobutyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Dibutyl Phthalate results in increased abundance of monobutyl phthalate] which results in decreased spermatogenesis 17003688 Monobutyl phthalate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [diethyl phthalate results in increased abundance of monoethyl phthalate] which results in decreased spermatogenesis 18570050 n-3 PUFA male gamete generation affect spermatogenesis GO:0007283 Mus musculus "n-3 PUFA (Fatty Acids, Omega-3) inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which affects spermatogenesis]" 33068716 Nicotine male gamete generation decrease spermatid development GO:0007286 Mus musculus Nicotine results in decreased spermatid development 30896085 Nicotine male gamete generation decrease spermatid development GO:0007286 Mus musculus royal jelly inhibits the reaction [Nicotine results in decreased spermatid development] 30896085 nitric oxide male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Higher concentration of NO reduced sperm cell function, while lower concentration of NO donors enhanced sperm motion and viability." "11369599, 7615122, 8582980" Nitric Oxide male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Nitric Oxide results in decreased spermatogenesis 29983398 Nitrites male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Nitrites results in decreased spermatogenesis 29983398 Norethindrone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Norethindrone co-treated with Testosterone] results in decreased spermatogenesis 15535423 novaluron male gamete generation decrease Sperm capacitation GO:0048240 Mus musculus Novaluron Has Detrimental Effects on Sperm Functions 35010320 Paraquat male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Paraquat results in decreased spermatogenesis 31911963 Paraquat male gamete generation decrease spermatogenesis GO:0007283 Mus musculus crocin inhibits the reaction [Paraquat results in decreased spermatogenesis] 31911963 Parathion male gamete generation affect spermatogenesis GO:0007283 Mus musculus [Parathion results in decreased abundance of Testosterone] which affects spermatogenesis 17375462 Particulate Matter male gamete generation decrease spermatid development GO:0007286 Mus musculus Particulate Matter results in decreased spermatid development 29165613 Particulate Matter male gamete generation decrease spermatocyte division GO:0048137 Mus musculus Particulate Matter results in decreased spermatocyte division 29165613 pentoxifylline male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement." "33237520, 7890078, 9513848" pentoxifylline male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Both biotin and pentoxifylline supplementation resulted in significant increase in total motility (p < 0.05), progressive motility (p < 0.001) and rapid progressive motility (p < 0.05 v/s biotin and p < 0.01 v/s pentoxifylline) compared to the control at 1 h post-incubation period. " "22527895, 12031048, 8530658" perfluorooctane sulfonic acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus perfluorooctane sulfonic acid results in decreased spermatogenesis 27818224 perfluorooctane sulfonic acid male gamete generation decrease spermatogenesis GO:0007283 Mus musculus perfluorooctane sulfonic acid results in decreased spermatogenesis 33359577 perfluorooctanoic acid male gamete generation decrease spermatid development GO:0007286 Homo sapiens Perfluorooctanoic acid results in decreased spermatid development 31841032 Pesticides male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [PON1 protein polymorphism results in increased susceptibility to Pesticides] which results in decreased spermatogenesis 18430447 phenol male gamete generation increase spermatocytes chromosomal aberrations N/A Mus musculus Phenol has been evaluated for genotoxicity in both in vivo and in vitro test systems. Increased chromosomal aberrations have been reported in bone marrow and in spermatocytes from mice treated with phenol. 24416599 phenol-hydroquinone male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Exposure to phenol-hydroquinone caused a significant decline in both, sperm motility and viability. Exposure to a phenol-hydroquinone (Phase I) microenvironment may therefore inhibit metabolically active enzymes, thus impeding ATP production, and in turn lowers sperm motility and viability. " 24416599 phenylhydrazine male gamete generation decrease spermatid development GO:0007286 Mus musculus phenylhydrazine results in decreased spermatid development 30140404 phenylhydrazine male gamete generation decrease spermatid development GO:0007286 Mus musculus Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased spermatid development] 30140404 phenylhydrazine male gamete generation increase sperm DNA condensation GO:0035092 Mus musculus phenylhydrazine results in increased sperm DNA condensation 30140404 phenylhydrazine male gamete generation increase sperm DNA condensation GO:0035092 Mus musculus Ascorbic Acid inhibits the reaction [phenylhydrazine results in increased sperm DNA condensation] 30140404 phenylhydrazine male gamete generation increase spermatogenesis GO:0007283 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased spermatogenesis] 35099105 phenylhydrazine male gamete generation increase spermatogenesis GO:0007283 Mus musculus phenylhydrazine results in decreased spermatogenesis 35099105 phenylhydrazine male gamete generation increase sperm DNA condensation GO:0035092 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased sperm DNA condensation] 35099105 phenylhydrazine male gamete generation increase sperm DNA condensation GO:0035092 Mus musculus phenylhydrazine results in decreased sperm DNA condensation 35099105 Phthalic Acids male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "Phthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development. " 33711355 Phthalic Acids male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "Phthalate mixtures adversely affected sperm motility, capacitation, and acrosome reaction, which resulted in poor fertilization rates and repressed embryonic development. " 33711355 Polychlorinated Biphenyls male gamete generation affect male meiosis chromosome separation GO:0051308 Homo sapiens Polychlorinated Biphenyls affects male meiosis chromosome separation 26535963 Polychlorinated Dibenzodioxins male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Polychlorinated Dibenzodioxins results in decreased spermatogenesis 27713107 Progestins male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Progestins co-treated with Testosterone analog] results in decreased spermatogenesis 3297020 Progestins male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Progestins co-treated with Testosterone] results in decreased spermatogenesis 15572414 Progestins male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Testosterone co-treated with Progestins] results in decreased spermatogenesis 16318399 Prostaglandin D2 male gamete generation affect male germ-line stem cell asymmetric division GO:0048133 Mus musculus Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis 25142465 quinalphos male gamete generation affect spermatogenesis GO:0007283 Mus musculus quinalphos affects spermatogenesis 34014595 quinalphos male gamete generation affect spermatogenesis GO:0007283 Mus musculus [quinalphos affects spermatogenesis] which affects sperm head 34014595 Quinoline Derivative? male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Quinoline derivative enhances human sperm motility and improves the functional competence 33237520 resmethrin male gamete generation decrease spermatogenesis GO:0007283 Mus musculus resmethrin results in decreased spermatogenesis 31593228 Resveratrol male gamete generation affect spermatogonial stem cells (SSCs) activity N/A Mus musculus " Resveratrol changes spermatogonial stem cells activity and ameliorates their loss in busulfan-induced infertile mouse." 27806317 Retinoic acid male gamete generation increase spermatogenesis GO:0007283 Mus musculus Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production 25519186 Retinoic acid male gamete generation affect spermatogonial cell division GO:0007284 Mus musculus Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse. 20650878? Ritonavir male gamete generation decrease Sperm capacitation GO:0048240 Mus musculus Ritonavir may have negative effects on sperm function through an abnormal increase in tyrosine phosphorylation and phospho-AKT levels. 36198369 Rosmarinic acid male gamete generation increase negative regulation of sperm capacitation GO:1902491 Homo sapiens Rosmarinic acid results in increased negative regulation of sperm capacitation 30009954 Royal jelly male gamete generation decrease spermatid development GO:0007286 Mus musculus royal jelly inhibits the reaction [Nicotine results in decreased spermatid development] 30896085 Royal jelly male gamete generation decrease spermatogenesis GO:0007283 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased spermatogenesis] 35099105 Royal jelly male gamete generation decrease sperm DNA condensation GO:0035092 Mus musculus royal jelly inhibits the reaction [phenylhydrazine results in decreased sperm DNA condensation] 35099105 Sildenafil citrate male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens In vitro studies of sildenafil citrate demonstrate a stimulatory effect on sperm motility with an increase in intracellular cAMP. "18087651, 33663030" Rapamycin male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Sirolimus results in decreased spermatogenesis 17845575 Sodium arsenate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus sodium arsenate results in decreased spermatogenesis 29040955 Sodium arsenate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus epigallocatechin gallate inhibits the reaction [sodium arsenate results in decreased spermatogenesis] 29040955 Sodium arsenate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Sulfur Dioxide co-treated with sodium arsenite] results in decreased spermatogenesis 30195209 Sodium arsenate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus sodium arsenite results in decreased spermatogenesis 32991915 Sodium arsenate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased spermatogenesis] 33242462 Sodium fluoride male gamete generation decrease sperm capacitation GO:0048240 Mus musculus "Short-term exposure of spermatozoa to NaF significantly reduced the intracellular calcium concentration, protein kinase-A activity, and tyrosine phosphorylation of sperm proteins, which were associated with a significant decrease in the rate of capacitation and the acrosome reaction." 25854509 Sodium glutamate male gamete generation decrease primary spermatocyte growth GO:0007285 Mus musculus [Sodium Glutamate affects seminiferous tubule development] which results in decreased primary spermatocyte growth 24502529 Sodium glutamate male gamete generation increase spermatogenesis GO:0007283 Mus musculus Sodium Glutamate results in increased spermatogenesis 24502529 Sodium nitroprusside male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Sodium nitroprusside suppresses male fertility in vitro. 25180787 Sodium nitroprusside male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus "sodium nitroprusside inhibited sperm motility and motion kinematics in a dose-dependent manner by significantly enhancing intracellular iron and reactive oxygen species (ROS), and decreasing Ca2+, and adenosine triphosphate levels in spermatozoa." 25180787 sodium sulfide male gamete generation affect spermatogenesis GO:0007283 Mus musculus "Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which affects spermatogenesis]" 33068716 sodium sulfide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased spermatogenesis 33068716 Stigmasterol male gamete generation decrease spermatid development GO:0007286 Mus musculus [bisphenol A co-treated with Stigmasterol] results in decreased spermatid development 30245210 Stigmasterol male gamete generation decrease spermatid development GO:0007286 Mus musculus NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatid development] 30245210 Stigmasterol male gamete generation decrease spermatocyte division GO:0048137 Mus musculus [bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division 30245210 Stigmasterol male gamete generation decrease spermatocyte division GO:0048137 Mus musculus NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased spermatocyte division] 30245210 Sucrose male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Mus musculus Sucrose can be used as effectively as raffinose for mouse sperm cryopreservation. 30036078 Sulfasalazine male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Sulfasalazine results in decreased spermatogenesis 28421826 Sulfasalazine male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased spermatogenesis] 28421826 Sulfogalactosylglycerolipid male gamete generation affect spermatogenesis GO:0007283 Mus musculus Sperm sulfogalactosylglycerolipid (SGG) is involves in direct binding to the zona pellucida (ZP). 10859254 Sulfogalactosylglycerolipid male gamete generation relate spermatogenesis GO:0007283 Mus musculus Sulfogalactosylglycerolipid (SGG) is higher in the group of sperm with higher fertilization capacity. "34445473, 15525814" Sulfogalactosylglycerolipid male gamete generation affect spermatogenesis GO:0007283 Homo sapiens Sulfogalactosylglycerolipid (SGG) is involved in human gamete interaction. 11746968 Sulforaphane male gamete generation affect spermatogenesis GO:0007283 Mus musculus Sulforaphane inhibits the reaction [Busulfan affects spermatogenesis] 32416107 Sulfur Dioxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Sulfur Dioxide results in decreased spermatogenesis 30195209 Sulfur Dioxide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Sulfur Dioxide co-treated with sodium arsenite] results in decreased spermatogenesis 30195209 Testosterone male gamete generation affect spermatogenesis GO:0007283 Mus musculus [Parathion results in decreased abundance of Testosterone] which affects spermatogenesis 17375462 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [FSHB protein co-treated with Testosterone] results in increased spermatogenesis 18667755 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Testosterone deficiency results in decreased spermatogenesis 776749 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Progestins co-treated with Testosterone analog] results in decreased spermatogenesis 3297020 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Progestins co-treated with Testosterone] results in decreased spermatogenesis 15572414 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Testosterone co-treated with Progestins] results in decreased spermatogenesis 16318399 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Testosterone co-treated with Medroxyprogesterone Acetate] results in decreased spermatogenesis 18438174 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Desogestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [etonogestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Norethindrone co-treated with Testosterone] results in decreased spermatogenesis 15535423 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Medroxyprogesterone co-treated with Testosterone] results in decreased spermatogenesis 15535423 Testosterone male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Levonorgestrel co-treated with Testosterone] results in decreased spermatogenesis 15535423 Testosterone male gamete generation increase spermatogenesis GO:0007283 Homo sapiens Testosterone results in increased spermatogenesis 10100480|10465262|1095296|15514086|1597140|2294013|2497224|2612737|2667955|3788416|3928886|6777203 Testosterone decanoate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone decanoate co-treated with etonogestrel] results in decreased spermatogenesis 18438174 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Desogestrel co-treated with testosterone enanthate] results in decreased spermatogenesis 11020511 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Levonorgestrel co-treated with testosterone enanthate] results in decreased spermatogenesis 11020511 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone enanthate co-treated with Levonorgestrel] results in decreased spermatogenesis 15867009 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens testosterone enanthate results in decreased spermatogenesis 3297020 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens testosterone enanthate results in decreased spermatogenesis 10386821|3567493 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens testosterone enanthate results in decreased spermatogenesis 7558380 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Levonorgestrel promotes the reaction [testosterone enanthate results in decreased spermatogenesis] 10386821 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [cetrorelix co-treated with testosterone enanthate] results in decreased spermatogenesis 18160741 Testosterone enanthate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased spermatogenesis 18160741 Testosterone undecanoate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens testosterone undecanoate results in decreased spermatogenesis 10931079|17504903 Testosterone undecanoate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone undecanoate co-treated with Levonorgestrel] results in decreased spermatogenesis 10931079|17504903 Testosterone undecanoate male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [testosterone undecanoate co-treated with etonogestrel] results in decreased spermatogenesis 20839093 Tetrabromobisphenol A male gamete generation decrease spermatogenesis GO:0007283 Mus musculus tetrabromobisphenol A results in decreased spermatogenesis 35230478 Tetrachlorodibenzodioxin male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Tetrachlorodibenzodioxin results in decreased spermatogenesis 27713107 Theobromine male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement." "33237520, 7890078, 9513851" Theophylline male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Pharmacological agents such as pentoxifylline, caffeine, theophylline, theobromine, and 2-deoxyadenosine, which have inhibitory effect on phosphodiesterases, have demonstrated sperm motility enhancement." "33237520, 7890078, 9513850" tin sulfide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus tin sulfide results in decreased spermatogenesis 29069489 titanium dioxide male gamete generation affect spermatogenesis GO:0007283 Mus musculus titanium dioxide affects spermatogenesis 24241477 Tobacco Smoke Pollution male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Tobacco Smoke Pollution results in decreased spermatogenesis 26181561 Retinoic acid male gamete generation affect spermatogenesis GO:0007283 Mus musculus Tretinoin affects spermatogenesis 21228214 Retinoic acid male gamete generation increase spermatogenesis GO:0007283 Mus musculus Tretinoin results in increased spermatogenesis 21277790|6129843 Triclosan male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens Triclosan results in decreased spermatogenesis 26901211 Trihalomethanes male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Trihalomethanes results in increased abundance of Chloroform] which results in decreased spermatogenesis 31783240 Trihalomethanes male gamete generation decrease spermatogenesis GO:0007283 Homo sapiens [Trihalomethanes results in increased abundance of chlorodibromomethane] which results in decreased spermatogenesis 31783240 Triptolide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus triptolide results in decreased spermatogenesis 30836114 Triptolide male gamete generation decrease spermatogenesis GO:0007283 Mus musculus mitoquinone inhibits the reaction [triptolide results in decreased spermatogenesis] 30836114 Vanadium male gamete generation decrease sperm capacitation GO:0048240 Homo sapiens Vanadium adversely affects sperm motility and capacitation status via protein kinase A activity and tyrosine phosphorylation 32659260 Vanadium male gamete generation decrease positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens Vanadium adversely affects sperm motility and capacitation status via protein kinase A activity and tyrosine phosphorylation 32659260 Vitamin A male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Vitamin A results in decreased spermatogenesis 30944279 Vitamin D male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Seminal plasma vitamin D may be involved in regulating sperm motility," 30618415 Vitamin D male gamete generation increase positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Vitamin D enhances sperm vitality and the acrosome reaction and reduces the content of triglyceride in spermatozoa, which effectively increases their fertilization ability in the female reproductive tract." "30618415, 21270327, 27496946" Vitamin D male gamete generation relate positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens "Significant correlation between vitamin D levels and sperm parameters, with a particular emphasis on sperm motility, and partially suggest a relationship between higher serum testosterone and vitamin D levels." "36672602, 31561004, 31190482, 36014783, 27496946" Vitamins male gamete generation affect positive regulation of flagellated sperm motility involved in capacitation GO:0060474 Homo sapiens There was a significant correlation between using vitamins and improved spermatozoa quality; the sperm motility and viability were improved and DNA fragmentation was reduced after thawing by vitamins.? Zearalenone male gamete generation decrease acrosome assembly GO:0001675 Mus musculus Zearalenone results in decreased acrosome assembly 31419471 Zearalenone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus Zearalenone results in decreased spermatogenesis 31419471 Zearalenone male gamete generation decrease spermatogenesis GO:0007283 Mus musculus "Low dose (lower than no-observed effect level, NOEL) of ZEA impaired mouse spermatogenesis and decreased mouse semen quality.?" 28837831 Zinc male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis] 34508822 Zinc Acetate male gamete generation decrease spermatogenesis GO:0007283 Mus musculus [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased spermatogenesis] 34508822 Metformin female gamete generation increase oocyte maturation GO:0001556 Mus musculus metformin treatment of oocytes from aged mice can apparently improve in vitro maturation (IVM) rates. 36393869 quercetin female gamete generation increase oocyte maturation GO:0001556 Mus musculus Treating oocytes from aged mice with quercetin improves oocyte maturation. 33177495