Chemical_name	Reproductive process	Interaction	End_point category	End_point	Mesh ID 	Generation	Descriptions	Species	References
perfluorooctane sulfonate	embryo development	relate	phenotype	Decreased birth weight	N/A	F0	"Higher perfluorooctane sulfonate (PFOS)  and perfluorooctanoate (PFOA) concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. "	Homo sapiens	25372700
perfluorooctanoate	embryo development	relate	phenotype	Decreased birth weight	N/A	F0	"Higher perfluorooctane sulfonate (PFOS)  and perfluorooctanoate (PFOA) concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant.?"	Homo sapiens	25372700
organic pollutants	embryo development	relate	phenotype	Fetal growth decrements	N/A	F0	Maternal levels of Persistent organic pollutants (POPs) during pregnancy are associated with decrements in fetal growth and birth weight.	Homo sapiens	25372700
Aspirin	embryo development	related	disease	"Abnormalities, Drug-Induced"	D000014	F1	Fetal intracranial hemorrhage due to antenatal low dose aspirin intake.	Homo sapiens	11770244
Phenytoin	embryo development	related	disease	"Abnormalities, Multiple"	D000015	F1	Maternal phenytoin ingestion and congenital abnormalities: report of a case.	Homo sapiens	"2492459, 1163515"
Cocaine	embryo development	related	disease	"Abnormalities, Multiple"	D000015	F1	"Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy."	Homo sapiens	14745934
Lithium	embryo development	related	disease	Anencephaly	D000757	F1	Lithium-associated anencephaly	Homo sapiens	15830831
Thorium	embryo development	related	disease	Anencephaly	D000757	F1	Thorium and fetal neural tube defects: an epidemiological evidence from large case-control study.	Homo sapiens	34823609
Nitrofurantoin	embryo development	related	disease	Anophthalmos	D000853	F1	"Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9)."	Homo sapiens	19884587
Phenytoin	embryo development	related	disease	"Anus, Imperforate"	D001006	F1	Maternal phenytoin ingestion and congenital abnormalities: report of a case.	Homo sapiens	1163515
Aspirin	embryo development	related	disease	Aortic Coarctation	D001017	F1	"Aspirin use in early pregnancy was associated with about a twofold increase in the frequency of defects in septation of the truncus arteriosus (prevalence odds ratio, 2.1; 90 per cent confidence interval, 1.1 to 3.9)."	Homo sapiens	4010751
Sulfonamides	embryo development	related	disease	Aortic Coarctation	D001017	F1	"Sulfonamides and nitrofurantoins were associated with several birth defects, indicating a need for additional scrutiny."	Homo sapiens	19884587
Cocaine	embryo development	related	disease	bilateral renal agenesis	C536482	F1	"Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy."	Homo sapiens	14745934
Penicillins	embryo development	not	disease	birth defects	D000013	F1	"Penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. "	Homo sapiens	19884587
Erythromycins	embryo development	not	disease	birth defects	D000013	F1	"Penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. "	Homo sapiens	19884587
Cephalosporins	embryo development	not	disease	birth defects	D000013	F1	"Penicillins, erythromycins, and cephalosporins, although used commonly by pregnant women, were not associated with many birth defects. "	Homo sapiens	19884587
Finasteride	embryo development	related	disease	Bladder Exstrophy	D001746	F1	Newborn with bladder extrophy associated with finasteride exposure	Homo sapiens	15530334
Medroxyprogesterone	embryo development	related	disease	Bladder Exstrophy	D001746	F1	Possible relationship of bladder exstrophy and epispadias with progestins taken during early pregnancy.	Homo sapiens	1873679
17汐-hydroxyprogesterone caproate	embryo development	related	disease	Cancer	N/A	F1	In utero exposure to 17汐-hydroxyprogesterone caproate and risk of cancer in offspring. Exposure in the first trimester was associated with an increased risk of any cancer and and the risk increased with the number of injections.	Homo sapiens	"34767803, 35779586 "
Zidovudine	embryo development	related	disease	Cardiovascular Abnormalities	D018376	F1	In utero exposure to zidovudine and heart anomalies in the ANRS French perinatal cohort and the nested PRIMEVA randomized trial	Homo sapiens	25838291
Air Pollutants	embryo development	related	disease	Cardiovascular Abnormalities	D018376	F1	"Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study."	Homo sapiens	27384219
Nitrofurantoin	embryo development	related	disease	cleft lip with cleft palate 	C535971	F1	"Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9)."	Homo sapiens	19884587
Phenobarbital	embryo development	related	disease	Congenital Abnormalities	D000013	F1	"The study included 22?843 children with congenital abnormalities (cases) and 38?151 children with no abnormalities (controls). Overall, odds ratio (OR) for congenital abnormalities after exposure to one of the three drugs, phenytoin, phenobarbital, or diazepam,  in early pregnancy was 1.2 (95% confidence interval (CI): 1.0每1.4). for children exposed to phenobarbital the OR was 1.1 (95%CI 0.7每1.7)."	Homo sapiens	16941718
phenytoin	embryo development	related	disease	Congenital Abnormalities	D000013	F1	"The study included 22?843 children with congenital abnormalities (cases) and 38?151 children with no abnormalities (controls). Overall, odds ratio (OR) for congenital abnormalities after exposure to one of the three drugs, phenytoin, phenobarbital, or diazepam, in early pregnancy was 1.2 (95% confidence interval (CI): 1.0每1.4). Among children exposed to phenytoin OR for congenital abnormalities was 3.7 (95%CI: 0.3每49.6)."	Homo sapiens	16941718
diazepam	embryo development	related	disease	Congenital Abnormalities	D000013	F1	"The study included 22?843 children with congenital abnormalities (cases) and 38?151 children with no abnormalities (controls). Overall, odds ratio (OR) for congenital abnormalities after exposure to one of the three drugs, phenytoin, phenobarbital, or diazepam, in early pregnancy was 1.2 (95% confidence interval (CI): 1.0每1.4). for congenital abnormalities was 1.2 (95%CI: 1.0每1.4)."	Homo sapiens	16941718
Phenytoin	embryo development	related	disease	Congenital Abnormalities	D000013	F1	Newborn with bladder exstrophy and possible intrauterine exposure to finasteride.	Homo sapiens	1163515
	embryo development	related	phenotype	deficits in IQ	N/A	F1	The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.	Homo sapiens	15644835
Isotretinoin	embryo development	related	disease	ear anomalies	C564519	F1	Fetal hydrocephalus and ear anomalies associated with maternal use of isotretinoin.	Homo sapiens	"6237184, 7499738"
Aluminum	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	"Fetal aluminum exposure may contribute to CHD occurrence. Oxidative stress was related to the concentration of Pb and Al, which may be involved in the occurrence of CHD."	Homo sapiens	"30031113, 26707789"
lead	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	Maternal lead exposure is associated with the risk of some subtypes of CHDs occurrence in offspring. The potential dose-response relationship is also presented.	Homo sapiens	"25462788, 35794301"
Barium	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	Barium exposure increases the risk of congenital heart defects occurrence in offspring.	Homo sapiens	28705031
arsenic	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring.	Homo sapiens	26743994
cadmium	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring.	Homo sapiens	26743994
Indomethacin	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	"Constricting effect of indomethacin on the ductus arteriosus of the fetus is well known. The fetal effects of other nonsteroid anti-inflammatory drugs (NSAIDs) like naproxen are not well reported. We report here a case of a 3,790-g term neonate who developed persistent pulmonary hypertension after birth with a closed ductus arteriosus. The mother admitted to taking naproxen sodium immediately prior to the birth of the infant."	Homo sapiens	11023164
naproxen	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	"Constricting effect of indomethacin on the ductus arteriosus of the fetus is well known. The fetal effects of other nonsteroid anti-inflammatory drugs (NSAIDs) like naproxen are not well reported. We report here a case of a 3,791-g term neonate who developed persistent pulmonary hypertension after birth with a closed ductus arteriosus. The mother admitted to taking naproxen sodium immediately prior to the birth of the infant."	Homo sapiens	11023164
Clomipramine	embryo development	related	disease	"Heart Defects, Congenital"	D006330	F1	Antidepressant drugs during pregnancy and infant congenital heart defect.	Homo sapiens	16406480
Nitrofurantoin	embryo development	related	disease	"Heart Septal Defects, Atrial"	D006344	F1	"Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9)."	Homo sapiens	19884587
Ethinyl Estradiol	embryo development	related	disease	"Heart Septal Defects, Ventricular"	D006345	F1	"After the data were controlled for a wide variety of potentially confounding factors by multivariate methods, the association between in utero exposure to female hormones and cardiovascular birth defects was statistically significant."	Homo sapiens	"830309, 7151638, 6240131"
Isotretinoin	embryo development	related	disease	Hydrocephalus	D006849	F1	Fetal hydrocephalus and ear anomalies associated with maternal use of isotretinoin.	Homo sapiens	"6237184, 7499738"
Nitrofurantoin	embryo development	related	disease	Hypoplastic Left Heart Syndrome	D018636	F1	"Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9)."	Homo sapiens	19884587
Polychlorinated biphenyls	embryo development	related	disease	"Infertility, Female "	D007247	F1	"Polychlorinated biphenyl (PCB) exposure in mothers is related to the time to pregnancy in daughters, decreased probability of pregnancy and higher infertility."	Homo sapiens	21296657
Valproic acid	embryo development	related	disease	"Limb Deformities, Congenital"	D017880	F1	Valproic acid is an anticonvulsant that has been associated with open neural tube defects.?	Homo sapiens	2492459
Phenobarbital	embryo development	related	disease	"Limb Deformities, Congenital"	D017880	F1	The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.	Homo sapiens	15644835
Carbamazepine	embryo development	related	disease	Microcephaly	D008831	F1	"A premature infant exposed to carbamazepine in utero had a markedly undersized brain on cranial ultrasonogram. Postmortem examination of the brain revealed no evidence of hypoxic-ischemic injury, hemorrhage, infarction, congenital infection, or calcification. The normal cortical gyral pattern, normal residual germinal matrix, and normal cortical lamination suggested the diagnosis of a radial microbrain form of micrencephaly."	Homo sapiens	10540608
	embryo development	related	disease	midface hypoplasia	N/A	F1	The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.	Homo sapiens	15644835
17汐-hydroxyprogesterone caproate	embryo development	not	phenotype	neonatal morbidity	N/A	F1	17汐-hydroxyprogesterone caproate does not prevent neonatal morbidity or preterm birth in multiple pregnancies.	Homo sapiens	21860279
17汐-hydroxyprogesterone caproate	embryo development	not	phenotype	preterm birth	N/A	F1	17汐-hydroxyprogesterone caproate does not prevent neonatal morbidity or preterm birth in multiple pregnancies.	Homo sapiens	21860279
Dexamethasone	embryo development	related	disease	Nervous System Malformations	D009421	F1	Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies	Homo sapiens	34742744
Maternal smoking	embryo development	related	disease	Obesity	D009765	F1	"Prenatal maternal smoking represents the proof-of concept for an environmental toxic chemical insult that promotes obesity following exposure during a sensitive developmental window. Multiple studies showed that the adjusted odds ratio for obesity is elevated between 1.5每2.0 in children born to mothers who smoked during pregnancy
and that the risk persists through adulthood."	Homo sapiens	"11980805, 16775040, 16339135"
Cocaine	embryo development	related	disease	Phocomelia	D004480	F1	"Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy."	Homo sapiens	14745934
Glucocorticoids	embryo development	related	phenotype	Reduce birthweight	N/A	F1	Glucocorticoid treatment during pregnancy has been shown to reduce birthweight in animals and humans.	Homo sapiens	11703405
cocaine	embryo development	related	disease	single umbilical artery	D058529	F1	"Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy."	Homo sapiens	14745934
Polychlorinated biphenyls	embryo development	related	phenotype	Time to pregnancy	N/A	F1	"Polychlorinated biphenyl (PCB) exposure in mothers is related to the time to pregnancy in daughters, decreased probability of pregnancy and higher infertility."	Homo sapiens	21296657
Progesterone	oogenesis	related	disease	Disorders of Sex Development	D012734	F1	Female pseudohermaphroditism caused by progesterone therapy of the mother	Homo sapiens	5408743
Hexachlorobenzene	oogenesis	related	disease	"Infertility, Female"	D007247	F0	"Serum concentrations of selected POPs, both as individual chemicals and as a mixture, were significantly associated with lower fecundability and increased odds of infertility in women aged 29?years and above not using COC as their most recent pre-pregnancy contraceptive.?"	Homo sapiens	32539770
Cholesterol	oogenesis	related	disease	"Infertility, Female"	D007247	F0	"The infertility of SR-BI KO females is caused, at least in part, by excess cholesterol in eggs inducing premature activation and that cholesterol can activate WT mouse eggs to escape from MII arrest. Analysis of SR-BI KO female infertility raises the possibility that abnormalities in cholesterol metabolism might underlie some cases of human female infertility of unknown etiology."	Homo sapiens	25368174
Sinapinic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
5'-deoxy-5'-methylthioadenosine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
3-amino-2-piperidone	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Lithocholic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Urocanic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Heptadecanoic acidStearic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Palmitic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Isocitric acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Citroaconic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Hydrocinnamic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Cerotinic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Thymine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Stigmasterol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Pyruvic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Isonicotinic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Dehydroascorbic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Isoxanthopterin	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Pentadecanoic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Cytosin	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Identification of the metabolomics sgnature of human follicular fluid from Polycystic ovary syndrome (PCOS) women with insulin resistance (IR). The expression differences in metabolites among different samples in the PCOS-IR and PCOS-NIR patients. (PCOS patients with IR (PCOS-IR) and  PCOS patients without IR (PCOS-NIR))	Homo sapiens	35465261
Paxilline	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"PC (o-22:0/20:4(8Z,11Z,14Z,17Z))"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"PC (o22:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
LysoPC (16:1(9Z))	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
LysoPC (16:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347, 31186025"
LysoPC (14:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
LysoPC (18:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
"LysoPC (20:4(8Z,11Z,14Z,17Z))"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"PGP (16:0/20:4(5Z,8Z,11Z,14Z)"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Glycerophosphocholine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Ceramide (d18:0/16:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Ceramide (d18:0/24:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Galabiosylceramide (d18:1/24:1(15Z))	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Tetrahexosylceramide (d18:1/24:0)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
7汕-Hydroxycholesterol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Malyl-CoA	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"1-Hydroxy-2,12,15-heneicosatrien-4-one"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
16-hydroxypalmitic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Tridecanol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Carnitine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
4-Hydroxy-3-(16-methylheptadecyl)-2H-pyran-2-one	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Anandamide	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Indan-1-ol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"2-p-Tolyl-1-propene, p-Mentha-1,3,5,8-tetraene"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
汕 -Ionol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Androstenol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"(3R, 6∩Z)-3,4-Dihydro-8-hydroxy-3-(6-pentadecenyl)-1H-2-benzopyran-1-one"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
6-Tridecylsalicylic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
"2,3-dihydroxypropyl dodecanoate"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Methylmalonic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Lysyl-Valine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Prolyl-Methionine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
VPGPR Enterostatin	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
1H-Indol-3-ylacetyl-myo-inositol	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
1-Pentadecene	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Lithocholic acid glycine conjugate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Lactate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 30121347"
Glyceraldehyde	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Pyruvate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318, 26057937"
Valine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Isoleucine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Leucine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937, 31186025"
Alanine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
Glutamine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
Tyrosine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
Phenylalanine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
d-Glutamic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Ferulic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Salicylic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Lysine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
3-Methylhistidine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
汐-Keto-汕-methylvalerate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
汐-Ketoisovalerate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
汐-Ketoisocaproate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Hexanoyl (C6)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Malonyl (C3DC)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Hydroxyisovaleryl (C5OH)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Octenoyl (C8:1)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Adipyl (C6DC)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
汕-Hydroxybutyrate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Succinate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Malate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Oxaloacetate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Cis-aconitate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Acetate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
Acetoacetate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
3-Hyroxybutyrate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 29113318"
N-Methylnicotinamide	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
N1-Methyl-2-pyridone-5-carboxamide (2PY)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
N1-Methyl-4-pyridone-3-carboxamide (4PY)	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 26057937"
Deoxycorticosterone	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
Pregnenolone	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
17-Hydroxyprogesterone	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758935"
3-Hydroxynonanoyl carnitine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
Eicosapentaenoic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
Phytosphingosine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31186025"
N-acetylneuraminic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Pyridoxal 5∩-phosphate	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Purine	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
"1,3-Dimethyluracil"	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Oxalic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Phenylglyoxylic acid	oogenesis	related	disease	Polycystic ovary syndrome (PCOS)?	D011085	F0	Follicular fluid (FF) is an alternative and a useful biological matrix to study the potential mechanism of Polycystic ovary syndrome (PCOS) pathophysiology. The most significant changes in FF metabolites in women with PCOS in comparison with the control subjects.	Homo sapiens	"32659951, 31758934"
Chemical_name	Reproductive process	Interaction	End_point category	End_point	Mesh ID 	Generation	Descriptions	Species	References
Methyl parathion	spermatogenesis	affect	phenotype	altered hormonal balance	N/A	F0	"Studies in men and animals have shown that Me-Pa alone, or in combination with other OP, alters male reproductive function, particularly semen quality, sperm chromatin condensation, and hormonal balance?"	Homo sapiens	11039162
Methyl parathion	spermatogenesis	affect	phenotype	altered semen quality	N/A	F0	"Studies in men and animals have shown that Me-Pa alone, or in combination with other OP, alters male reproductive function, particularly semen quality, sperm chromatin condensation, and hormonal balance?"	Homo sapiens	11039162
Methyl parathion	spermatogenesis	affect	phenotype	altered sperm chromatin condensation	N/A	F0	"Studies in men and animals have shown that Me-Pa alone, or in combination with other OP, alters male reproductive function, particularly semen quality, sperm chromatin condensation, and hormonal balance?"	Homo sapiens	11039162
Myristic acid (C14:0)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Myristic acid (C14:0) is significantly different between Normozoospermia and Asthenozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Palmitic acid (C16:0)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Palmitic acid (C16:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Stearic acid (C18:0)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Stearic acid (C18:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Arachidic acid (C20:0)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Arachidic acid (C20:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Palmitoleic acid (C16:1n-7)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Palmitoleic acid (C16:1n-7) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Gondoic acid (C20:1n-9)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Gondoic acid (C20:1n-9) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Erucic acid (C22:1n-9)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Erucic acid (C22:1n-9) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Docosahexaenoic acid (C22:6)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Docosahexaenoic acid (C22:6) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Docosadienoic acid (C22:2)	spermatogenesis	related	disease	asthenozoospermia	D053627	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Docosadienoic acid (C22:2) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Phosphatidylcholine (PC)	spermatogenesis	relate	disease	Idiopathic infertility	N/A	F0	Phosphatidylcholine (PC) decreased in idiopathic infertility.	Homo sapiens	"34445473, 2010008"
Phosphatidylcholine (PC)	spermatogenesis	relate	disease	"Infertility, Male"	D007248	F0	"PE:PC ratio of seminal plasma: significant differences between patients with spermatogenic failure and obstructive azoospermia. (Phosphatidylcholine (PC),Phosphatidylethanolamine (PE) )"	Homo sapiens	"34445473, 8464025"
Phosphatidylethanolamine (PE)	spermatogenesis	relate	disease	"Infertility, Male"	D007248	F0	"PE:PC ratio of seminal plasma: significant differences between patients with spermatogenic failure and obstructive azoospermia. (Phosphatidylcholine (PC),Phosphatidylethanolamine (PE) )"	Homo sapiens	"34445473, 8464025"
DDT	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	"Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa."	Homo sapiens	17192596
Dichlorodiphenyl Dichloroethylene	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	High DDE-DDT exposure adversely affected all 3 sperm parameters and its effects were exacerbated by the GSTT1 null polymorphism and by the CYP1A1 common alleles.	Homo sapiens	"19303595, 12948891"
Methyl parathion	spermatogenesis	affect	disease	"Infertility, Male"	D007248	F0	"Studies in men and animals have shown that Me-Pa alone, or in combination with other OP, alters male reproductive function, particularly semen quality, sperm chromatin condensation, and hormonal balance?"	Homo sapiens	11039162
Omega-3 fatty acids	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Compared the composition of sperm FAs in fertile and infertile men and found higher omega-3 FAs in the fertile group but higher levels and percentages of arachidonic acid in the infertile group.	Homo sapiens	"34445473, 19666200"
arachidonic acid	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Compared the composition of sperm FAs in fertile and infertile men and found higher omega-3 FAs in the fertile group but higher levels and percentages of arachidonic acid in the infertile group.	Homo sapiens	"34445473, 19666200"
organophosphorus pesticides (OPs) 	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Acephate is a highly toxic extensively used organophosphorus pesticides (OPs) and exposure to acephate may result in alterations of sperm structure and function thus contributing towards deteriorating in human semen quality triggering infertility.	Homo sapiens	28392800
Palmitic acid (C16:0)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Palmitic acid (C16:0) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"11339641, 16961570, 17855064, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Stearic acid (C18:0)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Stearic acid (C18:0) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"11339641, 16893631, 16961570, 17855064, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Oleic acid (C18:1)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Oleic acid (C18:1) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"9542967, 10529089, 16893631, 17855064, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
汐-Linolenic acid (C18:3)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. 汐-Linolenic acid (C18:3) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"19666200, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Eicosapentaenoic acid (C20:5)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Eicosapentaenoic acid (C20:5) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"19666200, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Docosahexaenoic acid (C22:6)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Docosahexaenoic acid (C22:6) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"9542967, 10529089,11339641, 16893631, 16961570,19666200, 11339641, 17855064, 23596043, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Linoleic acid (C18:2)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Linoleic acid (C18:2) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"16961570, 17855064, 19666200, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Arachidonic acid (C20:4)	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Sperm fatty acid levels in controls compared to abnormal seminal conditions. Arachidonic acid (C20:4) is significant different between the controls and infertile group. Control definition and units of measure are reported as indicated in the related reference sources.	Homo sapiens	"17855064, 19666200, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Phosphatidylcholine (PC)	spermatogenesis	relate	disease	Obstructive azoospermia	C536718	F0	Phosphatidylcholine (PC) content of seminal plasma decreased in obstructive azoospermia patients and vasectomy patients. And PE:PC ratio of seminal plasma: significant differences between patients with spermatogenic failure and obstructive azoospermia.	Homo sapiens	"34445473, 8464025, 11250795"
Phosphatidylethanolamine (PE)	spermatogenesis	relate	disease	Obstructive azoospermia	C536718	F0	"PE:PC ratio of seminal plasma: significant differences between patients with spermatogenic failure and obstructive azoospermia. (Phosphatidylcholine (PC),Phosphatidylethanolamine (PE) )"	Homo sapiens	"34445473, 8464025"
Myristic acid (C14:0)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Myristic acid (C14:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Palmitic acid (C16:0)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Palmitic acid (C16:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Stearic acid (C18:0)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Stearic acid (C18:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Arachidic acid (C20:0)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Arachidic acid (C20:0) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Palmitoleic acid (C16:1n-7)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Palmitoleic acid (C16:1n-7) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Gondoic acid (C20:1n-9)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Gondoic acid (C20:1n-9) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Erucic acid (C22:1n-9)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Erucic acid (C22:1n-9) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Docosahexaenoic acid (C22:6)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Docosahexaenoic acid (C22:6) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Docosadienoic acid (C22:2)	spermatogenesis	related	disease	oligoasthenoteratozoospermia	D009845	F0	Seminal fatty acid levels in normozoospermia compared to abnormal seminal conditions. Docosadienoic acid (C22:2) is significantly different between Normozoospermia and oligoasthenoteratozoospermia.	Homo sapiens	"27673576, Collodel, G et al., Oxidative medicine and cellular longevity, 2020."
Benzene	spermatogenesis	related	phenotype	fetal development	N/A	F0	"Men exposed to high levels of benzene are more likely to have an abnormal amount of chromosome in their sperm, which impacts fetal development."	Homo sapiens	24416599
Benzene	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	"Men exposed to high levels of benzene are more likely to have an abnormal amount of chromosome in their sperm, which impacts fertility."	Homo sapiens	24416599
organophosphorus pesticides (OPs) 	spermatogenesis	related	disease	"Infertility, Male"	D007248	F0	Acephate is a highly toxic extensively used organophosphorus pesticides (OPs) and exposure to acephate may result in alterations of sperm structure and function thus contributing towards deteriorating in human semen quality triggering infertility.	Homo sapiens	28392800
Vitamin A	embryo development	affect	disease	"Abnormalities, Multiple"	D000015	F1	"High (100 mg/kg) and moderate (50 and 25 mg/kg) doses of vitamin A resulted in significant craniofacial, cardiac outflow tract and thymic abnormalities."	Mus musculus	10992263
Ethanol	embryo development	affect	disease	"Abnormalities, Severe Teratoid"	D009008	F1	Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice.	Mus musculus	23733920
Hydroxyurea	embryo development	affect	disease	"Abnormalities, Severe Teratoid"	D009008	F1	Deprenyl enhances the teratogenicity of hydroxyurea in organogenesis stage mouse embryos.	Mus musculus	23696560
Methadone	embryo development	affect	disease	Anencephaly	D000757	F1	Teratogenic activity of methadone hydrochloride in mouse and chick embryos.	Mus musculus	4586767
Trihalomethanes	embryo development	affect	disease	Anencephaly	D000757	F1	Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.	Mus musculus	21505091
Oligodeoxyribonucleotides	embryo development	affect	disease	Anophthalmos	D000853	F1	Maternal treatment with a high dose of CpG ODN(oligodeoxynucleotides (ODN) containing CpG motifs) during gestation alters fetal craniofacial and distal limb development in C57BL/6 mice.	Mus musculus	16143434
Doxorubicin	embryo development	affect	disease	Anorectal Malformations	D000071056	F1	"Adriamycin produces a reproducible teratogenic model of vertebral, anal, cardiovascular, tracheal, esophageal, renal, and limb anomalies in the mouse."	Mus musculus	17923191
Glyphosate	embryo development	related	phenotype	behavioral impairments	N/A	F1	"Effects of glyphosate-based herbicides (GBH) on offspring lasting into adulthood.?In offspring, GBH was responsible for a global delay in innate reflexes and a deficit in motor development. At the adult age, exposed animals showed a decrease of locomotor activity, sociability, learning and short- and long-term memory associated with alterations of cholinergic and dopaminergic systems. Furthermore, GBH-activated microglia and astrocytes, sign of neuroinflammation event in the medial prefrontal cortex and hippocampus."	Mus musculus	32067069
Glyphosate	embryo development	related	phenotype	Congenital Abnormalities	D000013	F1	"Effects of glyphosate-based herbicides (GBH) on offspring lasting into adulthood. In offspring, GBH was responsible for a global delay in innate reflexes and a deficit in motor development. At the adult age, exposed animals showed a decrease of locomotor activity, sociability, learning and short- and long-term memory associated with alterations of cholinergic and dopaminergic systems. Furthermore, GBH-activated microglia and astrocytes, sign of neuroinflammation event in the medial prefrontal cortex and hippocampus."	Mus musculus	32067069
Glucose	embryo development	affect	disease	Congenital Abnormalities	D000013	F1	Maternal blood glucose levels determine the severity of diabetic embryopathy in mice with different expression of copper-zinc superoxide dismutase (CuZnSOD).	Mus musculus	18502742
Methanol	embryo development	affect	disease	Craniofacial Abnormalities	D000013	F1	Methanol administered to C57BL/6J mice during gastrulation causes severe craniofacial dysmorphology	Mus musculus	15108243
Carbamazepine	embryo development	affect	disease	Craniofacial Abnormalities	D000013	F1	Carbamazepine [CMZ] was teratogenic and embryotoxic at all dose levels. 	Mus musculus	6438150
Sodium valproate	embryo development	affect	disease	Craniofacial Abnormalities	D000013	F1	Sodium valproate [NaV] was teratogenic and embryotoxic at all dose levels.	Mus musculus	6438150
Diphenylhydantoin	embryo development	affect	disease	Craniofacial Abnormalities	D000013	F1	Diphenylhydantoin [DPH]) was teratogenic and embryotoxic at all dose levels.	Mus musculus	6438150
Atrazine	embryo development	affect	disease	Cryptorchidism	D003456	F1	Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring.	Mus musculus	33463082
Atrazine	embryo development	affect	disease	Cryptorchidism	D003456	F1	Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring.	Mus musculus	33463082
di(2-ethylhexyl) phthalate	embryo development	affect	phenotype	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
di-isobutyl phthalate	embryo development	affect	phenotype	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
Phthalate mixture	embryo development	affect	disease	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
dibutyl phthalate	embryo development	affect	disease	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
di-isononyl phthalate	embryo development	affect	phenotype	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
benzylbutyl phthalate	embryo development	affect	phenotype	Ovarian Cysts	D010048	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure induced cystic ovaries in the F2 generation."	Mus musculus	28368545
Phthalate mixture	embryo development	decrease	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
diethyl phthalate	embryo development	decrease	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
di(3-ethylhexyl) phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
dibutyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F4 generation."	Mus musculus	28368545
di-isononyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
benzylbutyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
di-isobutyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
Chlordecone	embryo development	related	disease	Delayed puberty	N/A	F2	"Gestational exposure to low dose of CD leads to oxidative stress and affects meiosis and gene expression in embryonic ovaries. In the adult animals from the same lineage, we observed delayed puberty and decreased number of primordial (but increased the number of atretic) follicles.?"	Mus musculus	31084621
Di(2-Ethylhexyl) Phthalate	embryo development	affect	disease	Disorders of Sex Development	D012734	F1	Di(2-Ethylhexyl) phthalate exposure in utero damages sertoli cell differentiation via disturbance of sex determination pathway in fetal and postnatal mice	Mus musculus	27060630
Di(2-Ethylhexyl) Phthalate	embryo development	affect	disease	Disorders of Sex Development	D012734	F1	DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice.	Mus musculus	"27495896, 26219507 "
Progesterone	embryo development	affect	disease	Disorders of Sex Development	D012734	F1	Progesterone inhibits uterine gland development in the neonatal mouse uterus.	Mus musculus	22238285
di(2-ethylhexyl) phthalate	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
dibutyl phthalate	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
di-isobutyl phthalate	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
Phthalate mixture	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
diethyl phthalate	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
di-isononyl phthalate	embryo development	affect	disease	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
benzylbutyl phthalate	embryo development	affect	phenotype	fertility complications	N/A	"F2, F3"	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure caused fertility complications in the F2 and F3 generation. "	Mus musculus	28368545
Valproic Acid	embryo development	affect	disease	Hypoplastic Left Heart Syndrome	D018636	F1	Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.	Mus musculus	"8211818, 2284927"
Atrazine	embryo development	affect	disease	Hypospadias	D007021	F1	Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring.	Mus musculus	33463082
Diethylstilbestrol	embryo development	affect	disease	Hypospadias	D007021	F1	Diethylstilbestrol-induced hypospadias formation is dependent on age at time of exposure.	Mus musculus	11748570
Phthalate mixture	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
diethyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di(2-ethylhexyl) phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
dibutyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isononyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isobutyl phthalate	embryo development	affect	phenotype	Anogenital distance	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
Phthalate mixture	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
diethyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di(2-ethylhexyl) phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
dibutyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isononyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
benzylbutyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
benzylbutyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isobutyl phthalate	embryo development	affect	phenotype	Body weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
Phthalate mixture	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
Phthalate mixture	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
diethyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
diethyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
di(2-ethylhexyl) phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di(2-ethylhexyl) phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
dibutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
dibutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
di-isononyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isononyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
benzylbutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
benzylbutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
di-isobutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F2	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, anogenital distance, and body weight in the F2 generation."	Mus musculus	28368545
di-isobutyl phthalate	embryo development	increase	phenotype	Uterine weight	N/A	F3	"Prenatal phthalate mixture  (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) exposure increased uterine weight, decreased anogenital distance in the F3 generation. "	Mus musculus	28368545
Di(2-Ethylhexyl) Phthalate	embryo development	related	phenotype	"Infertility, Female"	D007247	F2	Di(2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice. 	Mus musculus	"30998239, 29471507, 29228129 "
Phthalate mixture	embryo development	affect	disease	"Infertility, Female"	D007247	"F2, F3"	"Prenatal exposure to the phthalate mixture (a phthalate mixture made of 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% di-isononyl phthalate, 8% di-isobutyl phthalate, and 5% benzylbutyl phthalate ) induces multigenerational and transgenerational effects on female reproduction."	Mus musculus	"30998239, 28368545, 28126412 "
Glyphosate	embryo development	related	disease	"Infertility, Female"	D007247	F1	Pre- and neonatal exposure to glyphosate-based herbicides (GBH) impairs fertility and reproduction parameters as well as maternal behavior of exposed mothers	Mus musculus	32067069
bisphenol A	embryo development	affect	disease	"Infertility, Female"	D007247	F1	Prenatal exposure to bisphenol A analogs have transgenerational effects on female reproductive functions in mice.	Mus musculus	31132128
bisphenol S	embryo development	affect	disease	"Infertility, Female"	D007247	F1	"Prenatal exposure to bisphenol A analogs,  bisphenol S and bisphenol E, have transgenerational effects on female reproductive functions in mice."	Mus musculus	31132128
bisphenol E	embryo development	affect	disease	"Infertility, Female"	D007247	F1	"Prenatal exposure to bisphenol A analogs,  bisphenol S and bisphenol E, have transgenerational effects on female reproductive functions in mice."	Mus musculus	31132128
"2,3',4,4'5-pentachlorobiphenyl (PCB118)"	embryo development	affect	disease	"Infertility, Male"	D007252	F1	Exposure of pregnant mice to PCB118 during primordial germ cell migration in the fetus affects the reproductive system of the offspring and decreases global methylation levels in the testis.	Mus musculus	"32758352, 32418265"
bisphenol A	embryo development	affect	disease	"Infertility, Male"	D007253	F1	"Prenatal exposure to bisphenol A, bisphenol S and bisphenol E induces transgenerational effects on male reproductive functions probably due to altered epigenetic modification following disruption of DNMTs and histone marks in the neonatal and/or adult testis."	Mus musculus	"31532523, 27417731"
bisphenol S	embryo development	affect	disease	"Infertility, Male"	D007254	F1	"Prenatal exposure to bisphenol A, bisphenol S and bisphenol E induces transgenerational effects on male reproductive functions probably due to altered epigenetic modification following disruption of DNMTs and histone marks in the neonatal and/or adult testis."	Mus musculus	31532523
bisphenol E	embryo development	affect	disease	"Infertility, Male"	D007255	F1	Prenatal exposure to bisphenol E induces transgenerational effects on male reproductive functions probably due to altered epigenetic modification following disruption of DNMTs and histone marks in the neonatal and/or adult testis.	Mus musculus	31532523
Zearalenone (ZEA)	embryo development	affect	disease	"Infertility, Male"	D007256	F1	Gestational exposure to low-dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications. The histone methylation markers H3K9 and H3K28 were elevated	Mus musculus	31058416
Vinclozolin	embryo development	increase	phenotype	Kidney abnormalities	N/A	F3	"To investigate the transgenerational actions of vinclozolin on the mouse, transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities and polycystic ovarian disease. "	Mus musculus	"30998239, 23041264"
Ethanol	embryo development	affect	disease	"Limb Deformities, Congenital"	D017880	F1	"Ethanol, Disulfiram, and BMS-189453 resulted in postaxial ectrodactyly, intermediate ectrodactyly, and other digital defects."	Mus musculus	"17676605, 1412063, 2160130"
Disulfiram	embryo development	affect	disease	"Limb Deformities, Congenital"	D017880	F1	"Ethanol, Disulfiram, and BMS-189454 resulted in postaxial ectrodactyly, intermediate ectrodactyly, and other digital defects."	Mus musculus	17676605
BMS-189453	embryo development	affect	disease	"Limb Deformities, Congenital"	D017880	F1	"Ethanol, Disulfiram, and BMS-189455 resulted in postaxial ectrodactyly, intermediate ectrodactyly, and other digital defects."	Mus musculus	17676605
Chlordecone	embryo development	related	disease	Hepatitis	D006505	F2	"Exposure to CD during the crucial developmental window (embyonic days E6.5-E15.5) induces an increase in PIN phenotype, leads to changes in gene expression in liver and affects the H3K4me3 histone occupancy at developmental genes in both F1 and F3 generations. Gestational exposure to CD leads to an up-regulation of genes involved in DNA repair, detoxification and inflammation in the liver."	Mus musculus	29980752
Ethanol	embryo development	affect	disease	Nervous System Malformations	D009421	F1	"long-term alterations to cortical anatomy, including atypical developmental cortical thinning, and abnormal subcortical development as a result of in utero EtOH exposure. Offspring exposed to EtOH during the prenatal period performed poorly on behavioral tasks measuring sensorimotor integration and anxiety."	Mus musculus	26727530
Benzo(a)pyrene	embryo development	affect	disease	Neural Tube Defects	D009436	F1	Distinct H3K27me3 and H3K27ac Modifications in Neural Tube Defects Induced by Benzo[a]pyrene. Benzo[a]pyrene (BaP) (one of the common PAHs with high toxicity) induced-NTD mouse model.	Mus musculus	36831877
Cyproterone Acetate	embryo development	affect	disease	Neural Tube Defects	D009436	F1	Teratogenic effects of cyproterone acetate and medroxyprogesterone treatment during the pre- and postimplantation period of mouse embryos.	Mus musculus	"6461082, 6214037"
Methanol	embryo development	affect	disease	Neural Tube Defects	D009436	F1	Methanol-induced neural tube defects in mice: pathogenesis during neurulation	Mus musculus	7747271
Chlordecone	embryo development	related	disease	Oligospermia	D009845	F2	"Exposed pregnant mice to CD from embryonic day 6.5 to 15.5 and observed a reduction in spermatogonia (SG) numbers in F3, meiotic defects in spermatocytes and decrease in spermatozoa number in the first and third generation of male progeny.?"	Mus musculus	29980752
Chlordecone	embryo development	related	disease	Ovarian dysfunction	N/A	F2	"Gestational exposure to low dose of CD leads to oxidative stress and affects meiosis and gene expression in embryonic ovaries. In the adult animals from the same lineage, we observed delayed puberty and decreased number of primordial (but increased the number of atretic) follicles.?"	Mus musculus	31084621
Vinclozolin	embryo development	increase	phenotype	Permatogenic cell defects	N/A	F3	"To investigate the transgenerational actions of vinclozolin on the mouse, transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities and polycystic ovarian disease. "	Mus musculus	"30998239, 23041264"
Vinclozolin	embryo development	increase	phenotype	Polycystic ovary syndrome (PCOS)?	D011085	F3	"To investigate the transgenerational actions of vinclozolin on the mouse, transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities and polycystic ovarian disease. "	Mus musculus	"30998239, 23041264"
Vinclozolin	embryo development	increase	phenotype	Prostate abnormalities	N/A	F3	"To investigate the transgenerational actions of vinclozolin on the mouse, transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities and polycystic ovarian disease. "	Mus musculus	"30998239, 23041264"
Chlordecone	embryo development	increase	disease	Prostatic intraepithelial neoplasia	D019048	"F1, F3"	Exposed pregnant Swiss mice to Chlordecone caused an increased prostatic intraepithelial neoplasia phenotype (PIN) in both F1 and F3 generations. 	Mus musculus	33711761
Methadone	embryo development	affect	disease	Spinal Dysraphism	D016135	F1	Teratogenic activity of methadone hydrochloride in mouse embryos.	Mus musculus	4586767
Vinclozolin	embryo development	increase	phenotype	Testicular abnormalities	N/A	F3	"Transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities."	Mus musculus	"30998239, 23041264"
vinclozolin	embryo development	affect	disease	Urogenital Abnormalities	D014564	F1	"Vinclozolin-induced mouse penile malformation and ""small testis"" via miR132, miR195a together with the Hippo signaling pathway."	Mus musculus	34182078
Serotonin?	embryo development	affect	disease	Craniofacial malformations	C536735	F1	Exposure of mouse embryos in whole embryo culture to sertraline caused craniofacial malformations.	Mus musculus	"1412065, 1412065"
Fluoxetine	embryo development	affect	disease	Craniofacial malformations	C536735	F1	Exposure of mouse embryos in whole embryo culture to fluoxetine caused craniofacial malformations.	Mus musculus	"1412065, 1412065"
Amitriptyline	embryo development	affect	disease	Craniofacial malformations	C536735	F1	Exposure of mouse embryos in whole embryo culture to amitriptyline caused craniofacial malformations.	Mus musculus	"1412065, 1412065"
Methoxychlor	female gamete generation	related	phenotype	"Infertility, Female"	D007247	F0	Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro.	Mus musculus	21514315
"2,3',4,4'5-pentachlorobiphenyl (PCB118)"	female gamete generation	affect	disease	"Infertility, Female"	D007247	F1	"Prenatal exposure to PCB118 altered the DNA methylation status of differentially methylated regions in some imprinted genes, and the expression levels of Dnmt1, 3a, and 3l, Uhrf1 and Tet3 were also changed. In addition, PCB119 disturbed the maturation process of progeny mouse oocytes in a dose-dependent manner."	Mus musculus	31388691
bisphenol A	male gamete generation	increase	phenotype	Inflammatory response	N/A	F1	Decreased capacity for sperm production induced by perinatal bisphenol A exposure is associated with an increased inflammatory response in the offspring of C57BL/6 Male Mice.	Mus musculus	30275377
vitexin	male gamete generation	affect	disease	"Infertility, Male"	D007249	F0	Vitexin significantly improved the sexual behavior and fertility levels compared with the diabetic group.	Mus musculus	30365938
Lycium barbarum polysaccharide	male gamete generation		disease	"Infertility, Male"	D007250	F0	Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice	Mus musculus	28225103
Methyl Parathion	male gamete generation	affect	disease	"Infertility, Male"	D007251	F0	Methyl-parathion exposure of maturing spermatozoa and spermatocytes affects many sperm functional parameters that result in a decreased fertilizing capacity. Oxidative stress seems to be a likely mechanism of the detrimental effects of Me-Pa exposure in male germ cells.	Mus musculus	19442678
bisphenol A	male gamete generation	related	phenotype	Oligospermia	D009845	F0	Decreased capacity for sperm production induced by perinatal bisphenol A exposure is associated with an increased inflammatory response in the offspring of C57BL/6 Male Mice.	Mus musculus	30275377
vitexin	male gamete generation	increase	phenotype	Reproductive organ weight	N/A	F0	Vitexin significantly increased reproductive organ weight.	Mus musculus	30365938
bisphenol A	male gamete generation	related	disease	Teratozoospermia	D000072660	F0	"Bisphenol A significantly reduced sperm counts, impaired sperm motility, and increased the percentage of malformed spermatozoa. "	Mus musculus	31489793
Vitexin	male gamete generation	increase	phenotype	testicular pathological structure damage	N/A	F0	Vitexin improved testicular pathological structure damage.	Mus musculus	30365938